RNASEH1

RNASEH1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNASEH1, H1RNA, RNH1, PEOB2, ribonuclease H1
External IDsOMIM: 604123; MGI: 1335073; HomoloGene: 2202; GeneCards: RNASEH1; OMA:RNASEH1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

246243

19819

Ensembl

ENSG00000171865

ENSMUSG00000020630

UniProt

O60930

E9QLN8

RefSeq (mRNA)

NM_001286865
NM_011275

RefSeq (protein)

NP_001273794
NP_035405

Location (UCSC)Chr 2: 3.54 – 3.56 MbChr 12: 28.7 – 28.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene.[5][6][7] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171865 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020630 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ribonuclease H1".
  6. ^ ten Asbroek AL, van Groenigen M, Jakobs ME, Koevoets C, Janssen B, Baas F (June 2002). "Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome". Genomics. 79 (6): 818–23. doi:10.1006/geno.2002.6776. PMID 12036296.
  7. ^ Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (October 2007). "Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription". Mol. Cell. 28 (2): 264–76. doi:10.1016/j.molcel.2007.08.015. PMID 17964265.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: O60930 (Human Ribonuclease H1 (RNASEH1)) at the PDBe-KB.


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