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Proteinska fosfataza 3, katalitička podjedinica, gama izozim
Proteinska fosfataza 3, katalitička podjedinica, gama izozim
Identifikatori
Simbol	PPP3CC
Entrez	5533
HUGO	9316
OMIM	114107
RefSeq	NM_005605
UniProt	P48454
Ostali podaci
EC broj	3.1.3.16
Lokus	Hromozom 8 p21.3

Proteinska fosfataza 3, katalitička podjedinica, beta izozim
Proteinska fosfataza 3, katalitička podjedinica, beta izozim
Identifikatori
Simbol	PPP3CB
Alt. simboli	CALNB
Entrez	5532
HUGO	9315
OMIM	114106
RefSeq	NM_021132
UniProt	P16298
Ostali podaci
EC broj	3.1.3.16
Lokus	Hromozom 10 q22.2

Proteinska fosfataza 3, katalitička podjedinica, alfa izozim
Proteinska fosfataza 3, katalitička podjedinica, alfa izozim
Identifikatori
Simbol	PPP3CA
Alt. simboli	CALN, CALNA
Entrez	5530
HUGO	9314
OMIM	114105
RefSeq	NM_000944
UniProt	Q08209
Ostali podaci
EC broj	3.1.3.16
Lokus	Hromozom 4 q24

Kalcineurin (CN) je proteinska fosfataza, takođe poznata kao proteinska fosfataza 3, i kalcijum-zavisna serin-treoninska fosfataza.^[2]. On aktivira T ćelije imunskog sistema, i može se blokirati lekovima. Kalcineurin aktivira nuklearni faktor aktiviranih T ćelija, citoplazmni (NFATc) transkripcioni faktor, putem njegove defosforilacije. Aktivirani NFATc se zatim translocira u jedro, gde povećava izražavanje interleukina 2 (IL-2), koji zatim stimuliše rast i diferencijaciju T ćelijskog responsa. Kalcineurin je biološki cilj klase lekova pod nazivom kalcineurinski inhibitori, koja obuhvata ciklosporin, pimekrolimus i takrolimus.

Struktura

Kalcineurin je heterodimer od 61-kD kalmodulin-vezujuće katalitičke podjedinice, kalcineurina A i 19-kD Ca²⁺-vezujuće regulatorne podjedinice, kalcineurina B. Postoje tri izozima katalitčke podjedinice, svaka od kojih je kodirana zasebnim genom (PPP3CA, PPP3CB, i PPP3CC) i dve regulatorne izoforme, takođe kodirane zasebnim genima (PPP3R1, PPP3R2).

Proteinska fosfataza 3, regulatorna podjedinica B, alfa
Identifikatori
Simbol	PPP3R1
Entrez	5534
HUGO	9317
OMIM	601302
RefSeq	NM_000945
UniProt	P63098
Ostali podaci
EC broj	3.1.3.16
Lokus	Hromozom 2 p14

Proteinska fosfataza 3, regulatorna podjedinica B, beta
Identifikatori
Simbol	PPP3R2
Entrez	5535
HUGO	9318
OMIM	613821
RefSeq	NM_147180
UniProt	Q96LZ3
Ostali podaci
EC broj	3.1.3.16
Lokus	Hromozom 9 q31

Reference

^ PDB: 1AUI; Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW (1995). „Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex”. Nature. 378 (6557): 641—4. PMID 8524402. doi:10.1038/378641a0.
^ Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L (2005). „Crystal Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis”. Mol Biol Rep. 32 (1): 41—45. PMID 15865209. doi:10.1007/s11033-004-4250-4.

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