Serdexmethylphenidate

Not to be confused with serdexmethylphenidate/dexmethylphenidate.

Serdexmethylphenidate
Skeletal formula of serdexmethylphenidate
Clinical data
Other namesSDX
License data
Routes of
administration		By mouth
ATC code
  • None
Legal status
Legal status
Pharmacokinetic data
Bioavailability< 3% (absolute oral)[2]
MetabolitesDexmethylphenidate, ritalinic acid[2]
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC25H29N3O8
Molar mass499.520 g·mol−1
3D model (JSmol)
  • COC(=O)C(C1CCCCN1C(=O)OC[N+]2=CC=CC(=C2)C(=O)NC(CO)C(=O)[O-])C3=CC=CC=C3

  • COC(=O)[C@@H]([C@H]1CCCCN1C(=O)OC[N+]2=CC=CC(=C2)C(=O)N[C@@H](CO)C(=O)O)C3=CC=CC=C3.[Cl-]
  • InChI=1S/C25H29N3O8/c1-35-24(33)21(17-8-3-2-4-9-17)20-11-5-6-13-28(20)25(34)36-16-27-12-7-10-18(14-27)22(30)26-19(15-29)23(31)32/h2-4,7-10,12,14,19-21,29H,5-6,11,13,15-16H2,1H3,(H-,26,30,31,32)/t19-,20+,21+/m0/s1
  • Key:UBZPNQRBUOBBLN-PWRODBHTSA-N

  • InChI=1S/C25H29N3O8.ClH/c1-35-24(33)21(17-8-3-2-4-9-17)20-11-5-6-13-28(20)25(34)36-16-27-12-7-10-18(14-27)22(30)26-19(15-29)23(31)32;/h2-4,7-10,12,14,19-21,29H,5-6,11,13,15-16H2,1H3,(H-,26,30,31,32);1H/t19-,20+,21+;/m0./s1
  • Key:GONQEUJYYMYNMN-HWAJWLCKSA-N
  (verify)

Serdexmethylphenidate is a prodrug of dexmethylphenidate created by the pharmaceutical company KemPharm (now Zevra Therapeutics). The compound was first approved by the FDA as one of the active ingredients in Azstarys for the treatment of attention deficit hyperactivity disorder (ADHD) in children, adolescents, and adults in March 2021.[2][3] Serdexmethylphenidate is a prodrug which has a delayed onset of action and a prolonged duration of effects compared to dexmethylphenidate, its parent compound.

Medical uses

Azstarys capsules containing 52.3mg serdexmethylphenidate chloride, 10.4mg dexmethylphenidate chloride

The combination serdexmethylphenidate/dexmethylphenidate (Azstarys) was approved by the Food and Drug Administration (FDA) in March 2021, for the treatment of ADHD in people six years of age and older.[2] Co-formulation of serdexmethylphenidate with dexmethylphenidate allows for a more rapid onset of action while still retaining up to 13 hours of therapeutic efficacy.[4][5]

Society and culture

Abuse potential

The abuse potential of serdexmethylphenidate has been evaluated in clinical studies.[6] Administration of serdexmethylphenidate via common routes of administration used during the abuse of psychostimulants such as insufflation and intravenous injection resulted in significantly reduced systemic exposure to active dexmethylphenidate and thus markedly decreased pharmacodynamic effects when compared to unmodified dexmethylphenidate.[7]

Following an Eight Factor Analysis by the FDA Controlled Substance Staff (CSS), the U.S. Department of Health and Human Services (HHS) provided a scheduling recommendation to the Drug Enforcement Administration (DEA) to control serdexmethylphenidate and its salts in schedule IV of the Controlled Substances Act (CSA). Based on this recommendation and its own review, the DEA concluded that serdexmethylphenidate met the criteria for placement in schedule IV of the CSA.[6][8]

Research

Due to the delayed onset and prolonged duration of effects following oral administration of serdexmethylphenidate, several dosage forms containing serdexmethylphenidate are under investigation for use as long-acting psychostimulant in the treatment of various CNS disorders, substance use disorder (SUD), and sleep disorders.[9] Under the developmental codename KP484, serdexmethylphenidate is being investigated as part of a potential "super-extended duration" psychostimulant, with therapeutic efficacy lasting up to 16 hours following oral administration.[9]

In January 2021, the FDA granted approval for clinical trials investigating serdexmethylphenidate (as KP879) for the treatment for stimulant use disorder.[10]

References

  1. ^ "Schedules of Controlled Substances: Placement of Serdexmethylphenidate in Schedule IV". Federal Register. 24 June 2022. Retrieved 4 May 2024.
  2. ^ a b c d "Azstarys- serdexmethylphenidate and dexmethylphenidate capsule". DailyMed. 3 November 2022. Retrieved 13 April 2023.
  3. ^ KemPharm (3 March 2021). "KemPharm Announces FDA Approval of Azstarys (serdexmethylphenidate and dexmethylphenidate capsules, for oral use, CII), A New Once-Daily Treatment for ADHD" (Press release). KemPharm. Retrieved 17 May 2021 – via GlobeNewswire.
  4. ^ Mickle T. "Prodrugs for ADHD Treatments: Opportunities & Potential to Fill Unmet Medical Needs" (PDF). Archived from the original (PDF) on 21 November 2020. Retrieved 15 November 2020.
  5. ^ Bastings E (2 March 2021). "NDA 212994 Approval" (PDF). U.S. Food and Drug Administration (FDA). Retrieved 6 March 2021.
  6. ^ a b "Schedules of Controlled Substances: Placement of Serdexmethylphenidate in Schedule IV". Federal Register. 7 May 2021. Retrieved 17 May 2021.
  7. ^ Braeckman R (1 October 2018). "Human Abuse Potential of Intravenous Serdexmethylphenidate (SDX), A Novel Prodrug of D-Methylphenidate, in Recreational Stimulant Abusers". Journal of the American Academy of Child & Adolescent Psychiatry. 57 (10): 176. doi:10.1016/j.jaac.2018.09.141. S2CID 149510614. Retrieved 15 November 2020.
  8. ^ "Schedules of Controlled Substances: Placement of Serdexmethylphenidate in Schedule IV". Federal Register. 24 June 2022. Retrieved 13 April 2023.
  9. ^ a b "Pipeline & Products". Kempharm Inc. Archived from the original on 17 May 2021. Retrieved 17 May 2021.
  10. ^ "KemPharm Receives FDA Clearance to Initiate KP879 Clinical Program for the Treatment of Stimulant Use Disorder" (Press release). KemPharm. 27 January 2021. Retrieved 23 April 2021 – via GlobeNewswire News Room.