KRT72

KRT72
Ідентифікатори
Символи KRT72, K6IRS2, K6irs, KRT6, KRT6IRS2, keratin 72, K72, CK-72
Зовнішні ІД OMIM: 608246 MGI: 2146034 HomoloGene: 25876 GeneCards: KRT72
Ортологи
Види Людина Миша
Entrez
140807
105866
Ensembl
ENSG00000170486
ENSMUSG00000056605
UniProt
Q14CN4
Q6IME9
RefSeq (мРНК)
NM_001146225
NM_001146226
NM_080747
NM_213728
RefSeq (білок)
NP_001139697
NP_001139698
NP_542785
NP_998893
Локус (UCSC) Хр. 12: 52.59 – 52.6 Mb Хр. 15: 101.68 – 101.69 Mb
PubMed search [1] [2]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

KRT72 (англ. Keratin 72) – білок, який кодується однойменним геном, розташованим у людей на 12-й хромосомі.[3] Довжина поліпептидного ланцюга білка становить 511 амінокислот, а молекулярна маса — 55 877[4].

Послідовність амінокислот
1020304050
MSRQLTHFPRGERLGFSGCSAVLSGGIGSSSASFRARVKGSASFGSKSLS
CLGGSRSLALSAAARRGGGRLGGFVGTAFGSAGLGPKCPSVCPPGGIPQV
TVNKSLLAPLNVEMDPEIQRVRAQEREQIKALNNKFASFIDKVRFLEQQN
QVLETKWNLLQQLDLNNCRKNLEPIYEGYISNLQKQLEMLSGDGVRLDSE
LRNMQDLVEDYKKRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKV
DSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDNNRDLDLDSIIAEVR
AQYEEIALKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEISELNRLI
QRIRSEIGNVKKQCADLETAIADAEQRGDCALKDARAKLDELEGALHQAK
EELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISV
ISSTNAGAGGAGFSMGFGASSSYSYKTAAADVKTKGSCGSELKDPLAKTS
GSSCATKKASR

Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Локалізований у проміжних філаментах.

Література

  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004.  PMID 15489334 DOI:10.1101/gr.2596504
  • Langbein L., Rogers M.A., Praetzel S., Winter H., Schweizer J. (2003). K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J. Invest. Dermatol. 120: 512—522.  PMID 12648212 DOI:10.1046/j.1523-1747.2003.12087.x

Примітки

  1. ↑ Human PubMed Reference:. 
  2. ↑ Mouse PubMed Reference:. 
  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:28932 (англ.) . Архів оригіналу за 10 вересня 2015. Процитовано 19 вересня 2017.  [Архівовано 2015-09-10 у Wayback Machine.]
  4. ↑ UniProt, Q14CN4 (англ.) . Архів оригіналу за 6 травня 2017. Процитовано 19 вересня 2017. 

Див. також

Молекула міоглобіну Це незавершена стаття про білки.
Ви можете допомогти проєкту, виправивши або дописавши її.

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