DCTN1

DCTN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TXQ, 2COY, 2HKN, 2HKQ, 2HL3, 2HL5, 2HQH, 3E2U, 3TQ7
Identifiers
Aliases	DCTN1, DAP-150, DP-150, P135, dynactin subunit 1
External IDs	OMIM: 601143; MGI: 107745; HomoloGene: 3011; GeneCards: DCTN1; OMA:DCTN1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,392,087 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,177,099 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; right hemisphere of cerebellum; ; apex of heart; ; anterior cingulate cortex; ; nucleus accumbens; ; amygdala; ; putamen; ; caudate nucleus; ; anterior pituitary;
	Top expressed in
	neural layer of retina; ; entorhinal cortex; ; perirhinal cortex; ; CA3 field; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; muscle of thigh; ; central gray substance of midbrain;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cytoskeletal motor activity; microtubule binding; tubulin binding; dynein complex binding; protein kinase binding; tau protein binding;
Cellular component	cytoplasm; centrosome; membrane; dynactin complex; retromer complex; cell leading edge; dynein complex; microtubule; cytoskeleton; kinetochore; microtubule organizing center; nucleus; nuclear envelope; centriole; spindle; cytosol; actin cytoskeleton; microtubule plus-end; spindle pole; cell cortex region; cell cortex; microtubule associated complex; axon; neuron projection; neuronal cell body; intermediate filament cytoskeleton; centriolar subdistal appendage;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; nervous system development; endoplasmic reticulum to Golgi vesicle-mediated transport; transport along microtubule; IRE1-mediated unfolded protein response; retrograde transport, endosome to Golgi; G2/M transition of mitotic cell cycle; melanosome transport; centriole-centriole cohesion; positive regulation of microtubule polymerization; microtubule anchoring at centrosome; nuclear membrane disassembly; positive regulation of microtubule nucleation; ciliary basal body-plasma membrane docking; non-motile cilium assembly; mitotic cell cycle; establishment of mitotic spindle orientation; regulation of mitotic spindle organization; cell cycle; cell division; regulation of G2/M transition of mitotic cell cycle; transport; neuromuscular junction development; ventral spinal cord development; neuromuscular process; motor behavior; neuron cellular homeostasis; axonal transport; maintenance of synapse structure; positive regulation of neuromuscular junction development; neuron projection maintenance;
	Sources:Amigo / QuickGO
Orthologs
	1639
	13191
	ENSG00000204843
	ENSMUSG00000031865
	Q14203
	O08788
NM_001135040; NM_001135041; NM_001190836; NM_001190837; NM_004082;
	NM_023019; NM_001378991; NM_001378992
	NM_001198866; NM_001198867; NM_007835; NM_001347310
NP_001128512; NP_001128513; NP_001177765; NP_001177766; NP_004073;
	NP_075408; NP_001365920; NP_001365921
	NP_001185795; NP_001185796; NP_001334239; NP_031861
	Wikidata
View/Edit Human	View/Edit Mouse

Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene.^[5]

Function

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD).^[6] Dynactin binds to cytoplasmic dynein, dynein cargo adaptors, and microtubules.^[7] It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.

This subunit is commonly referred to p150-glued.^[5] It is present in two copies per dynactin complex and forms an ≈75 nm long flexible arm that extends from the main body of dynactin.^[6] The p150-glued arm contains binding sites for microtubules,^[8] the microtubule plus tip binding protein EB1,^[9] and the N-terminus of the dynein intermediate chain.^[10]^[11]

Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.^[12]