PROFILPELAJAR.COM

GYKI-13380

GYKI-13380
Clinical data
Other namesGYKI13380; LS-79445; LS79445
Drug classPhosphodiesterase inhibitor; Possible other actions; Appetite suppressant
ATC code
  • None
Identifiers
  • 4-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]imidazolidin-2-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H22N2O3
Molar mass290.363 g·mol−1
3D model (JSmol)
  • COC1=C(C=C(C=C1)CC2CNC(=O)N2)OC3CCCC3
  • InChI=1S/C16H22N2O3/c1-20-14-7-6-11(8-12-10-17-16(19)18-12)9-15(14)21-13-4-2-3-5-13/h6-7,9,12-13H,2-5,8,10H2,1H3,(H2,17,18,19)
  • Key:YOFWLAASFMHLAD-UHFFFAOYSA-N

GYKI-13380 is an experimental appetite suppressant of the phenethylamine and amphetamine families which was never marketed.[1] It is a cyclized phenethylamine, with the amine and α position of the side chain cyclized into an imidazolidinone moiety.[1]

The drug potently suppresses appetite in rodents.[1] It does not produce psychostimulant effects in rats, is not self-administered in rats, and does not produce pulmonary hypertension in dogs or cats.[1] Instead, mild sedation was reported at relatively high doses.[1] Accordingly, GYKI-13380 did not substitute for dextroamphetamine in rodent drug discrimination tests.[1] On the other hand however, it fully substituted for fenfluramine in rodent drug discrimination tests.[1] It is unclear whether GYKI-13380 and fenfluramine act via common mechanisms of action.[1] It is known that GYKI-13380 may act in part as a phosphodiesterase inhibitor, but other potential actions of the drug, such as on the serotonin system, have not been evaluated.[1]

GYKI-13380 was first described in the literature in 1978 and was further described up to 1982.[1][2][3][4][5] Subsequently, it was characterized and described in greater detail in 2022.[1]

See also

References

  1. ^ a b c d e f g h i j k Young, Richard (2022). "Discriminative stimulus effects of an imidazolidine-derived appetite suppressant". Medicinal Chemistry Research. 31 (4): 545–554. doi:10.1007/s00044-022-02853-7. ISSN 1054-2523. Retrieved 20 July 2026.
  2. ^ Schneider G, Andrási F, Berzsenyi P, Lázár A, Elek S, Elekes I, et al. Inventors; 4-[(3,4-Dialkoxyphenyl)alkyl]-2-Imidazolidinone Derivatives and Processes for the Preparation Thereof. HU 1978-G601429. 1978, November, 01.
  3. ^ Schneider G, Andrási F, Berzsenyi P, Lázár A, Elek S, Elekes I, et al. Inventors; 4-[(3,4-Dialkoxyphenyl)alkyl]-2-Imidazolidinone Derivatives and Processes for the Preparation Thereof. GB 2,036,010. 1980, June, 25.
  4. ^ Schneider G, Andrási F, Berzsenyi P, Lázár A, Elek S, Elekes I, et al. Inventors; Anorexigenic 4-[(3,4-Dialkoxyphenyl)alkyl]-2- Imidazolidinone Derivatives. DE 2943877; HU 179019; US Patent 4,308,278. 1981, December, 29.
  5. ^ Andrási F, Berzsenyi P, Schneider G. Investigations with a new appetite suppressant. Neurosci Lett. 1982;10:44.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.