Her er en liste over destinasjoner Virgin Atlantic Airways betjener

• Kenya
  • Nairobi (Jomo Kenyatta International Airport) (fra 1. juni 2007)
• Mauritius
  • Port Louis (Sir Seewoosagur Ramgoolam International Airport) (fra november 2007)
• Nigeria
  • Lagos (Murtala Mohammed International Airport)
• Sør-Afrika
  • Cape Town (Cape Town International Airport)
  • Johannesburg (OR Tambo International Airport)

• Kina
  • Hongkong (Hongkong internasjonale lufthavn)
  • Shanghai (Shanghai Pudong International Airport)
• Japan
  • Tokyo (Narita International Airport)

• India
  • Delhi (Indira Gandhi International Airport)
  • Mumbai (Chatrapati Shivaji International Airport)

• De forente arabiske emirater
  • Dubai (Dubai International Airport)

• Storbritannia
  • London
    • (London Heathrow Airport) Hub
    • (London Gatwick Airport) Hub
  • Manchester (Manchester Airport) Focus City
  • Glasgow (Glasgow International Airport) (fra 23. juni 2007/i sommersesongen)

• California
  • Los Angeles (Los Angeles International Airport)
  • San Francisco (San Francisco International Airport)
• Florida
  • Miami (Miami International Airport)
  • Orlando (Orlando International Airport)
• Illinois
  • Chicago (O'Hare International Airport)
• Massachusetts
  • Boston (Logan International Airport)
• Nevada
  • Las Vegas (McCarran International Airport)
• New Jersey
  • Newark (Newark Liberty International Airport)
• New York
  • New York City (John F. Kennedy International Airport)
• Virginia
  • Washington, D.C. (Dulles International Airport)

• Antigua og Barbuda
  • Antigua (VC Bird International Airport)
• Bahamas
  • Nassau (Lynden Pindling International Airport) (til mars 2007)
• Barbados
  • Bridgetown (Grantley Adams International Airport)
• Cuba
  • Havanna (José Martí International Airport)
• Grenada
  • Grenada (Point Salines International Airport)
• Jamaica
  • Montego Bay (Sangster International Airport)
• St Lucia
  • Vieux-Fort (Hewanorra International Airport)
• Trinidad og Tobago
  • Tobago (Crown Point Airport)

• Australia
  • Sydney (Kingsford Smith International Airport)

Fra London Heathrow til: Athen
Fra London Gatwick til: Athen, Boston, Miami, Moskva, New York, Port Harcourt, Toronto, San Francisco