3887
64818
ENSG00000205426
ENSMUSG00000067615
Q14533
Q9ERE2
NM_002281
NM_001166157
NP_002272
NP_001159629
Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.[5][6][7]
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.[7]
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
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