4998
18392
ENSG00000085840
ENSMUSG00000028587
Q13415
Q9Z1N2
NM_001190818NM_001190819NM_004153
NM_001014425NM_011015
NP_001177747NP_001177748NP_004144
NP_035145
Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene.[5][6] It is closely related to CDC6, and both are the same protein in archaea.[7]
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of the pre-replication complex, which includes additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the origin recognition complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MYST2/HBO1), a protein involved in control of transcription silencing.[6]
ORC1 has been shown to interact with:
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