The 2022 Tiburon Challenger was a professional tennis tournament played on outdoor hard courts. It was the fourteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Tiburon, United States between October 3 and October 9, 2022.
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
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