Dermataanisulfaatti

Dermataanisulfaatti
Tunnisteet
CAS-numero 24967-94-0

Dermataanisulfaatti on glykosaminoglykaani, jota tavataan erityisesti ihossa mutta myös muissa kudoksissa käytännöllisesti katsoen lähes jokaisella nisäkkäällä. [1] [2]

Aineesta käytetään myös nimitystä kondroitiinisulfaatti B ja se eroaa kondroitiinisulfaatti A:sta ainoastaan siinä, että kondroitiinisulfaatti A:n glukuronihappo on vaihtunut glukuronihapon epimeeriksi iduronihapoksi. [1] Nykyään ainetta ei kuitenkaan useimmiten luokitella kuuluviksi kondroitiinisulfaatteihin.

Toiminta

Dermataanisulfaatin arvellaan liittyvän karsinogeneesiin, fibroosiin, sydämen ja verisuonten tauteihin sekä tulehduksien ja haavojen parantumiseen.[2]

Dermataanisulfaatti on mukana useissa mukopolysakkaaridooseissa, jotka ovat geenivirheistä aiheutuvia sairauksia. Dermataanisulfaattia kerääntyy elimistöön vaikeassa Hurlerin taudissa[3]

Lähteet

  1. ↑ a b Dermatan Sulfate - Substance summary NCBI. Viitattu 11. marraskuuta 2008.
  2. ↑ a b Trowbridge JM, Gallo RL.: Dermatan sulfate: new functions from an old glycosaminoglycan. 2002. PubMed. Viitattu 11.11.2008.
  3. ↑ Eero Palolampi: Mukopolysakkaridoosit (doc) MLL. Viitattu 11.11.2008.[vanhentunut linkki]

Aiheesta muualla

Hiilihydraatit
Pääjoukko
Geometria
Suuri / pieni
Pentoosit
Heksoosit
Disakkaridit
Polysakkaridit
Glykosaminoglykaanit
Aminoglykosidit
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