NEFM

NEFM
Ідентифікатори
Символи NEFM, NEF3, NF-M, NFM, neurofilament, medium polypeptide, neurofilament medium, neurofilament medium chain
Зовнішні ІД OMIM: 162250 MGI: 97314 HomoloGene: 38041 GeneCards: NEFM
Шаблон експресії
Більше даних
Ортологи
Види Людина Миша
Entrez
4741
18040
Ensembl
ENSG00000104722
ENSMUSG00000022054
UniProt
P07197
P08553
RefSeq (мРНК)
NM_005382
NM_001105541
NM_008691
RefSeq (білок)
NP_001099011
NP_005373
NP_032717
Локус (UCSC) Хр. 8: 24.91 – 24.92 Mb Хр. 14: 68.32 – 68.36 Mb
PubMed search [1] [2]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

NEFM (англ. Neurofilament medium) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 916 амінокислот, а молекулярна маса — 102 472[4].

Послідовність амінокислот
1020304050
MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSS
SYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSN
EKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAY
DQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTE
AAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQ
ASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT
EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEE
RHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAA
YRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQH
KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE
AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE
GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE
LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE
KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE
QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTIT
KSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDI
AVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEE
KVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV
EKVTSHAIVKEVTQSD

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як ацетилювання, альтернативний сплайсинг.

Література

  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Myers M.W., Lazzarini R.A., Lee V.M.-Y., Schlaepfer W.W., Nelson D.L. (1987). The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family. EMBO J. 6: 1617—1626. PMID 3608989

Примітки

  1. ↑ Human PubMed Reference:.
  2. ↑ Mouse PubMed Reference:.
  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:7734 (англ.) . Архів оригіналу за 27 липня 2016. Процитовано 7 вересня 2017. [Архівовано 2016-07-27 у Wayback Machine.]
  4. ↑ UniProt, P07197 (англ.) . Архів оригіналу за 3 жовтня 2017. Процитовано 7 вересня 2017.

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