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KRT17
Identifiers
Aliases	KRT17, K17, PC, PC2, PCHC1, 39.1, CK-17, keratin 17
External IDs	OMIM: 148069; MGI: 96691; HomoloGene: 363; GeneCards: KRT17; OMA:KRT17 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,624,842 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,151,855 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; olfactory zone of nasal mucosa; ; amniotic fluid; ; vulva; ; skin of thigh; ; hair follicle; ; skin of arm; ; skin of abdomen; ; nipple; ; buccal mucosa cell;
	Top expressed in
	lip; ; molar; ; skin of back; ; epidermis; ; hair follicle; ; skin of external ear; ; skin of abdomen; ; thymus; ; corneal stroma; ; hair;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; MHC class II receptor activity; protein binding; structural molecule activity; MHC class II protein binding;
Cellular component	cytoplasm; extracellular exosome; intermediate filament; cell periphery; cytosol; intermediate filament cytoskeleton;
Biological process	morphogenesis of an epithelium; positive regulation of hair follicle development; hair follicle morphogenesis; intermediate filament organization; positive regulation of cell growth; positive regulation of translation; signal transduction; epidermis development; keratinization; cornification; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	3872
	16667
	ENSG00000128422
	ENSMUSG00000035557
	Q04695
	Q9QWL7
	NM_000422
	NM_010663
	NP_000413
	NP_034793
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.^[5]^[6]^[7]^[8]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.^[8]

Interactions

Keratin 17 has been shown to interact with CCDC85B.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128422 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035557 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O, Dopping-Hepenstal PJ, Griffiths WA, Eady RA, Higgins C (Jul 1995). "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat Genet. 9 (3): 273–8. doi:10.1038/ng0395-273. PMID 7539673. S2CID 1873772.
^ Troyanovsky SM, Leube RE, Franke WW (Jan 1993). "Characterization of the human gene encoding cytokeratin 17 and its expression pattern". Eur J Cell Biol. 59 (1): 127–37. PMID 1281771.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT17 keratin 17".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.