2022 San Luis Open Challenger
Date	11–17 April
Edition	27th
Surface	Clay
Location	San Luis Potosí, Mexico
Champions
Singles
Antoine Bellier
Doubles
Nicolás Barrientos / Miguel Ángel Reyes-Varela
← 2019 · San Luis Open Challenger · 2023 →

The 2022 San Luis Open Challenger was a professional tennis tournament played on clay courts. It was the 27th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in San Luis Potosí, Mexico between 11 and 17 April 2022.

Country	Player	Rank1	Seed
SVK	Andrej Martin	129	1
CHI	Nicolás Jarry	139	2
USA	Ernesto Escobedo	142	3
ARG	Facundo Mena	159	4
GBR	Jay Clarke	166	5
SUI	Marc-Andrea Hüsler	176	6
ITA	Federico Gaio	186	7
ARG	Renzo Olivo	203	8

• ¹ Rankings are as of 4 April 2022.^[1]

The following players received wildcards into the singles main draw:

• Alex Hernández
• Shintaro Mochizuki
• Rodrigo Pacheco Méndez

The following players received entry into the singles main draw as alternates:

• Viktor Durasovic
• Peđa Krstin

The following players received entry from the qualifying draw:

• Antoine Bellier
• Hady Habib
• Gilbert Klier Júnior
• Roberto Quiroz
• Shang Juncheng
• Matías Zukas

• Antoine Bellier def. Renzo Olivo 6–7^(2–7), 6–4, 7–5.

• Nicolás Barrientos / Miguel Ángel Reyes-Varela def. Luis David Martínez / Felipe Meligeni Alves 7–6^(13–11), 6–2.