2022 Santa Cruz Challenger II
Date	21–27 March
Edition	2nd
Surface	Clay
Location	Santa Cruz de la Sierra, Bolivia
Champions
Singles
Paul Jubb
Doubles
Jesper de Jong / Bart Stevens
← 2022 · Santa Cruz Challenger · 2023 →

The 2022 Santa Cruz Challenger II, also known as Dove MEN + CARE Bolivia Open^[1] to differentiate it from the previous edition played the same year, was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santa Cruz de la Sierra, Bolivia between 21 and 27 March 2022.

Country	Player	Rank1	Seed
BOL	Hugo Dellien	101	1
URU	Pablo Cuevas	104	2
PER	Juan Pablo Varillas	117	3
ARG	Tomás Martín Etcheverry	123	4
CHI	Tomás Barrios Vera	145	5
ARG	Camilo Ugo Carabelli	175	6
ARG	Facundo Mena	183	7
NED	Jesper de Jong	189	8

• ¹ Rankings are as of 14 March 2022.^[2]

The following players received wildcards into the singles main draw:

• Pablo Cuevas
• Murkel Dellien
• Juan Carlos Prado Ángelo

The following players received entry into the singles main draw as alternates:

• Nick Hardt
• Johan Nikles

The following players received entry from the qualifying draw:

• Nicolás Barrientos
• Corentin Denolly
• Gilbert Klier Júnior
• Naoki Nakagawa
• Yshai Oliel
• Juan Bautista Torres

The following players received entry as lucky losers:

• Daniel Dutra da Silva
• Facundo Juárez
• Gonzalo Villanueva

• Paul Jubb def. Juan Pablo Varillas 6–3, 7–6^(7–5).

• Jesper de Jong / Bart Stevens def. Nicolás Barrientos / Miguel Ángel Reyes-Varela 6–4, 3–6, [10–6].