Protein-coding gene in the species Homo sapiens
DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene .[ 5] [ 6] DNA polymerase delta complex.
Interactions
POLD3 has been shown to interact with PCNA .[ 7] [ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000077514 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030726 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts" . Nucleic Acids Res . 27 (10): 2108– 14. doi :10.1093/nar/27.10.2108 . PMC 148430 PMID 10219083 . ^ "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit" .^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta" . J. Biol. Chem . 276 (52): 49258– 66. doi :10.1074/jbc.M106990200 PMID 11595739 . ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein" . J. Biol. Chem . 277 (43): 40362– 7. doi :10.1074/jbc.M206194200 PMID 12171929 .
Further reading
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1" . DNA Res . 1 (1): 27– 35. doi :10.1093/dnares/1.1.27 PMID 7584026 . Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY (1994). "DNA polymerase delta is involved in the cellular response to UV damage in human cells" . J. Biol. Chem . 269 (19): 13748– 51. doi :10.1016/S0021-9258(17)36709-1 PMID 7910606 . Longley MJ, Pierce AJ, Modrich P (1997). "DNA polymerase delta is required for human mismatch repair in vitro" . J. Biol. Chem . 272 (16): 10917– 21. doi :10.1074/jbc.272.16.10917 PMID 9099749 . Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry . 39 (24): 7245– 54. doi :10.1021/bi0000871 . PMID 10852724 . Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2002). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta" . J. Biol. Chem . 276 (52): 49258– 66. doi :10.1074/jbc.M106990200 PMID 11595739 . Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein" . J. Biol. Chem . 277 (43): 40362– 7. doi :10.1074/jbc.M206194200 PMID 12171929 . Pohler JR, Otterlei M, Warbrick E (2006). "An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit" . BMC Mol. Biol . 6 : 17. doi :10.1186/1471-2199-6-17 PMC 1187890 PMID 16000169 . Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y (2006). "Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase". Biochim. Biophys. Acta . 1764 (9): 1447– 53. doi :10.1016/j.bbapap.2006.06.015 . PMID 16935576 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K (2007). "Dynamics of human replication factors in the elongation phase of DNA replication" . Nucleic Acids Res . 35 (20): 6904– 16. doi :10.1093/nar/gkm822 . PMC 2175312 PMID 17932049 .
