Testosterone buciclate (developmental code names 20 Aet-1, CDB-1781) is a synthetic, injected anabolic–androgenic steroid (AAS) which was never marketed.[3][4][5] It was developed in collaboration by the Contraceptive Development Branch (CDB) of the National Institute of Child Health and Human Development (NICHD) and the World Health Organization (WHO) in the 1970s and early 1980s for use in androgen replacement therapy for male hypogonadism and as a potential male contraceptive.[3] It was first described in 1986.[4] The medication is an androgen ester – specifically, the C17β buciclate (4-butylcyclohexane-1-carboxylate) ester of testosterone – and is a prodrug of testosterone with a very long duration of action when used as a depot via intramuscular injection.[3][6] Testosterone buciclate is formulated as a microcrystalline aqueous suspension with a defined particle size of at least 75% in the range of 10 to 50 μm.[7]
A single intramuscular injection of testosterone buciclate has been found to produce physiological levels of testosterone within the normal range in hypogonadal men for 3 to 4 months.[3][1][8][9][2] The elimination half-life and mean residence time (average amount of time a single molecule of drug stays in the body) of testosterone buciclate were found to be 29.5 days and 60.0 days, respectively, whereas those of testosterone enanthate in castor oil were only 4.5 days and 8.5 days.[8][9][2] Testosterone buciclate also lasts longer than testosterone undecanoate, which has elimination half-lives and mean residence times of 20.9 days and 34.9 days in tea seed oil and 33.9 days and 36.0 days in castor oil, respectively.[1][9][2] In addition, there is a spike in testosterone levels with testosterone enanthate and testosterone undecanoate that is not seen with testosterone buciclate, with which levels stay highly uniform and decrease very gradually and progressively.[1] Testosterone buciclate can maintain testosterone levels in the normal male range for up to 20 weeks with a single intramuscular injection.[10]
Testosterone buciclate is able to reversibly and completely suppress spermatogenesis in men when used at sufficiently high dosages.[8] As such, the results of clinical studies for use of testosterone buciclate as a male contraceptive were promising, and trials continued as late as 1995,[11] but progress ultimately came to a standstill because the WHO was unable to find an industry partner willing to continue the development of the drug.[1] Because of this, the WHO backed away from testosterone buciclate and focused its research instead on testosterone undecanoate, which is also very long-lasting and has the advantage of having already been marketed and approved for medical use.[12]
Testosterone buciclate is applied intramuscularly as a microcrystalline aqueous suspension. [...] After air milling [...] of crystalline testosterone buciclate to a particle size of at least 75% in the range of 10 - 50 μm, the drug was [...] suspended in sterile, aqueous suspension vehicle [...].
Corregimiento in Veraguas, PanamaEl PradoCorregimientoCountry PanamaProvinceVeraguasDistrictLas PalmasArea[1] • Land41.2 km2 (15.9 sq mi)Population (2010)[1] • Total1,074 • Density26.1/km2 (68/sq mi) Population density calculated based on land area.Time zoneUTC−5 (EST) El Prado is a corregimiento in Las Palmas District, Veraguas Province, Panama with a population of 1,074 as of 2010.[1] Its populatio…
Bournemouth typhoid outbreakDateAugust 1936 (August 1936)–September 1936 (September 1936)LocationBournemouth, HampshireCauseTyphoid feverOutcome718 casesDeathsAppx. 70 The Bournemouth typhoid outbreak was an outbreak of typhoid in 1936 in the south coast of England, a traditional holiday location. It occurred during the months of August and September. The first cases were traced to raw milk from a dairy supplied by a farm whose cows drank water from a river contaminated by sewage fro…
Károly Doncsecz Károly Doncsecz Sloveens: Karel Dončec (Orfalu (Hongarije), ca. 30 mei 1918 – Körmend (Hongarije), 12 november 2002) was een Sloveens pottenbakker, Meester der Volkskunst, in Hongarije. Doncsecz werd geboren in Comitat Vas. Zijn moeder was Anna Talabér (1900-1920), zijn vader Károly Dancsecz (1894-1927). Het pottenbakken had hij geleerd in Magyarszombatfa. Tot 1940 woonde hij in Kétvölgy. Referentie Some more famous characters - Károly Doncsecz
У Вікіпедії є статті про інші географічні об’єкти з назвою Бейв'ю. Місто Бейв'юангл. Bayview Координати 26°07′45″ пн. ш. 97°24′03″ зх. д. / 26.12940000002777907° пн. ш. 97.401100000027781789° зх. д. / 26.12940000002777907; -97.401100000027781789Координати: 26°07′45″ пн. ш. 97°24′03″ зх. …
Maria Est Coordenadas: 22° 1' S 136° 11' O Geografia física País Polinésia Francesa Arquipélago Tuamotu Gambier Área 7 km² Maria Est é uma das ilhas do arquipélago de Tuamotu-Gambier, pertencente ao Taiti.[1] Referências ↑ «Moerenhout, Jacques-Antoine. Voyages aux iles du grand Ocean». Consultado em 16 de fevereiro de 2014. Arquivado do original em 20 de maio de 2007 Este artigo sobre Geografia da Polinésia Francesa é um esboço. Você pode ajudar a Wikipédi…
Ródão Estação Ferroviária de Ródãoobras junto à estação de Ródão, em 2009 Identificação: 52647 ROD (Ródão)[1] Denominação: Estação Satélite de Ródão Administração: Infraestruturas de Portugal (até 2020: centro;[2] após 2020: sul)[3] Classificação: ES (estação satélite)[1] Tipologia: C [3] Linha(s): L.ª da B. Baixa (PK 63+548) Altitude: 129 m (a.n.m) Coordenadas: 39°39′18.34″N × 7°40′22.07″W (=+39.65509;−7.6728) Localização n…
Hibernian WomenDatos generalesNombre Hibernian Women's Football ClubFundación 1997; 24 años como Preston AthleticRefundación 1999 como Hibernian Girls & Ladies Football ClubEntrenador Dean Gibson[1]InstalacionesEstadio Ainslie ParkCapacidad 3.534 espectadoresUbicación Edimburgo, EscociaInauguración 2008 Titular Última temporadaLiga Scottish Women's Premier League(2019) SubcampeónTítulos 3 (por última vez en 2006-07) Actualidad Scottish Women's Premier League 2…
تناقض الاستدلال التراكمي: إذا تم تقليل الكومة بمقدار حبة واحدة في كل مرة ، في أي نقطة بالضبط لا يمكن اعتبارها كومة؟جزء من سلسلة مقالات حولالمغالطات المنطقية عام المنطق الفلسفي الرياضي الاستدلال الحجة المفارقة المغالطة التفكير النقدي مغالطات صوريَّة في حساب القضايا تأكيد ا…
Segelas jus ceri Jus ceri adalah sebuah jus buah yang terdiri dari sari buah ceri. Hidangan tersebut dikonsumsi sebagai minuman dan dipakai sebagai bahan dalam berbagai makanan, mengolah makanan dan minuman. Hidangan tersebut juga dikonsumsi sebagai suplemen kesehatan. Hidangan tersebut dibuat dengan ceri yang dipres hangat atau dingin, dikumpulkan sari buahnya, dan kemudian disaring dan dipasteurisasi. Bacaan tambahan Howatson, G. (Et al.) (December 2012). Effect of tart cherry juice (Prunus ce…
2009 mixtape by ThemselvesThe Free HoudiniMixtape by ThemselvesReleasedMarch 25, 2009 (2009-03-25)GenreAlternative hip hopLength54:42LabelAnticonProducerJel, DoseoneThemselves chronology The No Music of AIFFs(2003) The Free Houdini(2009) Crowns Down(2009) Professional ratingsAggregate scoresSourceRatingMetacritic74/100[1]Review scoresSourceRatingChristgau's Consumer Guide[2]Cokemachineglowfavorable[3]Exclaim!favorable[4]HipHopDX3.0/5[5…
Art movement A Sunday Afternoon on the Island of La Grande JatteArtistGeorges SeuratYear1884–1886MediumOil on canvasDimensions207.6 cm × 308 cm (81.7 in × 121.3 in)LocationArt Institute of Chicago, Chicago Neo-Impressionism is a term coined by French art critic Félix Fénéon in 1886 to describe an art movement founded by Georges Seurat. Seurat's most renowned masterpiece, A Sunday Afternoon on the Island of La Grande Jatte, marked the beginning of …
German rapper, singer-songwriter This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.Find sources: Max Herre – news · newspapers · books · scholar · JSTOR (August 2014) (Learn how and when to remove this template me…
この項目では、近代の創作物に登場する女性の忍者について説明しています。 女子サッカーチームについては「伊賀FCくノ一三重」をご覧ください。 スポーツバラエティー番組については「KUNOICHI」をご覧ください。 くノ一(くのいち)は、女を指す隠語[1][2]。1960年代以降の創作物においては女忍者を指す言葉として広まっている。 山田風太郎の時代小説『…
Xiaomi CiviXiaomi Civi 1S Передня частина Xiaomi CiviКодове ім'я Civi: monaCivi 1S: zijinБренд XiaomiВиробник XiaomiГасло Civi: Народжений, щоб добре виглядатиCivi 1S: Ваше світло народжується прекраснимКольори чорний, синій і рожевийСерія CiviМодель Civi: 2109119BCCivi 1S: 2204119ECСумісні мережі GSM, 3G, 4G (LTE), 5GДата пред…
2020 single by Jonas Brothers What a Man Gotta DoSingle by Jonas BrothersReleasedJanuary 17, 2020 (2020-01-17)Length3:00LabelRepublicSongwriter(s) Nicholas Jonas Joseph Jonas Kevin Jonas II Ryan Tedder David Stewart Jessica Agombar Producer(s) Ryan Tedder David Stewart Jonas Brothers singles chronology Like It's Christmas (2019) What a Man Gotta Do (2020) X / Five More Minutes(2020) Music videoWhat a Man Gotta Do on YouTube What a Man Gotta Do is a song by American pop rock group …
Extinct script This article is in list format but may read better as prose. You can help by converting this article, if appropriate. Editing help is available. (January 2021) Bosnian CyrillicScript type Alphabet Cyrillic scriptTime period10th–19th centuryLanguagesSerbo-Croatian This article contains phonetic transcriptions in the International Phonetic Alphabet (IPA). For an introductory guide on IPA symbols, see Help:IPA. For the distinction between [ ], / / and ⟨…
Кінешма Кинешма Герб Прапор Країна Росія Суб'єкт Російської Федерації Івановська область Код ЗКАТУ: 24405 Код ЗКТМО: 24705000001 Основні дані Перша згадка: 1429 Статус 1777 Населення 86 067 (2014) Площа 49 км² Поштові індекси 155800 - 155819 Телефонний код +7 49331 Географічні координати: 57°27…
Minnesota's congressional districts from 2023[1] Minnesota is currently divided into eight congressional districts, each represented by a member of the United States House of Representatives. After the 2020 census, the number of Minnesota's seats remained unchanged. Minnesota statutes do not require candidates for the United States House of Representatives to reside in the district in which they run for office, but candidates must be inhabitants of the state at the time of the election.&…
João Braz de AvizPrefek Kongregasi bagi Lembaga Hidup Tahbisan dan Masyarakat Kehidupan ApostolikPenunjukan4 Januari 2011PendahuluFranc Rode CMJabatan lainKardinal-Deakonf Sant’Elena fuori Porta PrenestinaImamatTahbisan imam26 November 1972oleh Romeu AlbertiTahbisan uskup31 Mei 1994oleh Domingos Gabriel WisniewskiPelantikan kardinal18 Februari 2012oleh Paus Benediktus XVIPeringkatKardinal-DeakonInformasi pribadiNama lahirJoão Braz de AvizLahir24 April 1947 (umur 76)Mafra, Bras…
This article is about the Jamiroquai song. For the song by The Rakes, see Capture/Release. 2017 single by JamiroquaiAutomaton10-inch vinyl cover artSingle by Jamiroquaifrom the album Automaton B-sideNights Out in the JungleReleased27 January 2017Recorded2015–2016StudioChillington (Buckinghamshire, England)AIR (London)[1]GenreDiscofunksynthpopdance-popLength4:48LabelVirgin EMISongwriter(s)Matt JohnsonJay KayProducer(s)Matt JohnsonJay KayJamiroquai singles chronology Lifeline (2011) Auto…
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