Genus of bacteria
Micromonospora is a genus of bacteria of the family Micromonosporaceae . The genus name was first proposed in 1923 by Danish physician Jeppe Ørskov in an attempt to classify what at the time was considered "ray fungi" based on morphology.[ 1] Members of this genus are found throughout natural soil and sediment environments, as well as in association with roots of plants of various species.[ 2] The genus is well known for its ability to produce a variety of medically relevant products.
They are gram-positive , spore -forming, generally aerobic , and form a branched mycelium ; they occur as saprotrophic forms in soil and water. Various species are sources of aminoglycoside antibiotics with spellings that end with -micin , such as gentamicin ,[ 3] mutamicin ,[ 4] netilmicin , retymicin , sisomicin ,[ 5] [ 6] verdamicin , calicheamicin , and the recently found turbinmicin .[ 7] Potent new antifungal drugs discovered in the microbiome of marine animals, unlike most other aminoglycoside names that end with -mycin (e.g. neomycin and streptomycin and are produced by Streptomyces spp. ).
Species
Micromonospora comprises the following species:[ 8]
References
^ Ørskov, J. (1923). Investigations Into the Morphology of the Ray Fungi . Levin & Munksgaard.
^ Hirsch, Ann M.; Valdés, Maria (2010-04-01). "Micromonospora: An important microbe for biomedicine and potentially for biocontrol and biofuels" . Soil Biology and Biochemistry . 42 (4): 536–542. doi :10.1016/j.soilbio.2009.11.023 . ISSN 0038-0717 .
^ Weinstein MJ, Luedemann GM, Oden EM, Wagman GH, Rosselet JP, Marquez JA, et al. (July 1963). "Gentamicin, a new antibiotic complex from Micromonospora". Journal of Medicinal Chemistry . 6 (4): 463–4. doi :10.1021/jm00340a034 . PMID 14184912 .
^ Testa RT, Wagman GH, Daniels PJ, Weinstein MJ (September 17, 1974). "Mutamicins; biosynthetically created new sisomicin analogues" . The Journal of Antibiotics . 27 (12): 917–21. doi :10.7164/antibiotics.27.917 . PMID 4468277 .
^ Weinstein MJ, Marquez JA, Testa RT, Wagman GH, Oden EM, Waitz JA (October 3, 1970). "Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic" . The Journal of Antibiotics . 23 (11): 551–4. doi :10.7164/antibiotics.23.551 . PMID 5487129 .
^ Christine CC, Sanders E (1973). "Sisomicin: Evaluation in vitro and Comparison with Gentamicin and Tobramycin" . Antimicrob. Agents Chemother . 3 (1): 24–8. doi :10.1128/aac.3.1.24 . PMC 444355 . PMID 4790572 .
^ Fan Zhang et al. : A marine microbiome antifungal targets urgent-threat drug-resistant fungi . In: Science Vol. 370, Issue 6519, 20 Nov 2020, pp. 974-978. doi:10.1126/science.abd6919 . See also:
^ Parte, A.C. "Micromonospora" . LPSN .