Хромосома 8 (людина)

Ідіограма 8-ї хромосоми людини

Хромосома 8 — одна з 23 пар хромосом людини. За нормальних умов у людей дві копії цієї хромосоми. 8-та хромосома має в своєму складі 145 млн пар основ або 4-5 % від загальної кількості нуклеотидів в ДНК клітин[1][2].
Ідентифікація генів кожної хромосоми є пріоритетним напрямком наукових досліджень в генетиці. Проте, дослідники застосовують різні підходи щодо визначення кількості генів в кожній хромосомі, внаслідок цього дані щодо їх кількості демонструють різні цифри. Це також стосується і хромосоми 8, в якій налічюють від 700 до 1000 генів[3].

Гени

Найвивченішими генами, що розташовані в хромосомі 8 є наступні:

Плече p

Плече q

Хвороби та розлади

Посилання

  1. ↑ Nusbaum C та ін. (2006). DNA sequence and analysis of human chromosome 8. Nature. 439 (7074): 331—5. doi:10.1038/nature04406. PMID 16421571. {{cite journal}}: Явне використання «та ін.» у: |author= (довідка)
  2. ↑ Tabarés-Seisdedos R, Rubenstein JL (2009). Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer. Mol Psychiatry. 14 (6): 563—89. doi:10.1038/mp.2009.2. PMID 19204725.
  3. ↑ Gilbert F (2001). Chromosome 8. Genet Test. 5 (4): 345—54. doi:10.1089/109065701753617516. PMID 11960583.


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