The 2022 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 26 September and 2 October 2022.
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
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