The 2022 Open Comunidad de Madrid was a professional tennis tournament played on clay courts. It was the 1st edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Madrid, Spain between 11 and 17 April 2022.
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
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