阿登·帕塔普蒂安

阿登·帕塔普蒂安2021年诺贝尔生理学或医学奖得主
Արտեմ Փաթափութեան
出生 (1967-10-02) 1967年10月2日（57歲）
 黎巴嫩贝鲁特
职业
奖项诺贝尔生理学或医学奖（2021）
學術背景
教育程度
學術工作
研究機構斯克里普斯研究所

阿登·帕塔普蒂安（英語：Ardem Patapoutian，亞美尼亞語：Արտեմ Փաթափութեան，羅馬化：Ardem P'at'ap'ut'ean，1967年10月2日—），黎巴嫩出生的亚美尼亚裔美籍分子生物学家、神经科学家，任职于加利福尼亚州拉霍亚斯克里普斯研究所，2021年获诺贝尔生理学或医学奖[1] 。

教育

帕塔普蒂安在1986年移民美国前就读于贝鲁特美国大学，他于1990年获加利福尼亚大学洛杉矶分校细胞与发育生物学学士学位，1996年获加州理工学院生物学博士学位，之后在加利福尼亚大学旧金山分校与路易斯·F·赖查特（Louis F. Reichardt）进行博士后研究。2000年，出任斯克里普斯研究所助理教授。2000年至2014年，兼任诺华研究基金会（Novartis Research Foundation）研究员。2014年起，任霍华德·休斯医学研究所研究员[2]。

研究方向

帕塔普蒂安研究传感器的信号转导[3]，曾发现温度、机械力或体积增加的细胞可以激活新型离子通道PIEZO1（英语：PIEZO1）与PIEZO2和受体。他与同事证明了这些离子通道在温度感、触感、本体感觉、疼痛感及血管张力（英语：Vascular resistance）调节方面起到重要作用。这些发现可以用来治疗慢性疼痛等疾病[4]。最近的研究为利用基因组学技术识别表征机械敏感离子通道（机械转导）[5][6][7][8][9]。

奖项与荣誉

2021年諾貝爾生理學或醫學獎：TRPV1和PIEZO2的發現

2016年，帕塔普蒂安任美国科学促进会会士，2017年任美国国家科学院院士[10]，2020年任美国文理科学院院士[11]。2017年，帕塔普蒂安获W·奥尔登·斯宾塞奖（英语：W. Alden Spencer Award）[12]，2019年获罗森斯蒂尔奖（英语：Rosenstiel Award）[13]，2020年获神经科学科维理奖[14][15]和BBVA基金会知识前沿奖（英语：BBVA Foundation Frontiers of Knowledge Award）生物学/生物医学奖[16]。

2021年，他与戴维·朱利叶斯因发现温度和触觉受体，一同获得诺贝尔生理学或医学奖[3]。

著作

  • Syeda, Ruhma; Qiu, Zhaozhu; Dubin, Adrienne E.; Murthy, Swetha E.; Florendo, Maria N.; Mason, Daniel E.; Mathur, Jayanti; Cahalan, Stuart M.; Peters, Eric C.; Montal, Mauricio; Patapoutian, Ardem. LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. Cell. 2016-01-28, 164 (3): 499–511 [2021-10-04]. ISSN 1097-4172. PMC 4733249 可免费查阅. PMID 26824658. doi:10.1016/j.cell.2015.12.031. （原始内容存档于2021-06-03）. 
  • Ranade, Sanjeev S.; Woo, Seung-Hyun; Dubin, Adrienne E.; Moshourab, Rabih A.; Wetzel, Christiane; Petrus, Matt; Mathur, Jayanti; Bégay, Valérie; Coste, Bertrand; Mainquist, James; Wilson, A. J. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature. December 2014, 516 (7529): 121–125 [2021-10-04]. ISSN 1476-4687. doi:10.1038/nature13980. （原始内容存档于2019-11-05） （英语）. 
  • Qiu, Zhaozhu; Dubin, Adrienne E.; Mathur, Jayanti; Tu, Buu; Reddy, Kritika; Miraglia, Loren J.; Reinhardt, Jürgen; Orth, Anthony P.; Patapoutian, Ardem. SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel. Cell (Elsevier BV). 2014, 157 (2): 447–458. ISSN 0092-8674. doi:10.1016/j.cell.2014.03.024. 
  • Woo, Seung-Hyun; Ranade, Sanjeev; Weyer, Andy D.; Dubin, Adrienne E.; Baba, Yoshichika; Qiu, Zhaozhu; Petrus, Matt; Miyamoto, Takashi; Reddy, Kritika; Lumpkin, Ellen A.; Stucky, Cheryl L.; Patapoutian, Ardem. Piezo2 is required for Merkel-cell mechanotransduction. Nature (Springer Science and Business Media LLC). 2014-04-06, 509 (7502): 622–626. ISSN 0028-0836. doi:10.1038/nature13251. 
  • Coste, Bertrand; Xiao, Bailong; Santos, Jose S.; Syeda, Ruhma; Grandl, Jörg; Spencer, Kathryn S.; Kim, Sung Eun; Schmidt, Manuela; Mathur, Jayanti; Dubin, Adrienne E.; Montal, Mauricio; Patapoutian, Ardem. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (Springer Science and Business Media LLC). 2012-02-19, 483 (7388): 176–181. ISSN 0028-0836. doi:10.1038/nature10812. 
  • Kim, Sung Eun; Coste, Bertrand; Chadha, Abhishek; Cook, Boaz; Patapoutian, Ardem. The role of Drosophila Piezo in mechanical nociception. Nature (Springer Science and Business Media LLC). 2012-02-19, 483 (7388): 209–212. ISSN 0028-0836. doi:10.1038/nature10801. 
  • Coste, B.; Mathur, J.; Schmidt, M.; Earley, T. J.; Ranade, S.; Petrus, M. J.; Dubin, A. E.; Patapoutian, A. Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels. Science (American Association for the Advancement of Science (AAAS)). 2010-09-02, 330 (6000): 55–60. ISSN 0036-8075. doi:10.1126/science.1193270. 

参考资料

  1. ^ David Julius, Ardem Patapoutian win 2021 Nobel Prize in Medicine for discoveries of receptors for temperature and touch. India Today. 2021-10-04 [2021-10-04]. （原始内容存档于2022-10-17） （英语）. 
  2. ^ Ardem Patapoutian. www.kavliprize.org. 2021-03-12 [2021-10-04]. （原始内容存档于2021-06-24）. 
  3. ^ 3.0 3.1 The Nobel Prize in Physiology or Medicine 2021. NobelPrize.org. [2021-10-04]. （原始内容存档于2021-10-04） （美国英语）. 
  4. ^ Medizin-Nobelpreis – US-Forscher David Julius und Ardem Patapoutian ausgezeichnet. Deutschlandfunk. 2019-04-15 [2021-10-04]. （原始内容存档于2021-10-04） （德语）. 
  5. ^ Ardem Patapoutian. Scripps Research. [2021-10-04]. （原始内容存档于2021-02-02）. 
  6. ^ Piezo channels in mechanotransduction: Sensory biology to disease - Ardem Patapoutian. Wu Tsai Neurosciences Institute. 2019-12-17 [2021-10-04]. （原始内容存档于2021-10-04）. 
  7. ^ Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C; Engels, Ingo H; Petrassi, H Michael; Schumacher, Andrew M; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem. Chemical activation of the mechanotransduction channel Piezo1. eLife (eLife Sciences Publications, Ltd). 2015-05-22, 4. ISSN 2050-084X. doi:10.7554/elife.07369. 
  8. ^ Woo, Seung-Hyun; Lukacs, Viktor; de Nooij, Joriene C; Zaytseva, Dasha; Criddle, Connor R; Francisco, Allain; Jessell, Thomas M; Wilkinson, Katherine A; Patapoutian, Ardem. Piezo2 is the principal mechanotransduction channel for proprioception. Nature Neuroscience (Springer Science and Business Media LLC). 2015-11-09, 18 (12): 1756–1762. ISSN 1097-6256. doi:10.1038/nn.4162. 
  9. ^ Murthy, Swetha E.; Dubin, Adrienne E.; Patapoutian, Ardem. Piezos thrive under pressure: mechanically activated ion channels in health and disease. Nature Reviews Molecular Cell Biology (Springer Science and Business Media LLC). 2017-10-04, 18 (12): 771–783. ISSN 1471-0072. doi:10.1038/nrm.2017.92. 
  10. ^ Ardem Patapoutian. www.nasonline.org. [2021-10-04]. （原始内容存档于2020-06-03）. 
  11. ^ Members Elected in 2020. American Academy of Arts & Sciences. [2021-10-04]. （原始内容存档于2021-01-22）. 
  12. ^ The Thirty-Ninth Annual W. Alden Spencer Award and Lecture. Kavli Institute for Brain Science. 2020-06-04 [2021-10-04]. （原始内容存档于2020-12-27）. 
  13. ^ Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. www.brandeis.edu. [2021-10-04]. （原始内容存档于2021-06-15）. 
  14. ^ 2020 Kavli Prize in Neuroscience. www.kavliprize.org. 2021-03-12 [2021-10-04]. （原始内容存档于2021-06-24）. 
  15. ^ 2010年邵逸夫生命科学与医学奖得奖人荣获2020年「卡夫利神经科学奖」. www.shawprize.org. 邵逸夫奖. 2020-05-28 [2021-10-04]. （原始内容存档于2021-10-04） （中文（中国大陆））. 
  16. ^ Fundación BBVA. FBBVA. [2021-10-04]. （原始内容存档于2021-01-30）. 

外部链接

Scholia上有關阿登·帕塔普蒂安的信息

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