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Miocamycin

Miocamycin
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4S,5R,6S,7R,9R,10R,11E,13E,16R)-10-(acetyloxy)-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-4-propoxy-1-oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy}-2,4-dimethyl-3-propoxyoxan-4-yl acetate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.054.418 Edit this at Wikidata
Chemical and physical data
FormulaC45H71NO17
Molar mass898.053 g·mol−1
3D model (JSmol)
Melting point220 °C (428 °F)
Solubility in waterSlightly soluble in water; Soluble in methanol, acetone and chloroform. mg/mL (20 °C)
  • CC(=O)O[C@H]3/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]1C[C@@](C)(OC(C)=O)[C@@H](OC(=O)CC)[C@H](C)O1)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]3C
  • InChI=1S/C45H71NO17/c1-13-34(50)59-33-23-36(52)55-26(4)18-16-15-17-19-32(58-29(7)48)25(3)22-31(20-21-47)41(42(33)54-12)62-44-39(53)38(46(10)11)40(27(5)57-44)61-37-24-45(9,63-30(8)49)43(28(6)56-37)60-35(51)14-2/h15-17,19,21,25-28,31-33,37-44,53H,13-14,18,20,22-24H2,1-12H3/b16-15+,19-17+/t25-,26-,27-,28+,31+,32+,33-,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1 checkY
  • Key:GQNZGCARKRHPOH-RQIKCTSVSA-N checkY
  (verify)

Miocamycin is a macrolide antibiotic.[1] It has a spectrum activity similar to that of Erythromycin, but shows higher antimicrobial effect against certain bacteria including Legionella pneumophila (the causative agent of Legionnaires' Disease), Mycoplasma hominis, and Ureaplasma urealyticum.[1] In-vivo studies have further expounded on Miocamycin's efficacy, reporting that the medication is more effective than in-vitro data suggests.[2]

References

  1. ^ a b Holliday SM, Faulds D (October 1993). "Miocamycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential". Drugs. 46 (4): 720–45. doi:10.2165/00003495-199346040-00008. PMID 7506653. S2CID 195692285.
  2. ^ Lyseng-Williamson, Katherine A (June 2006). "Miocamycin is an effective option in the treatment of various bacterial infections". Drugs & Therapy Perspectives. 22 (6): 1–6. doi:10.2165/00042310-200622060-00001. ISSN 1172-0360. S2CID 72178165.


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