TUBA1C

TUBA1C
Ідентифікатори
Символи TUBA1C, TUBA6, bcm948, tubulin alpha 1c
Зовнішні ІД MGI: 1095409 HomoloGene: 69045 GeneCards: TUBA1C
Реагує на сполуку
velban, ixabepilone, plinabulin, vinblastine sulfate, patupilone, vincristine sulfate, dolastatin 10[1]
Шаблон експресії


Більше даних
Ортологи
Види Людина Миша
Entrez
84790
22146
Ensembl
ENSG00000167553
ENSMUSG00000043091
UniProt
Q9BQE3
P68373
RefSeq (мРНК)
NM_032704
NM_001303114
NM_001303115
NM_001303116
NM_001303117
NM_009448
RefSeq (білок)
NP_001290043
NP_001290044
NP_001290045
NP_001290046
NP_116093
NP_033474
Локус (UCSC) Хр. 12: 49.19 – 49.27 Mb Хр. 15: 98.93 – 98.94 Mb
PubMed search [2] [3]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

TUBA1C (англ. Tubulin alpha 1c) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 449 амінокислот, а молекулярна маса — 49 895[5].

Послідовність амінокислот
1020304050
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFN
TFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAA
NNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFT
SLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC
AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNV
DLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG
FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYA
KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSADGEDEGEEY

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у такому біологічному процесі, як ацетилювання. Білок має сайт для зв'язування з нуклеотидами, ГТФ. Локалізований у цитоплазмі, цитоскелеті.

Література

  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Valenstein M.L., Roll-Mecak A. (2016). Graded control of microtubule severing by tubulin glutamylation. Cell. 164: 911—921. PMID 26875866 DOI:10.1016/j.cell.2016.01.019
  • Nirschl J.J., Magiera M.M., Lazarus J.E., Janke C., Holzbaur E.L. (2016). Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons. Cell Rep. 14: 2637—2652. PMID 26972003 DOI:10.1016/j.celrep.2016.02.046

Примітки

  1. ↑ Сполуки, які фізично взаємодіють з Tubulin alpha 1c переглянути/редагувати посилання на ВікіДаних.
  2. ↑ Human PubMed Reference:.
  3. ↑ Mouse PubMed Reference:.
  4. ↑ HUGO Gene Nomenclature Commitee, HGNC:20768 (англ.) . Архів оригіналу за 20 вересня 2017. Процитовано 11 вересня 2017. [Архівовано 2017-09-20 у Wayback Machine.]
  5. ↑ UniProt, Q9BQE3 (англ.) . Архів оригіналу за 16 вересня 2017. Процитовано 11 вересня 2017.

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