RJR-2429

RJR-2429
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H16N2
Molar mass188.274 g·mol−1
3D model (JSmol)
  • C1(C2N(CC3)CCC3C2)=CN=CC=C1
  • InChI=1S/C12H16N2/c1-2-11(9-13-5-1)12-8-10-3-6-14(12)7-4-10/h1-2,5,9-10,12H,3-4,6-8H2
  • Key:YJYPZLAZNIGNRP-UHFFFAOYSA-N

RJR-2429 is a drug that acts as an agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. RJR-2429 is stronger than nicotine but weaker than epibatidine in most assays, and with high affinity for both α3β4 and α4β2 subtypes, as well as the less studied α1βγδ subtype.[1][2][3]

References

  1. ^ Bencherif M, Schmitt JD, Bhatti BS, Crooks P, Caldwell WS, Lovette ME, et al. (March 1998). "The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors". The Journal of Pharmacology and Experimental Therapeutics. 284 (3): 886–94. PMID 9495846.
  2. ^ Yokotani K, Okada S, Nakamura K (June 2002). "Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from the isolated rat adrenal gland". European Journal of Pharmacology. 446 (1–3): 83–7. doi:10.1016/s0014-2999(02)01819-8. PMID 12098588.
  3. ^ Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, et al. (May 2008). "Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands". The Journal of Organic Chemistry. 73 (9): 3497–507. doi:10.1021/jo800028q. PMID 18363376.
Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

Read other articles:

Pasquale Brignoli

Pasquale Brignoli intorno al 1860 Pasquale Brignoli, più noto come Pasquilino Brignoli[1], (Napoli, 1824 – New York, 30 ottobre 1884), è stato un tenore italiano naturalizzato statunitense. Indice 1 Biografia 2 Carriera statunitense 3 Note 4 Altri progetti 5 Collegamenti esterni Biografia Figlio di un guantaio,[1] ricevette una buona educazione musicale e divenne un pianista di discreto valore. Si dice che all'età di quindici anni compose un'opera, e, disgustato per il mo...

 

ماوروخوري

ماوروخوري   تقسيم إداري البلد اليونان  [1] خصائص جغرافية إحداثيات 40°30′41″N 21°19′15″E / 40.511388888889°N 21.320833333333°E / 40.511388888889; 21.320833333333   الارتفاع 620 متر  السكان التعداد السكاني 1287 (إحصاء السكان) (2011)1270 (resident population of Greece) (2021)1408 (resident population of Greece) (2001)1376 (resident populati...

 

Hunningham

Village and civil parish in Warwickshire, England Church of St. Margaret Hunningham is a small village and civil parish in Warwickshire, England. It is 3 miles to the north-east of Leamington Spa, within the Radford Semele ward. In 2005 the village population was 198. Hunningham village is part of the Manor of Hunningham. The history of the Manor of Hunningham is of great interest because it has been documented continuously for a thousand years, from the time of the Domesday Book, written in ...

Jambusagaranagara

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Oktober 2022. Jambusāgaranagara[1] (juga ditulis sebagai Jambūsāronagara[2]) adalah sebuah tempat atau wilayah di India di mana sebuah perguruan astronomi dan matematikawan berkembang selama abad kelima belas hingga kedelapan belas Masehi. Lokasi ...

 

Charles Roven

Charles RovenRoven pada 2010Lahir2 Agustus 1949 (umur 74)PekerjaanProduser filmSuami/istriDawn Steel (1985–97; kematiannya)Stephanie Haymes Charles Roven (lahir 2 Agustus 1949)[1] adalah seorang produser film Amerika Serikat dan presiden dan salah satu pendiri Atlas Entertainment. Ia dikenal karena memproduksi film-film pahlawan super The Dark Knight Trilogy, Suicide Squad, Man of Steel, Batman v Superman: Dawn of Justice dan more.[2] Referensi ^ Biographical Summaries...

 

Turin

Si ce bandeau n'est plus pertinent, retirez-le. Cliquez ici pour en savoir plus. Cet article ne cite pas suffisamment ses sources (mars 2014). Si vous disposez d'ouvrages ou d'articles de référence ou si vous connaissez des sites web de qualité traitant du thème abordé ici, merci de compléter l'article en donnant les références utiles à sa vérifiabilité et en les liant à la section « Notes et références ». En pratique : Quelles sources sont attendues ? Comm...

Wurdi Youang

Aboriginal stone arrangement in Victoria, Australia A small part of the Wurdi Youang stone arrangement A survey of the arrangement showing the solar alignments contained within Wurdi Youang is the name attributed to an Aboriginal stone arrangement located off the Little River – Ripley Road at Mount Rothwell, near Little River, Victoria in Australia.[1] The site was acquired by the Indigenous Land Corporation on 14 January 2000 and transferred to the Wathaurong Aboriginal Co-operativ...

 

Ossezia Settentrionale-Alania

Repubblica dell'Ossezia Settentrionale-AlaniaRepubblica(RU) Республика Северная Осетия-Алания(OS) Цæгат Ирыстоны Аланийы Республикæ (dettagli) (dettagli) LocalizzazioneStato Russia Circondario federaleCircondario federale del Caucaso Settentrionale AmministrazioneCapoluogoVladikavkaz GovernatoreSergej Menjajlo Primo ministroAlan Georgiyevich Boradzov Lingue ufficialirusso, osseto Data di istituzione7 luglio 1924 TerritorioCoordi...

 

Магаданская и Синегорская епархия

Магаданская и Синегорская епархия Троицкий собор в Магадане Страна  Россия Церковь Русская православная церковь Дата основания 31 января 1991 года Управление Главный город Магадан Кафедральный собор Троицкий Иерарх Архиепископ Магаданский и Синегорский Иоанн (Павлих�...

卡洛斯·梅内姆

此條目需要擴充。 (2015年11月27日)请協助改善这篇條目，更進一步的信息可能會在討論頁或扩充请求中找到。请在擴充條目後將此模板移除。 卡洛斯·梅内姆阿根廷總統府官方照片第47任阿根廷總統任期1989年7月8日—1999年12月10日副总统爱德华多·杜阿尔德卡洛斯·鲁考夫（英语：Carlos Ruckauf）前任劳尔·阿方辛 个人资料出生(1930-07-02)1930年7月2日 阿根廷拉里奥哈省阿尼利亚�...

 

Mexico women's national water polo team

Mexican national sports team MexicoFINA codeMEXConfederationUANA (Americas) The Mexico women's national water polo team is the representative for Mexico in international women's water polo. References vte National sports teams of Mexico Sport in Mexico A1 GP Acceleration American football M W Badminton Baseball U18 Baseball5 Basketball M M U18 M U17 M 3x3 W W U19 W U17 W 3x3 Beach soccer Beach handball Cricket M W Field hockey M W Football M M U23 M U21 M U20 M U18 M U17 M U15 M CP W W U20 W ...

 

Everett, Washington

City in Washington, United StatesEverett dᶻəɬigʷədCityEverett Station and the city skyline SealLogoLocation of Everett, WashingtonEverettLocation within WashingtonShow map of Washington (state)EverettLocation within the United StatesShow map of the United StatesCoordinates: 47°58′45″N 122°12′06″W / 47.97917°N 122.20167°W / 47.97917; -122.20167CountryUnited StatesStateWashingtonCountySnohomishEstablished1890IncorporatedMay 4, 1893Government •&#...

Buck Henry

Buck HenryHenry pada tahun 1978LahirHenry Zuckerman(1930-12-09)9 Desember 1930Kota New York, Amerika SerikatMeninggal8 Januari 2020(2020-01-08) (umur 89)Los Angeles, California, Amerika SerikatPendidikanPerguruan Tinggi DartmouthPekerjaanPenulis skenario, aktor, sutradara, pelawak, produserTahun aktif1961–2015Suami/istriSally ZuckermanIrene Ramp[1]Orang tuaPaul Steinberg Zuckerman (ayah)Ruth Taylor (ibu) Buck Henry (nama lahir Henry Zuckerman;[1] 9 Desember 1930&#...

 

Piala Interkontinental 1996

Piala Interkontinental 1996 Juventus River Plate 1 0 Tanggal26 November 1996StadionStadion Olimpiade Tokyo, TokyoPemain Terbaik Alessandro Del Piero (Juventus)WasitMárcio Rezende de Freitas (Brasil)Penonton48,305← 1995 1997 → Piala Interkontinental 1996 adalah sebuah pertandingan sepak bola pada 26 November 1996 antara Juventus dari Italia, juara Liga Champions UEFA 1995-96 melawan River Plate dari Argentina, juara Copa Libertadores 1996. Laga dimainkan di Stadion Olimpiade Tokyo...

 

Leo von Caprivi

Questa voce o sezione sull'argomento politici tedeschi non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Segui i suggerimenti del progetto di riferimento. Leo von Caprivi Cancelliere del ReichDurata mandato20 marzo 1890 –26 ottobre 1894 MonarcaGuglielmo II PredecessoreOtto von Bismarck SuccessoreChlodwig zu Hohenlohe-Schillingsfürst Minist...

Planar lamina

Mathematical model of a thin, flat object This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Planar lamina – news · newspapers · books · scholar · JSTOR (Octo...

 

1st of tha Month

1995 single by Bone Thugs-n-Harmony This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: 1st of tha Month – news · newspapers · books · scholar · JSTOR (May 2007) (Learn how and when to remove this message) 1st of tha MonthSingle by Bone Thugs-n-Harmonyfrom the album E. 1999 Eternal B-sideDie Die DieReleasedAugus...

 

Violin Concerto No. 3 (Saint-Saëns)

Violin Concertoby Camille Saint-SaënsKeyB minorOpus61PeriodRomanticGenreConcertoComposed1880 (1880)Movements3ScoringViolin & OrchestraPremiereDateOctober 15, 1880 (1880-10-15)LocationHamburgConductorAdolf Georg BeerPerformersPablo de Sarasate, Philharmonisches Orchester Hamburg The Violin Concerto No. 3 in B minor, Op. 61, by Camille Saint-Saëns is a piece for violin and orchestra written in March 1880. Saint-Saëns dedicated the concerto to fellow composer-virtuoso ...

A.C. Milan Primavera

Milan PrimaveraNama lengkapAssociazione Calcio Milan PrimaveraJulukani Rossoneri (Merah hitam)il Diavolo (Setan)Berdiri1962StadionVismara Sports Centre, Milan[1](Kapasitas: 1,200[2])PemilikSilvio Berlusconi[3]Presiden kehormatanSilvio Berlusconi[4]Pelatih kepalaCristian BrocchiLigaKejuaraan Nasional Primavera2012–13Semi-final[5] Kostum kandang Kostum tandang Kostum ketiga Associazione Calcio Milan Primavera adalah tim U-19 dari tim sepak bola profesio...

 

Gliese 581

Gliese 581 Ukuran Matahari (kiri) dan Gliese 581 (kanan). Data pengamatan Epos J2000.0      Ekuinoks J2000.0 Rasi bintang Libra[1] Asensio rekta  15j 19m 26.8269d[2] Deklinasi  −07° 43′ 20.189″[2] Magnitudo tampak (V) 10.56 to 10.58[note 1] Ciri-ciri Kelas spektrum M3V[5] Indeks warna B−V 1.61[6] Jenis variabel BY Dra[7][note 2 ...