Singles
2022 San Luis Open Challenger
Final
Champion	Antoine Bellier
Runner-up	Renzo Olivo
Score	6–7(2–7), 6–4, 7–5
Events
Singles Doubles
← 2019 · San Luis Open Challenger · 2023 →

Marc-Andrea Hüsler was the defending champion^[1] but lost in the semifinals to Antoine Bellier.

Bellier won the title after defeating Renzo Olivo 6–7^(2–7), 6–4, 7–5 in the final.

	Semifinals							Final
	Q	Antoine Bellier	2	6	6
	6	Marc-Andrea Hüsler	6	3	3
								Q	Antoine Bellier	62	6	7
								8	Renzo Olivo	77	4	5
	8	Renzo Olivo	6	6
	2	Nicolás Jarry	3	2

	First round							Second round							Quarterfinals							Semifinals
	1	A Martin	6	6
		J Lenz	1	1				1	A Martin	2	6	6
		N Kuhn	77	5	6				N Kuhn	6	4	4
		JP Ficovich	62	7	3										1	A Martin	3	4
		FC Jianu	3	6	5										Q	A Bellier	6	6
	Q	A Bellier	6	3	7			Q	A Bellier	6	1	6
	Alt	P Krstin	2	6	5			7	F Gaio	3	6	3
	7	F Gaio	6	2	7																	Q	A Bellier	2	6	6
	4	F Mena	63	1																		6	M-A Hüsler	6	3	3
		Zh Zhang	77	6					Zh Zhang	7	64	6
		N Mejía	7	63	77				N Mejía	5	77	3
	Alt	V Durasovic	5	77	63											Zh Zhang	4	6	3
	Q	J Shang	4	77	6										6	M-A Hüsler	6	3	6
	Q	H Habib	6	61	2			Q	J Shang	4	66
	Q	R Quiroz	61	3				6	M-A Hüsler	6	78
	6	M-A Hüsler	77	6

	First round							Second round							Quarterfinals							Semifinals
	8	R Olivo	6	3	6
		A Cazaux	4	6	4			8	R Olivo	5	6	6
		G Oliveira	6	7					G Oliveira	7	3	2
	WC	S Mochizuki	4	5											8	R Olivo	6	2	6
		M Pucinelli de Almeida	77	1	3										3	E Escobedo	4	6	4
		D Istomin	63	6	6				D Istomin	4	6	3
	WC	A Hernández	4	2				3	E Escobedo	6	4	6
	3	E Escobedo	6	6																		8	R Olivo	6	6
	5	J Clarke	6	6																		2	N Jarry	3	2
	Q	Matías Zukas	3	4				5	J Clarke	4	0
		F Meligeni Alves	77	6					F Meligeni Alves	6	6
		E Donskoy	62	3												F Meligeni Alves	6	4	5
	Q	Gilbert Klier Júnior	79	6											2	N Jarry	4	6	7
	WC	R Pacheco Méndez	67	4				Q	G Klier Júnior	78	4	4
		G Melzer	6	3	64			2	N Jarry	66	6	6
	2	N Jarry	2	6	77

• Main draw
• Qualifying draw