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Alimemazine
Clinical data
Other names	trimeprazine, trimeprazine (BAN UK), trimeprazine (USAN US)
AHFS/Drugs.com	International Drug Names
License data	US DailyMed: Trimeprazine;
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth
Drug class	Anti-allergic agent
ATC code	R06AD01 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	4.78 ± 0.59 hours
Identifiers
	IUPAC name N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine;
CAS Number	84-96-8 ;
PubChem CID	5574;
IUPHAR/BPS	7237;
DrugBank	DB01246 ;
ChemSpider	5373 ;
UNII	76H78MJJ52; 362NW1LD6Z;
KEGG	D07125 ; D02245;
ChEMBL	ChEMBL829 ;
CompTox Dashboard (EPA)	DTXSID9023708 ;
ECHA InfoCard	100.001.434
Chemical and physical data
Formula	C18H22N2S
Molar mass	298.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES S2c1ccccc1N(c3c2cccc3)CC(C)CN(C)C;
	InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3 ; Key:ZZHLYYDVIOPZBE-UHFFFAOYSA-N ;
	(verify)

Alimemazine (INN), also known as trimeprazine, commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine).^[3] It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic.^[4] In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses.^[5]

Alimemazine is not approved for use in humans in the United States. The combination of alimemazine and prednisolone (commonly sold under the brand name Temaril-P) is licensed as an antipruritic and antitussive in dogs.^[6] A generic version of the combination trimeprazine/prednisolone was approved by the US Food and Drug Administration (FDA) in June 2024.^[7]^[8]

Society and culture

Brand names

Brand names include Nedeltran, Panectyl, Repeltin, Teraligen, Therafene, Theraligene, Theralen, Thegalin, Theralene, Vallergan, Vanectyl, and Temaril.