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KRT85
Identifiers
Aliases	KRT85, ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5, keratin 85
External IDs	OMIM: 602767; MGI: 1859268; HomoloGene: 37603; GeneCards: KRT85; OMA:KRT85 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,367,481 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,422,054 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; sperm; ; testicle; ; skin of hip; ; hair follicle; ; skin of thigh; ; nipple; ; gonad; ; right lung; ; skin of abdomen;
	Top expressed in
	lip; ; zone of skin; ; testicle; ; spermatid; ; limb; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; keratin filament; extracellular space; cytosol;
Biological process	epidermis development; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3891
	53622
	ENSG00000135443
	ENSMUSG00000116336
	P78386
	Q9Z2T6
	NM_002283; NM_001300810
	NM_016879
	NP_001287739; NP_002274
	NP_058575
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135443 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000116336 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J (Apr 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation. 61 (3): 187–94. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT85 keratin 85".