Ranitidine

Ranitidine
Clinical data
Trade namesZantac,[1] others
Other namesDimethyl [(5-{[(2-{[1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine, ranitidine hydrochloride (JAN JP)
AHFS/Drugs.comMonograph
MedlinePlusa601106
License data
Pregnancy
category
Routes of
administration		By mouth, intravenous (IV)
Drug classHistamine H2 receptor antagonist, aka H2 blocker[1]
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability50% (by mouth)[12]
Protein binding15%
MetabolismLiver: FMOs, including FMO3; other enzymes
Onset of action55–65 minutes (150 mg dose)[13]
55–115 minutes (75 mg dose)[13]
Elimination half-life2–3 hours
Excretion30–70% kidney
Identifiers
  • N-(2-[(5-[(Dimethylamino)methyl]furan-2-yl)methylthio]ethyl)-N'-methyl-2-nitroethene-1,1-diamine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.060.283 Edit this at Wikidata
Chemical and physical data
FormulaC13H22N4O3S
Molar mass314.40 g·mol−1
3D model (JSmol)
  • CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C
  • InChI=1S/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3 ☒N
  • Key:VMXUWOKSQNHOCA-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Ranitidine, previously sold under the brand name Zantac[a] among others, is a medication used to decrease stomach acid production.[12] It was commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome.[12] It can be given by mouth, injection into a muscle, or injection into a vein.

In September 2019, the probable carcinogen N-nitrosodimethylamine (NDMA) was discovered in ranitidine products from a number of manufacturers, resulting in recalls.[14][15][16][17] In April 2020, ranitidine was withdrawn from the United States market and suspended in the European Union and Australia due to these concerns.[18][19][20][11][21][22]

In 2022, these concerns were confirmed in a Taiwanese nationwide population study finding "significant trends of increased liver cancer risk with an increasing dose of ranitidine" (up to 22% higher than control) and increased gastric, pancreatic, lung[b] and overall[c] cancer risk.[23]

Common side effects include headaches, and pain or burning sensation if given by injection.[12] Serious side effects may include cancer,[24] liver problems, a slow heart rate, pneumonia, and the potential of masking stomach cancer.[12] It is also linked to an increased risk of Clostridioides difficile colitis.[25] Ranitidine is an H2 histamine receptor antagonist that works by blocking histamine, thus decreasing the amount of acid released by cells of the stomach.[12]

Ranitidine was discovered in England in 1976 and came into commercial use in 1981.[26] It is on the World Health Organization's List of Essential Medicines.[27][28][29] It has been withdrawn at regulator request from most markets, including the United States;[12] according to the UK NHS, it has been discontinued globally.[30]

Former medical uses

  • Relief of heartburn[1]
  • Short-term and maintenance therapy of gastric and duodenal ulcers[1]
  • With nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce the risk of ulceration[1] Proton-pump inhibitors (PPIs) are more effective for the prevention of NSAID-induced ulcers.[31]
  • Pathologic gastrointestinal (GI) hypersecretory conditions such as Zollinger–Ellison syndrome
  • Gastroesophageal reflux disease (GORD or GERD)
  • Erosive esophagitis
  • Part of a multidrug regimen for H. pylori eradication to minimise the risk of duodenal ulcer recurrence
  • Recurrent postoperative ulcer
  • Upper GI bleeding
  • For prevention of acid-aspiration pneumonitis during surgery, it can be administered preoperatively. The drug increases gastric pH, but generally has no effect on gastric volume. In a 2009 meta-analysis comparing the net benefit of PPIs and ranitidine to reduce the risk of aspiration before anaesthesia, ranitidine was found to be more effective than PPIs in reducing the volume of gastric secretions.[32] Ranitidine may have an anti-emetic effect when administered preoperatively.
  • Prevention of stress-induced ulcers in critically ill patients[33]
  • Used together with diphenhydramine as secondary treatment for anaphylaxis; after first-line epinephrine.[34][35]

Contraindication

Ranitidine has been discontinued globally, according to the NHS,[30] and is contraindicated due to excess cancer risk and the ready availability of H2 antagonist and PPI alternatives.

Adverse effects

These adverse effects for ranitidine have been reported as events in clinical trials:

Central nervous system

Rare reports have been made of ranitidine causing malaise, dizziness, somnolence, insomnia, and vertigo. In severely ill, elderly patients, cases of reversible mental confusion, agitation, depression, and hallucinations have been reported.[1]

Cardiovascular

Arrhythmias such as tachycardia, bradycardia, atrioventricular block, and premature ventricular beats have also been reported.[1]

Gastrointestinal

All drugs in the H2 receptor blocker class of medicines have the potential to cause vitamin B12 deficiency, secondary to a reduction in food-bound vitamin B12 absorption.[36] Elderly patients taking H2 receptor antagonists are more likely to require B12 supplementation than those not taking such drugs.[37] H2 blockers may also reduce the absorption of drugs (azole antifungals, calcium carbonate) that require an acidic stomach.[38] In addition, multiple studies suggest the use of H2 receptor antagonists such as ranitidine may increase the risk of infectious diarrhoea, including traveller's diarrhoea and salmonellosis.[39][40][41][42][43] A 2005 study found that by suppressing acid-mediated breakdown of proteins, ranitidine may lead to an elevated risk of developing food or drug allergies, due to undigested proteins then passing into the GI tract, where sensitisation occurs. Patients who take these agents develop higher levels of immunoglobulin E against food, whether they had prior antibodies or not.[44] Even months after discontinuation, an elevated level of IgE in 6% of patients was still found in the study.[medical citation needed]

Liver

Cholestatic hepatitis, liver failure, hepatitis, and jaundice have been noted, and require immediate discontinuation of the drug.[1] Blood tests can reveal an increase in liver enzymes or eosinophilia, although in rare instances, severe cases of hepatotoxicity may require a liver biopsy.[45]

Lungs

Ranitidine and other histamine H2 receptor antagonists may increase the risk of pneumonia in hospitalised patients.[46] Ranitidine increases the risk of community-acquired pneumonia in adults and children.[47][48]

Blood

Thrombocytopenia is a rare but known side effect. Drug-induced thrombocytopenia usually takes weeks or months to appear, but may appear within 12 hours of drug intake in a sensitised individual. Typically, the platelet count falls to 80% of normal, and thrombocytopenia may be associated with neutropenia and anemia.[49]

Skin

Rash, including rare cases of erythema multiforme, and rare cases of hair loss and vasculitis have been seen.[1]

Precautions

Relief of symptoms due to the use of ranitidine does not exclude the presence of a gastric malignancy. In addition, with kidney or liver impairment, ranitidine must be used with caution. It should be avoided in patients with porphyria, as it may precipitate an attack.[50][51]

Children

In children, the use of gastric acid inhibitors has been associated with an increased risk for development of acute gastroenteritis and community-acquired pneumonia.[47] A cohort analysis including over 11,000 neonates reported an association of H2 blocker use, and an increased incidence of necrotizing enterocolitis in very-low-birth-weight (VLBW) neonates.[52] In addition, about a six-fold increase in mortality, necrotizing enterocolitis, and infection such as sepsis, pneumonia, urinary tract infection was reported in patients receiving ranitidine in a cohort analysis of 274 VLBW neonates.[53]

Drug tests

Ranitidine may return a false positive result with some commercial urine drug screening kits for testing for drugs of abuse.[54]

Cancer-causing due to inherent instability

See also: Valsartan § recalls, and Angiotensin II receptor blocker § recalls

In June 2019, Valisure informed the US Food and Drug Administration (FDA) that Zantac-branded and generic ranitidine resulted in very high levels of NDMA in the human body "due to an inherent instability of the ranitidine molecule".[55][56]

In September 2019, the FDA acknowledged that ranitidine medicines, including some products sold under the brand name Zantac, contained a nitrosamine impurity called N-nitrosodimethylamine (NDMA), classified as a probable human carcinogen, at unacceptable levels.[15][18][57] Health Canada announced that it was assessing NDMA in ranitidine[14] and requested that manufacturers stop the distribution of ranitidine products in Canada until the NDMA levels in the products are found to be safe.[58] Health Canada announced that ranitidine drugs were being recalled by Sandoz Canada, Apotex Inc., Pro Doc Limitée, Sanis Health Inc., and Sivem Pharmaceuticals ULC.[58] The European Medicines Agency (EMA) started a European Union-wide review of ranitidine medicines at the request of the European Commission.[16][59]

In October 2019, the US. FDA observed that the third-party laboratory that found very high levels of NDMA was using higher temperatures in its tests to detect nitrosamine impurities. The NDMA was mostly generated by the added heat, but the higher temperatures are recommended for using a gas chromatography–mass spectrometry method to test for NDMA in valsartan and angiotensin II receptor blockers.[60] The FDA stated that it recommends using a Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) testing protocol to test samples of ranitidine.[61] Its LC-HRMS testing method does not use elevated temperatures, and has shown the presence of much lower levels of NDMA in ranitidine medicines than were reported by the third-party laboratory. International regulators using similar LC-MS testing methods have also shown the presence of lower but still unacceptable levels of NDMA in ranitidine samples.[17] The FDA provided additional guidance about using another LC-MS method based on a triple-quadrupole MS platform.[17][62]

In September 2019, Sandoz issued a "precautionary distribution stop" of all medicines containing ranitidine,[63][64] followed a few days later by a recall of ranitidine hydrochloride capsules in the United States.[65][66][67] The Italian Medicines Agency recalled all ranitidine that uses an active pharmaceutical ingredient from Saraca Laboratories.[68][69][70] The Federal Union of German Associations of Pharmacists (Arzneimittelkommission der Deutschen Apotheker) published a list of recalled products,[71] as did the Therapeutic Goods Administration in Australia.[72]

In November 2019, the FDA stated that its tests found levels of NDMA in ranitidine and nizatidine that are similar to those that one may typically ingest with common foods such as grilled or smoked meats.[73][74] The FDA also stated that its simulated gastric fluid model tests and simulated intestinal fluid model tests indicated that NDMA is not formed when exposed to acid in the stomach with a normal diet.[73][74] The FDA advised companies to recall their ranitidine if testing shows levels of NDMA above the acceptable daily intake (96 nanograms per day or 0.32 parts per million for ranitidine).[17] At the same time, it indicated that some levels of NDMA found in medicines still exceeded the agency's acceptable levels.[73][74]

In December 2019, the FDA asked manufacturers of ranitidine and nizatidine products to expand their NDMA testing to include all lots of the medication before making them available to consumers.[75]

By the end of 2019, ranitidine had already fallen from the 40th most commonly prescribed medication in the United States in 2018, to 53rd place for 2019, with about 13.6 million prescriptions for the year, versus nearly 19 million the previous year.[76] This reflects total prescriptions for all of 2019, while safety concerns affected sales in only the final 4 months of the year.

In April 2020, new FDA testing and evaluation prompted by information from third-party laboratories confirmed that NDMA levels increase in ranitidine even under normal storage conditions, and NDMA has been found to increase significantly in samples stored at higher temperatures, including those at which the product may be exposed during distribution and handling by consumers.[19] The testing also showed that the level of NDMA increases as ranitidine medication ages.[19] These conditions may raise the NDMA level above the acceptable daily intake limit.[19] The EMA completed and issued their EU-wide review at the end of the month and the European Commission suspended all ranitidine products in the EU.[77]

In August 2020, the EMA provided guidance to marketing authorization holders for avoiding the presence of nitrosamine impurities and asked them to review all chemical and biological human medicines for the presence of nitrosamines and to test the products at risk.[78] In September 2020, the FDA issued guidance about the control of nitrosamine impurities in human drugs.[79][80][81] An implementation plan was issued in February 2021.[82]

In 2022, these concerns were confirmed in a Taiwanese nationwide population study finding "significant trends of increased liver cancer risk with an increasing dose of ranitidine" (22% higher than control) and increased gastric, pancreatic, lung (26%, 35%, and 17% respectively), but "only liver cancer displayed a significant association with long-term ranitidine use" and "there was no continuous dose–response relationship among the other individual cancers".[23] Overall cancer risk also increased by 10% (p < 0.001).[23]

The FDA issued revised guidelines about nitrosamine impurities in September 2024.[83]

List of recalls

In September 2019, Apotex recalled all over-the-counter ranitidine tablets sold in the United States at Walmart, Rite Aid, and Walgreens.[84][85] These retailers, along with CVS, removed Zantac and some generics from their shelves.[86][87][88][89][90]

In October 2019, the Medicines and Healthcare products Regulatory Agency of the United Kingdom (UK) issued a drug alert for ranitidine "... to proactively communicate the recall to hospitals, pharmacies, dispensing practices, retailers and wholesalers in the UK."[91] This included all Zantac-branded preparations,[92][93] along with all generic preparations of ranitidine from Teva UK Limited,[94][95] Rosemont Pharmaceuticals Limited,[96] Omega Pharma Limited and Galpharm International Limited,[97] Perrigo Company plc,[98] Creo Pharma Limited and Tillomed Laboratories Limited,[99][100] OTC Concepts Ltd, Relonchem Ltd, Noumed Life Sciences Ltd, and Medreich Plc.,[101][102] Accord Healthcare,[103] Medley Pharma Limited,[104] and Medreich Plc.[105]

In October 2019, the Department of Health and Social Care of the United Kingdom issued a supply distribution alert (SDA/2019/005) for all oral formulations of ranitidine.[106]

In October 2019, Sanofi recalled all over-the-counter Zantac in the United States and Canada,[107][108][17] Perrigo issued a worldwide recall of ranitidine,[109][17] Dr. Reddy's issued a recall of all ranitidine products in the United States,[110][17] and Novitium Pharma recalled all ranitidine hydrochloride capsules in the US.[111][17]

In November 2019, Aurobindo Pharma, Amneal Pharmaceuticals, American Health Packaging, Golden State Medical Supply, and Precision Dose recalled some lots of ranitidine tablets, capsules, and syrup.[112][113][114][115][116]

In December 2019, Glenmark Pharmaceutical Inc., USA, recalled some lots of ranitidine tablets.[117]

In January 2020, Appco Pharma LLC and Northwind Pharmaceuticals recalled some lots of ranitidine tablets and capsules.[118][119]

In February 2020, American Health Packaging recalled some lots of ranitidine tablets manufactured by Amneal Pharmaceuticals.[120]

In April 2020, the FDA requested a manufacturer's market withdrawal of ranitidine,[19][121] meaning that ranitidine products would not be available for prescription or over-the-counter sale in the US.[18][19]

In April 2020, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency recommended the suspension of all ranitidine medicines in the European Union because of the presence of unacceptable levels of NDMA.[122][11][20]

A ranitidine manufacturer requested a re-examination of the decision,[11] but in December 2020, the EMA confirmed its recommendation to suspend all ranitidine medicines in the European Union.[11] The UK National Health Service (NHS) Web site as of December 2021 said "Ranitidine is not currently available in the UK or globally... It's not yet known whether it will be available again in future." A March 2024 review left the message up.[123]

In 2021, Solara Active Pharma Sciences, which supplies ranitidine active pharmaceutical ingredient (API), said that it had mitigated the risks of the formation of NDMA during the manufacturing of ranitidine API. The company was granted a revised certificate by the European Directorate for the Quality of Medicines and Healthcare, which proves that the API complies with certain European rules.[124] GlaxoSmithKline, Sanofi, and Teva said they had no plans to reintroduce the drug in the EU, but Accord Healthcare considered the possible reintroduction of ranitidine.[124] However a control strategy regarding NDMA formation through the end of the product’s shelf life, despite heat, time and digestion due to endogenous formation from the API, would be required.[124]

Pharmacology

Mechanism of action

Ranitidine is a competitive, reversible inhibitor of the action of histamine at the histamine H2 receptors found in gastric parietal cells. This results in decreased gastric acid secretion and gastric volume, and reduced hydrogen ion concentration.[125] Ranitidine's acid-lowering effect is more pronounced for basal and nocturnal acid secretion than it is for food-stimulated acid secretion. Additional indirect effects of ranitidine are decreased pepsin secretion and increased nitrate-reducing bacterial flora.[125]

Pharmacokinetics

Oral absorption: 50%[125]

Protein binding: 15%[126]

Metabolism: The major metabolite in the urine is ranitidine N-oxide, which represents less than 4% of the dose. Other metabolites of ranitidine include ranitidine S-oxide (1%) and desmethyl ranitidine (1%).[127]

Half-life elimination: With normal renal function, ranitidine taken orally has a half-life of 2.5–3.0 hours.[125] If taken intravenously, the half-life is generally 2.0–2.5 hours in a patient with normal kidney function and normal creatinine clearance.[medical citation needed] In patients with kidney dysfunction, the half-life may increase to 4 to 5 hours.[125]

Excretion: The primary route of excretion is the urine.[125] In addition, about 30% of the orally administered dose is collected in the urine as unabsorbed drug in 24 hours.[128]

Elderly

In the elderly population, the plasma half-life of ranitidine is prolonged to 3–4 hours secondary to decreased kidney function causing decreased clearance.[1]

Children

In general, studies of pediatric patients (aged one month to 16 years) have shown no significant differences in pharmacokinetic parameter values in comparison to healthy adults, when correction is made for body weight.[1]

History

Zantac 300 mg tablets from GlaxoSmithKline (GSK) as sold in Australia

Ranitidine was first prepared in England as AH19065 by John Bradshaw in the summer of 1977 in the Ware research laboratories of Allen and Hanburys, part of the former Glaxo organisation.[129][130] Its development was a response to the first in class histamine H2 receptor antagonist, cimetidine, developed by Sir James Black at Smith, Kline and French, and launched in the United Kingdom as Tagamet in November 1976. Both companies eventually merged as GlaxoSmithKline (GSK), following a sequence of mergers and acquisitions, starting with the integration of Allen and Hanbury's Ltd and Glaxo to form Glaxo Group Research in 1979, and ultimately with the merger of Glaxo Wellcome and SmithKline Beecham in 2000. Ranitidine was the result of a rational drug-design process using what was by then a fairly refined model of the histamine H2 receptor and quantitative structure-activity relationships.

Glaxo refined the model further, by replacing the imidazole ring of cimetidine with a furan ring with a nitrogen-containing substituent, and in doing so developed ranitidine. Ranitidine was found to have a far-improved tolerability profile (i.e. fewer adverse drug reactions), longer-lasting action, and 10 times the activity of cimetidine. Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions.[131]

Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987.[132] Subsequently, it was largely superseded by the more effective proton-pump inhibitor (PPI) class of drugs, with omeprazole becoming the biggest-selling drug for many years.[citation needed] When omeprazole and ranitidine were compared in a study of 144 people with severe inflammation and erosions or ulcers of the oesophagus, 85% of those treated with omeprazole healed within eight weeks, compared with 50% of those given ranitidine. In addition, the omeprazole group reported earlier relief of heartburn symptoms.[133][134]

In September 2019, the probable carcinogen N-nitrosodimethylamine (NDMA) was discovered in ranitidine products from a number of manufacturers, resulting in recalls; in April 2020, it was withdrawn from the United States market and suspended in Europe and Australia.

Preparations

Preparations of ranitidine products include oral tablets (75, 150, and 300 mg), effervescent tablets, and syrups,[1] and injectable solutions;[91] with doses of specific ranitidine product preparations are available over-the-counter (OTC) in various countries. In the United Kingdom, only the lowest-strength, 75-mg tablet was available to purchase without a prescription.[1] In Australia, packs containing seven or 14 doses of the 150-mg tablet were available in supermarkets, small packs of 150-mg and 300-mg tablets were schedule 2 pharmacy medicines.[medical citation needed] Larger doses and pack sizes required a prescription.[medical citation needed] In the United States, 75- and 150-mg tablets were available OTC.[135][136] In India, it is sold under multiple brand names.[48]

References

  1. ^ a b c d e f g h i j k l m n "Zantac 150 (ranitidine hydrochloride) Tablets, USP Zantac 300 (ranitidine hydrochloride) Tablets, USP". DailyMed. 28 June 2018. Archived from the original on 4 July 2022. Retrieved 18 February 2021.
  2. ^ "Ranitidine use during pregnancy". Drugs.com. 2 December 2019. Archived from the original on 29 October 2019. Retrieved 18 December 2019.
  3. ^ "Nitrosamine impurities in medications: Medications affected". Health Canada. 19 March 2021. Retrieved 7 January 2024.
  4. ^ "Acid Reducer (Ranitidine) Tablet: N-nitrosodimethylamine (NDMA) impurity". Health Canada. 6 December 2021. Retrieved 7 January 2024.
  5. ^ https://pdf.hres.ca/dpd_pm/00003505.PDF [bare URL PDF]
  6. ^ "Ranitidine 50mg/2ml Solution for Injection and Infusion". medicines.org.uk. 13 October 2021. Retrieved 7 January 2024.
  7. ^ "Boots Heartburn & Indigestion Relief 75mg Tablets (P)". medicines.org.uk. 3 October 2016. Retrieved 7 January 2024.
  8. ^ "Boots Heartburn & Indigestion Relief 75mg Tablets". medicines.org.uk. 3 October 2016. Retrieved 7 January 2024.
  9. ^ "Zantac 150". DailyMed. 3 April 2018. Archived from the original on 4 July 2022. Retrieved 18 February 2021.
  10. ^ "Ranitidine hydrochloride capsule". DailyMed. 21 November 2018. Retrieved 7 January 2024.
  11. ^ a b c d e "Ranitidine-containing medicinal products". European Medicines Agency (EMA). 30 April 2020. Archived from the original on 6 May 2020. Retrieved 6 May 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  12. ^ a b c d e f g "Ranitidine hydrochloride monograph". The American Society of Health-System Pharmacists. Archived from the original on 9 September 2017. Retrieved 1 December 2015.
  13. ^ a b Gardner JD, Ciociola AA, Robinson M, McIsaac RL (July 2002). "Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity". Alimentary Pharmacology & Therapeutics. 16 (7): 1317–1326. doi:10.1046/j.1365-2036.2002.01291.x. PMID 12144582. S2CID 34396030.
  14. ^ a b "Health Canada assessing NDMA in ranitidine". Health Canada. 13 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019.
  15. ^ a b "Statement alerting patients and health care professionals of NDMA found in samples of ranitidine". U.S. Food and Drug Administration (FDA). 13 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  16. ^ a b "EMA to provide guidance on avoiding nitrosamines in human medicines". European Medicines Agency (Press release). 13 September 2019. Archived from the original on 31 December 2019. Retrieved 19 September 2019.
  17. ^ a b c d e f g h "FDA updates and press announcements on NDMA in Zantac (ranitidine)". U.S. Food and Drug Administration (FDA). 28 October 2019. Archived from the original on 29 October 2019. Retrieved 28 October 2019. FDA observed the testing method used by a third-party laboratory uses higher temperatures. The higher temperatures generated very high levels of NDMA from ranitidine products because of the test procedure. The FDA published the method for testing angiotensin II receptor blockers (ARBs) for nitrosamine impurities. That method is not suitable for testing ranitidine because heating the sample generates NDMA.
    FDA recommends using an LC-HRMS testing protocol to test samples of ranitidine. FDA's LC-HRMS testing method does not use elevated temperatures and has shown the presence of much lower levels of NDMA in ranitidine medicines than reported by the third-party laboratory. International regulators using similar LC-MS testing methods have also shown the presence of low levels of NDMA in ranitidine samples.     Public Domain This article incorporates text from this source, which is in the public domain.
  18. ^ a b c "Questions and Answers: NDMA impurities in ranitidine (commonly known as Zantac)". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  19. ^ a b c d e f "FDA Requests Removal of All Ranitidine Products (Zantac) from the Market". U.S. Food and Drug Administration (FDA) (Press release). 1 April 2020. Archived from the original on 28 March 2021. Retrieved 1 April 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  20. ^ a b "Suspension of ranitidine medicines in the EU". European Medicines Agency (Press release). 30 April 2020. Archived from the original on 5 January 2021. Retrieved 2 June 2020.
  21. ^ "Ranitidine". Therapeutic Goods Administration (TGA). 2 April 2020. Archived from the original on 29 August 2021. Retrieved 19 July 2020.
  22. ^ Wagner JA, Dinh JC, Lightdale JR, Gold BD, Colombo JM (July 2021). "Is this the end for ranitidine? NDMA presence continues to confound". Clinical and Translational Science. 14 (4): 1197–1200. doi:10.1111/cts.12995. PMC 8301580. PMID 33934515.
  23. ^ a b c d e Wang CH, Chen II, Chen CH, Tseng YT (September 2022). "Pharmacoepidemiological Research on N-Nitrosodimethylamine-Contaminated Ranitidine Use and Long-Term Cancer Risk: A Population-Based Longitudinal Cohort Study". International Journal of Environmental Research and Public Health. 19 (19): 12469. doi:10.3390/ijerph191912469. PMC 9566239. PMID 36231768.
  24. ^ "Zantac's Maker Kept Quiet About Cancer Risks for 40 Years". Bloomberg.com. 15 February 2023. Archived from the original on 19 February 2023. Retrieved 20 February 2023.
  25. ^ Tleyjeh IM, Abdulhak AB, Riaz M, Garbati MA, Al-Tannir M, Alasmari FA, et al. (2013). "The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis". PLOS ONE. 8 (3): e56498. Bibcode:2013PLoSO...856498T. doi:10.1371/journal.pone.0056498. PMC 3587620. PMID 23469173.
  26. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 444. ISBN 9783527607495. Archived from the original on 20 December 2016.
  27. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  28. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  29. ^ "eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 20 February 2023. Retrieved 20 February 2023.
  30. ^ a b "Ranitidine: medicine to lower stomach acid". nhs.uk. 29 August 2018. Archived from the original on 3 December 2021. Retrieved 20 February 2023.
  31. ^ "Reflux Remedies: ranitidine". PharmaSight OTC Health. Archived from the original on 12 January 2013. Retrieved 16 November 2011.
  32. ^ Clark K, Lam LT, Gibson S, Currow D (June 2009). "The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials". Anaesthesia. 64 (6): 652–657. doi:10.1111/j.1365-2044.2008.05861.x. PMID 19453319. S2CID 7799380.
  33. ^ Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. (February 2013). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012". Intensive Care Medicine. 39 (2): 165–228. doi:10.1007/s00134-012-2769-8. PMC 2249616. PMID 23361625.
  34. ^ Tang AW (October 2003). "A practical guide to anaphylaxis". American Family Physician. 68 (7): 1325–1332. PMID 14567487. Archived from the original on 10 January 2017. Retrieved 3 February 2017.
  35. ^ "Anaphylaxis: Diagnosis and Management in the Rural Emergency Department" (PDF). American Journal of Clinical Medicine. Archived (PDF) from the original on 14 August 2016. Retrieved 3 February 2017.
  36. ^ Force RW, Nahata MC (October 1992). "Effect of histamine H2-receptor antagonists on vitamin B12 absorption". The Annals of Pharmacotherapy. 26 (10): 1283–1286. doi:10.1177/106002809202601018. PMID 1358279. S2CID 35308626.
  37. ^ Mitchell SL, Rockwood K (May 2001). "The association between antiulcer medication and initiation of cobalamin replacement in older persons". Journal of Clinical Epidemiology. 54 (5): 531–534. doi:10.1016/S0895-4356(00)00340-1. PMID 11337218.
  38. ^ "Reflux Remedies: ranitidine". PharmaSight OTC Health. PharmaSight.org. Archived from the original on 21 August 2017. Retrieved 16 November 2011.
  39. ^ Cobelens FG, Leentvaar-Kuijpers A, Kleijnen J, Coutinho RA (November 1998). "Incidence and risk factors of diarrhoea in Dutch travellers: consequences for priorities in pre-travel health advice". Tropical Medicine & International Health. 3 (11): 896–903. PMID 9855403.
  40. ^ Neal KR, Briji SO, Slack RC, Hawkey CJ, Logan RF (January 1994). "Recent treatment with H2 antagonists and antibiotics and gastric surgery as risk factors for Salmonella infection". BMJ. 308 (6922): 176. doi:10.1136/bmj.308.6922.176. PMC 2542523. PMID 7906170.
  41. ^ Neal KR, Scott HM, Slack RC, Logan RF (February 1996). "Omeprazole as a risk factor for campylobacter gastroenteritis: case-control study". BMJ. 312 (7028): 414–415. doi:10.1136/bmj.312.7028.414. PMC 2350063. PMID 8601113.
  42. ^ Wickramasinghe LS, Basu SK (1984). "Salmonellosis during treatment with ranitidine". Unreviewed reports. BMJ. 289 (6454): 1272. doi:10.1136/bmj.289.6454.1272.
  43. ^ Ruddell WS, Axon AT, Findlay JM, Bartholomew BA, Hill MJ (March 1980). "Effect of cimetidine on the gastric bacterial flora". Lancet. 1 (8170): 672–674. doi:10.1016/s0140-6736(80)92826-3. PMID 6103090. S2CID 35753958.
  44. ^ Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, et al. (April 2005). "Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients". FASEB Journal. 19 (6): 656–658. doi:10.1096/fj.04-3170fje. PMID 15671152. S2CID 18832411.
  45. ^ "Ranitidine: Hepatotoxicity". U.S. National Institutes of Health (NIH). 28 June 2016. Archived from the original on 28 August 2016. Retrieved 25 August 2016.
  46. ^ Mallow S, Rebuck JA, Osler T, Ahern J, Healey MA, Rogers FB (2004). "Do proton pump inhibitors increase the incidence of nosocomial pneumonia and related infectious complications when compared with histamine-2 receptor antagonists in critically ill trauma patients?". Current Surgery. 61 (5): 452–458. doi:10.1016/j.cursur.2004.03.014. PMID 15475094.
  47. ^ a b Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, et al. (May 2006). "Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children". Pediatrics. 117 (5): e817 – e820. doi:10.1542/peds.2005-1655. PMID 16651285. S2CID 23719299.
  48. ^ a b "Rantac OD 300". Medical Dialogues. Archived from the original on 4 July 2022. Retrieved 19 January 2021.
  49. ^ Bangia AV, Kamath N, Mohan V (February 2011). "Ranitidine-induced thrombocytopenia: A rare drug reaction". Indian Journal of Pharmacology. 43 (1): 76–77. doi:10.4103/0253-7613.75676. PMC 3062128. PMID 21455428.
  50. ^ "Ranitidine drug information". Lexicomp. Archived from the original on 20 April 2014.
  51. ^ "Ranitidine - core safety profile" (PDF). Bundesinstitut für Arzneimittel und MedizinProdukte. Archived (PDF) from the original on 26 November 2020. Retrieved 29 September 2019.
  52. ^ Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, et al. (February 2006). "Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants". Pediatrics. 117 (2): e137 – e142. doi:10.1542/peds.2005-1543. PMID 16390920. S2CID 41491264.
  53. ^ Terrin G, Passariello A, De Curtis M, Manguso F, Salvia G, Lega L, et al. (January 2012). "Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns". Pediatrics. 129 (1): e40 – e45. doi:10.1542/peds.2011-0796. PMID 22157140.
  54. ^ Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA (August 2010). "Commonly prescribed medications and potential false-positive urine drug screens". American Journal of Health-System Pharmacy. 67 (16): 1344–1350. doi:10.2146/ajhp090477. PMID 20689123. S2CID 12339028.
  55. ^ "Earliest NDMA alert". www.valisure.com. Valisure discovered the link of Zantac and its generics to the carcinogen NDMA during its routine testing of every batch of every medication, and first notified the FDA of its initial findings in June of 2019
  56. ^ Valisure, (and FDA CDER). "Requests FDA to issue a regulation, revise industry guidance, and request a recall and suspend sales of ranitidine from the US market and take such other actions listed in the petition --Valisure FDA Petition, Attachments (and responses)". www.regulations.gov. Retrieved 16 May 2024. ranitidine formed millions of nanograms of NDMA [per tablet]
  57. ^ "Zantac (ranitidine): Safety Information - NDMA Found in Samples of Some Ranitidine Medicines". U.S. Food and Drug Administration (FDA). 12 September 2019. Archived from the original on 6 May 2020. Retrieved 6 May 2020.
  58. ^ a b "Health Canada requests that companies stop distributing ranitidine drugs in Canada while it assesses NDMA; additional products being recalled - Recalls and safety alerts". Health Canada. 26 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019.
  59. ^ "EMA to review ranitidine medicines following detection of NDMA". European Medicines Agency (EMA) (Press release). 13 September 2019. Archived from the original on 13 February 2020. Retrieved 19 September 2019.
  60. ^ "FDA updates and press announcements on Angiotensin II Receptor Blocker (ARB) recalls (Valsartan, Losartan, and Irbesartan)". U.S. Food and Drug Administration (FDA). 20 September 2019. Archived from the original on 3 October 2019. Retrieved 2 October 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  61. ^ "Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) method for the determination of NDMA in Ranitidine drug substance and drug product" (PDF). U.S. Food and Drug Administration (FDA). FY19-177-DP A-S. Archived from the original on 2 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  62. ^ "Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the determination of NDMA in Ranitidine drug substance and solid dosage drug product" (PDF). U.S. Food and Drug Administration (FDA). 17 October 2019. Archived from the original on 2 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  63. ^ Bomey N (19 September 2019). "Ranitidine warnings: Generic Zantac distribution halted on cancer fear". USA Today. Archived from the original on 20 September 2019. Retrieved 20 September 2019.
  64. ^ Palmer E (19 September 2019). "Novartis doesn't wait for FDA investigation and halts distribution of its generic Zantac". FiercePharma. Archived from the original on 20 September 2019. Retrieved 20 September 2019. Novartis on Wednesday said it was stopping worldwide distribution of its generic versions of the antacid while regulators investigate the fact that the impurity NDMA has been detected in these ranitidine-based drugs.
  65. ^ "Sandoz ceases distribution of ranitidine product". Pharmaceutical news, Pharma industry, Pharmaceutical manufacturing. 19 September 2019. Archived from the original on 10 January 2020. Retrieved 24 September 2019.
  66. ^ "Sandoz expands recall of antacid". Pharmaceutical news, Pharma industry, Pharmaceutical manufacturing. 24 September 2019. Archived from the original on 27 January 2020. Retrieved 24 September 2019.
  67. ^ "Sandoz Inc. issues voluntary recall of Ranitidine Hydrochloride capsules 150mg and 300mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA), in the product" (Press release). Sandoz Inc. 23 September 2019. Archived from the original on 24 September 2019. Retrieved 24 September 2019 – via PR Newswire.
  68. ^ Thomas K (19 September 2019). "Should you keep taking Zantac for your heartburn?". The New York Times. Archived from the original on 23 September 2019. Retrieved 24 September 2019.
  69. ^ "Carcinogen scare sets off global race to contain tainted Zantac". Los Angeles Times. 18 September 2019. Archived from the original on 22 September 2019. Retrieved 24 September 2019.
  70. ^ "Comunicazione AIFA sui farmaci contenenti ranitidina". Agenzia Italiana del Farmaco (in Italian). Rome, Italy. Archived from the original on 18 April 2020. Retrieved 30 March 2020.
  71. ^ "Online Nachricht: AMK: Liste der (Chargen-)Rückrufe Ranitidin-haltiger Arzneimittel". Arzneimittelkommission der Deutschen Apotheker (AMK) (in German). 17 September 2019. Archived from the original on 20 September 2019. Retrieved 20 March 2020.
  72. ^ "Ranitidine". Therapeutic Goods Administration. 17 October 2019. Archived from the original on 19 October 2019. Retrieved 19 October 2019.
  73. ^ a b c "Statement on new testing results, including low levels of impurities in ranitidine drugs". U.S. Food and Drug Administration (FDA) (Press release). 1 November 2019. Archived from the original on 2 November 2019. Retrieved 1 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  74. ^ a b c "Laboratory tests - Ranitidine". U.S. Food and Drug Administration (FDA). 1 November 2019. Archived from the original on 2 November 2019. Retrieved 1 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  75. ^ "FDA updates and press announcements on NDMA in Zantac (ranitidine)". U.S. Food and Drug Administration (FDA). 4 December 2019. Archived from the original on 6 December 2019. Retrieved 6 December 2019. Today, we are announcing that we have asked manufacturers of ranitidine and nizatidine products to expand their testing for NDMA to include all lots of the medication before making them available to consumers. If testing shows NDMA above the acceptable daily intake limit (96 nanograms per day or 0.32 parts per million for ranitidine), the manufacturer must inform the agency and should not release the lot for consumer use. Public Domain This article incorporates text from this source, which is in the public domain.
  76. ^ "Ranitidine - Drug Usage Statistics". ClinCalc. Archived from the original on 7 December 2021. Retrieved 25 March 2024.
  77. ^ EMA (30 April 2020). "Suspension of ranitidine medicines in the EU". European Medicines Agency. Archived from the original on 5 January 2021. Retrieved 27 March 2023.
  78. ^ "Nitrosamine impurities". European Medicines Agency (EMA). 6 August 2020. Archived from the original on 4 August 2020. Retrieved 6 August 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  79. ^ "FDA Provides Guidance to Industry for Detecting and Preventing Nitrosamines in Drugs". U.S. Food and Drug Administration (FDA) (Press release). 1 September 2020. Archived from the original on 1 September 2020. Retrieved 1 September 2020.
  80. ^ "Control of Nitrosamine Impurities in Human Drugs" (PDF). U.S. Food and Drug Administration (FDA). 1 September 2020. Archived from the original on 2 September 2020. Retrieved 1 September 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  81. ^ Control of Nitrosamine Impurities in Human Drugs (Report). U.S. Food and Drug Administration (FDA). September 2020. FDA-2020-D-1530. Archived from the original on 1 June 2022. Retrieved 24 June 2022. Public Domain This article incorporates text from this source, which is in the public domain.
  82. ^ European Medicines Regulatory Network approach for the implementation of the CHMP Opinion pursuant to Article 5(3) of Regulation (EC) No 726/2004 for nitrosamine impurities in human medicines (PDF) (Report). 18 February 2021. EMA/425645/2020. Archived (PDF) from the original on 4 July 2022. Retrieved 20 February 2021.
  83. ^ "Control of Nitrosamine Impurities in Human Drugs". U.S. Food and Drug Administration. 24 February 2021. Retrieved 6 September 2024.
  84. ^ "Apotex Corp. issues voluntary nationwide recall of Ranitidine tablets 75mg and 150mg (all pack sizes and formats) due to the potential for detection of an amount of unexpected impurity, N-nitrosodimethylamine (NDMA) impurity in the product". U.S. Food and Drug Administration (FDA). 26 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  85. ^ "Heartburn drug recalled, removed from shelves over cancer concerns". United Press International. 30 September 2019. Archived from the original on 1 October 2019. Retrieved 1 October 2019.
  86. ^ Garcia SE (30 September 2019). "Zantac pulled from shelves by Walgreens, Rite Aid and CVS over carcinogen fears". The New York Times. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
  87. ^ "CVS pharmacy statement regarding Zantac and other Ranitidine products". CVS Health. 3 October 2019. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
  88. ^ Kazin M (2 October 2019). "Walmart suspends sale of Zantac, other products containing ranitidine over cancer risk". Fox Business. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
  89. ^ Criss D (30 September 2019). "Walmart, CVS, Walgreens pull Zantac and similar heartburn drugs because of cancer worries". CNN. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
  90. ^ Edney A (30 September 2019). "Major U.S. drugstore chains pull Zantac amid carcinogen concern". Bloomberg. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
  91. ^ a b "Zantac recall – UK recall of Zantac (Ranitidine API), incl. Zantac Injection, Zantac Tablets, Zantac Syrup". GlaxoSmithKline UK Limited. Brentford, Middlesex, United Kingdom. October 2019. Archived from the original on 11 December 2021. Retrieved 30 March 2020.
  92. ^ "Class 2 Medicines recall: Zantac Injection 50mg/2ml, Zantac Syrup 150mg/10ml, Zantac Tablets 150mg, Zantac Tablets 300mg (EL (19)A 24)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 8 October 2019. Archived from the original on 27 December 2019. Retrieved 30 March 2020. GlaxoSmithKline, trading as Glaxo Welcome Ltd, is recalling all unexpired stock of Zantac (ranitidine hydrochloride) prescription only medicines (POM) from pharmacies.
  93. ^ "Press release – Zantac – MHRA drug alert issued as GlaxoSmithKline recalls all unexpired stock". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 8 October 2019. Archived from the original on 28 December 2019. Retrieved 30 March 2020. The MHRA has issued an alert to healthcare professionals, as GlaxoSmithKline is recalling all unexpired stock of four types of Zantac, the medicine used to treat conditions such as heartburn and stomach ulcers.
  94. ^ "Class 2 Medicines recall: Ranitidine Effervescent Tablets 150mg, Ranitidine Effervescent Tablets 300mg (EL (19)A/27)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 17 October 2019. Archived from the original on 28 January 2020. Retrieved 30 March 2020. Teva UK Limited trading as ratiopharm GmbH is recalling all unexpired stock of Ranitidine Effervescent Tablets from pharmacies.
  95. ^ "Press release – Ranitidine – MHRA drug alert issued for Teva UK recall". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 17 October 2019. Archived from the original on 28 February 2020. Retrieved 30 March 2020. Teva UK Ltd is recalling unexpired stock of certain batches of 2 types of Ranitidine medicines used to treat conditions such as heartburn and stomach ulcers.
  96. ^ "Class 2 Medicines recall: Ranitidine 150mg/10ml Oral Solution (EL (19)A/29)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency. 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. Rosemont Pharmaceuticals Limited is recalling unexpired stock from pharmacies as a precautionary measure due to possible contamination with an impurity.
  97. ^ "Class 2 Medicines recall: Zantac 75 Relief Tablets, Zantac 75 Tablets, Galpharm Indigestion Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets, Kirkland Indigestion Relief 75mg Tablets, Morrisons Indigestion & Heartburn Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets (EL (19)A/30)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. Omega Pharma Limited and Galpharm International Limited are recalling unexpired stock from pharmacies and retail stores as a precautionary measure due to possible contamination with an impurity.
  98. ^ "Press release – Ranitidine – MHRA drug alerts issued as Perrigo recalls prescription only and over-the-counter products". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. The MHRA has issued alerts to healthcare professionals and retailers, as Perrigo Company plc is recalling all unexpired stock of certain batches of Ranitidine medicines used to treat conditions such as heartburn and stomach ulcers.
  99. ^ "Class 2 Medicines Recall: Ranitidine Oral Solution 30mg/ml, PL 31862/0023, Ranitidine 150mg Tablets, PL 11311/0138 (EL(19)A/36)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 19 November 2019. Archived from the original on 21 January 2020. Retrieved 30 March 2020. Creo Pharma Limited and Tillomed Laboratories Limited are recalling all unexpired stock of the products listed in this alert.
  100. ^ "Press release – Ranitidine Oral Solution and Tablets recall". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 19 November 2019. Archived from the original on 20 November 2019. Retrieved 30 March 2020. Ranitidine – MHRA drug alert issued as Creo Pharma Limited and Tillomed Laboratories recall unexpired stock.
  101. ^ "Class 2 Medicines recall: Ranitidine 75mg Tablets, (various liveries) (EL(19)A/37)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 21 November 2019. Archived from the original on 21 February 2020. Retrieved 30 March 2020. OTC Concepts Ltd, Relonchem Ltd, Noumed Life Sciences Ltd and Medreich Plc. are recalling stock from pharmacies and retail stores as a precautionary measure due to possible contamination with an impurity.
  102. ^ "Press release – MHRA drug alert: recalls for 13 over-the-counter Ranitidine medicines". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 21 November 2019. Archived from the original on 22 November 2019. Retrieved 30 March 2020. A drug alert has been issued to retailers and healthcare professionals as 4 companies are recalling batches of certain over-the-counter Ranitidine medicines used to treat conditions such as stomach ulcers and heartburn.
  103. ^ "Class 2 Medicines recall: Ranitidine 150mg Film-Coated Tablets, PL 20075/0063, Ranitidine 300mg Film-Coated Tablets, PL 20075/0064 (EL(19)A/40)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 5 December 2019. Archived from the original on 4 March 2020. Retrieved 30 March 2020. Accord Healthcare are recalling all unexpired stock of the below products from pharmacies and retail stores as a precautionary measure.
  104. ^ "Class 2 Medicines Recall: Medley Pharma Limited, Ranitidine 150mg Tablets BP, PL 43870/0026, Ranitidine 300mg Tablets BP, PL 43870/0027 (EL(19)A/41)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 16 December 2019. Archived from the original on 5 March 2020. Retrieved 30 March 2020. Medley Pharma Limited is recalling all unexpired stock of the below products from pharmacies and retail stores as a precautionary measure.
  105. ^ "Class 2 Medicines recall: Medreich PLC, Ranitidine 150mg Tablets, PL 21880/0091, Ranitidine 300mg Tablets, PL 21880/0092 (EL (20)A/05)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 3 February 2020. Archived from the original on 16 June 2020. Retrieved 30 March 2020. Medreich Plc is recalling all unexpired stock of the above products from pharmacies and wholesalers as a precautionary measure due to possible contamination with an impurity N-nitrosodimethylamine (NDMA) which has genotoxic and carcinogenic potential.
  106. ^ "MHRA Central Alerting System – Ranitidine: all oral formulations. Supply disruption". CAS.MHRA.GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 15 October 2019. Archived from the original on 13 August 2020. Retrieved 30 March 2020. All oral formulations of ranitidine are shortly anticipated to be out of stock until further notice. This alert provides healthcare professionals with advice on the management of patients currently taking ranitidine.
  107. ^ Thomas K (18 October 2019). "Zantac recall widens as Sanofi pulls its drug over carcinogen fears". The New York Times. Archived from the original on 18 October 2019. Retrieved 18 October 2019.
  108. ^ "Sanofi provides update on precautionary voluntary recall of Zantac OTC in U.S." U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  109. ^ "Perrigo Company plc issues voluntary worldwide recall of Ranitidine due to possible presence of impurity, N-nitrosodimethylamine (NDMA) impurity in the product". U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  110. ^ "Dr. Reddy's confirms its voluntary nationwide recall of all Ranitidine products in the U.S. market". U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  111. ^ "Novitium Pharma issues voluntary national recall of Ranitidine Hydrochloride capsules 150mg and 300mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 25 October 2019. Archived from the original on 29 October 2019. Retrieved 28 October 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  112. ^ "Aurobindo Pharma USA, Inc. initiates voluntary nationwide consumer level recall of 38 lots of Ranitidine tablets 150mg, Ranitidine capsules 150mg, Ranitidine capsules 300mg and ranitidine Syrup 15mg/mL due to the detection of NDMA (Nitrosodimethylamine) impurity". U.S. Food and Drug Administration (FDA) (Press release). 6 November 2019. Archived from the original on 11 November 2019. Retrieved 10 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  113. ^ "Amneal Pharmaceuticals, LLC. issues voluntary nationwide recall of Ranitidine tablets, USP, 150mg and 300mg, and Ranitidine syrup (Ranitidine Oral Solution, USP), 15 mg/mL, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA) (Press release). 12 November 2019. Archived from the original on 12 November 2019. Retrieved 12 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  114. ^ "American Health Packaging issues voluntary nationwide recall of Ranitidine syrup (Ranitidine Oral Solution USP) 150 mg/10 mL liquid unit dose cups due to the detection of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA) (Press release). 8 November 2019. Archived from the original on 12 November 2019. Retrieved 12 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  115. ^ "Golden State Medical Supply, Inc. issues a voluntary nationwide recall of Ranitidine hydrochloride 150mg and 300mg capsules (manufactured by Novitium Pharma LLC) due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA) (Press release). 15 November 2019. Archived from the original on 23 November 2019. Retrieved 22 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  116. ^ "Precision Dose Inc. issues voluntary nationwide recall of ranitidine oral solution, USP 150 mg/10 mL due to possible presence of N-nitrosodimethylamine impurity". U.S. Food and Drug Administration (FDA) (Press release). 19 November 2019. Archived from the original on 23 November 2019. Retrieved 22 November 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  117. ^ "Glenmark Pharmaceuticals Inc., USA voluntarily recalls all unexpired lots of its Ranitidine tablets and ceases distribution, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 17 December 2019. Archived from the original on 18 December 2019. Retrieved 18 December 2019.
  118. ^ "Appco Pharma LLC issues voluntary nationwide recall of Ranitidine hydrochloride capsules 150 mg and 300 mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 7 January 2020. Archived from the original on 9 January 2020. Retrieved 8 January 2020.
  119. ^ "Denton Pharma, Inc. dba Northwind Pharmaceuticals voluntarily recalls all unexpired lots of its Ranitidine tablets and ceases distribution, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 6 January 2020. Archived from the original on 9 January 2020. Retrieved 8 January 2020.
  120. ^ "American Health Packaging issues voluntary nationwide recall of Ranitidine tablets, USP 150 mg, 100 count unit dose blisters due to the detection of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 27 February 2020. Archived from the original on 28 February 2020. Retrieved 28 February 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  121. ^ "All Ranitidine Products (Zantac): Press Release - FDA Requests Removal". U.S. Food and Drug Administration (FDA). 1 April 2020. Archived from the original on 6 May 2020. Retrieved 6 May 2020.
  122. ^ "Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 28-30 April 2020". European Medicines Agency (EMA). 30 April 2020. Archived from the original on 7 May 2020. Retrieved 6 May 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  123. ^ "Ranitidine: medicine to lower stomach acid". NHS (UK). 16 July 2021. Archived from the original on 3 December 2021. Retrieved 3 December 2021.
  124. ^ a b c Connelly D (4 October 2021). "Return of ranitidine being considered by UK manufacturer". The Pharmaceutical Journal. Archived from the original on 3 December 2021. Retrieved 3 December 2021.
  125. ^ a b c d e f Morgan KA, Ahlawat R (2023). "Ranitidine". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 30422583. Archived from the original on 22 March 2023. Retrieved 8 August 2023.
  126. ^ Roberts CJ (1984). "Clinical pharmacokinetics of ranitidine". Clinical Pharmacokinetics. 9 (3): 211–221. doi:10.2165/00003088-198409030-00003. PMID 6329583. S2CID 21561498.
  127. ^ "Zantac (ranitidine hydrochloride)" (PDF). Food and Drug Administration (FDA); GlaxoSmithKline (GSK). April 2009. Archived (PDF) from the original on 21 June 2022. Retrieved 8 August 2023. via DrugBank database Archived 10 August 2023 at the Wayback Machine
  128. ^ "Ranitidine Hydrochloride". DailyMed. August 2020. Archived from the original on 10 August 2023. Retrieved 8 August 2023.
  129. ^ Lednicer D, ed. (1993). Chronicles of Drug Discovery. ACS Professional Reference Book. Vol. 3. John Wiley & Sons. pp. 45–81. ISBN 978-0-8412-2733-0.
  130. ^ US patent 4128658, "Aminoalkyl furan derivatives" 
  131. ^ Brunton L, Lazo J, Parker K (August 2005). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 ed.). McGraw-Hill. p. 972. ISBN 978-0-07-142280-2. Archived from the original on 11 April 2016.
  132. ^ Li JJ (2014). "Beginning of an Era: The First Blockbuster Drug, Tagamet". academic.oup.com. doi:10.1093/oso/9780199737680.003.0005. ISBN 978-0-19-973768-0. Retrieved 22 October 2024.
  133. ^ Pelot, Daniel, (M.D.). "Digestive System : New Drug for Heartburn". The New Book of Knowledge : Medicine & Health, Grolier : Danbury, Connecticut. 1990. p.262. ISBN 0-7172-8244-9. Library of Congress 82-645223
  134. ^ Yeomans ND, Tulassay Z, Juhász L, Rácz I, Howard JM, van Rensburg CJ, et al. (March 1998). "A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group". The New England Journal of Medicine. 338 (11): 719–726. doi:10.1056/NEJM199803123381104. PMID 9494148.
  135. ^ "Zantac". U.S. Food and Drug Administration (FDA). NDA 021698. Archived from the original on 30 October 2019. Retrieved 18 October 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  136. ^ "CVS suspends Zantac sales, as recalls widen over carcinogen fears". BioPharma Dive. 30 September 2019. Archived from the original on 19 October 2019. Retrieved 18 October 2019.

Notes

  1. ^ Zantac in the United States is now a brand of famotidine.
  2. ^ Gastric, pancreatic, and lung cancer risk increased by up to 26%, 35%, and 17%, respectively, but "only liver cancer displayed a significant association with long-term ranitidine use" and "there was no continuous dose–response relationship among the other individual cancers".[23]
  3. ^ Overall cancer risk increased by 10%, p < 0.001[23]

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Bouygues

Bouygues S.A.JenisSociété AnonymeKode emitenEuronext: ENKomponen CAC 40IndustriKonglomeratDidirikan1952; 72 tahun lalu (1952)PendiriFrancis BouyguesKantorpusat8th arrondissement, Paris, PrancisTokohkunciMartin Bouygues (Chairman dan CEO)ProdukTeknik sipil, pengembangan lahan yasan, media, dan telekomunikasiPendapatan €35,55 milyar (2018)[1]Laba operasi €1,511 milyar (2018)[1]Laba bersih €1,311 milyar (2018)[1]Karyawan129.000 (2017)[2]Anakusaha...

 

Temperature–entropy diagram

Graph relating temperature and entropy during a thermodynamic process or cycle For other uses, see Tanabe–Sugano diagram. ThermodynamicsThe classical Carnot heat engine Branches Classical Statistical Chemical Quantum thermodynamics Equilibrium / Non-equilibrium Laws Zeroth First Second Third Systems Closed system Open system Isolated system State Equation of state Ideal gas Real gas State of matter Phase (matter) Equilibrium Control volume Instruments Processes Isobaric Isochoric I...

 

Ligne Yokohama

LigneYokohama Ligne de Higashi-Kanagawa à Hachiōji Carte de la ligne Une automotrice série E233 sur la ligne Yokohama Pays Japon Villes desservies Yokohama, Machida, Sagamihara, Hachiōji Historique Mise en service 1908 Électrification 1925 – 1941 Caractéristiques techniques Longueur 42,6 km Vitesse maximale commerciale 95 km/h Écartement étroit (1 067 mm) Électrification 1500 V continu Nombre de voies Double voie Trafic Propriétaire JR East Exploitant(s) JR Ea...

Teori kebocoran laboratorium Covid-19

Institut Virologi Wuhan, target dari teori tersebut. Hipotesis kebocoran lab Covid-19 mencetuskan bahwa SARS-CoV-2 (virus yang menyebabkan COVID-19) bocor dari sebuah lab, di Wuhan, Tiongkok, yang menimbulkan pandemi COVID-19.[1][2] Hipotesis tersebut utamanya datang dari bukti tak langsung yang menyatakan bahwa Institut Virologi Wuhan dekat dengan tempat wabah awal dari pandemi COVID-19 di Wuhan, Provinsi Hubei, Tiongkok.[3] Bagian utama dari hipotesis tersebut menyat...

 

Bengawan Solo (lagu)

Untuk kegunaan lain, lihat Bengawan Solo (disambiguasi). Bengawan SoloLagu oleh GesangDirilis1940GenreKeroncongPenciptaGesang Bengawan Solo adalah sebuah lagu karya Gesang yang menceritakan tentang aliran Sungai Bengawan Solo.[1] Gesang menciptakan lagu ini pada tahun 1940 pada saat Gesang berumur 23 tahun.[2] Selain terkenal di Indonesia, lagu ini merupakan lagu yang terkenal di seluruh Asia semenjak diperkenalkan oleh para tentara Jepang.[2] Sejak saat itu, Bengawan ...

 

Csobaj

This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Csobaj – news · newspapers · books · scholar · JSTOR (July 2016) (Learn how and when to remove this template message) Place in Borsod-Abaúj-Zemplén, HungaryCsobaj Coat of armsCsobajCoordinates: 48°02′56″N 21°20′09″E / 48.048961°N 21.335769°E...

Coppa del mondo per club FIFA 2018

Coppa del Mondo per club FIFA 2018كأس العالم للأندية FIFA 2018kas alealam lil'andiat FIFA 2018 Competizione Coppa del mondo per club FIFA Sport Calcio Edizione 15ª Organizzatore FIFA Date 12 - 22 dicembre 2018 Luogo  Emirati Arabi Uniti(2 città) Partecipanti 7 Impianto/i 2 stadi Risultati Vincitore Real Madrid(4º titolo) Secondo Al-Ain Terzo River Plate Quarto Kashima Antlers Statistiche Miglior giocatore Gareth Bale Miglior marcatore Gareth Bale Rafael Sant...

 

Susan Brooks

Susan Brooks Susan Lynn Wiant Brooks (lahir 25 Agustus 1960) adalah seorang politikus Amerika Serikat. Ia berasal dari Partai Republik dan mantan anggota DPR. Pranala luar Wikimedia Commons memiliki media mengenai Susan Brooks. Susan Brooks di Curlie (dari DMOZ) Kemunculan di C-SPAN Biografi di Biographical Directory of the United States Congress Catatan suara dikelola oleh The Washington Post Biografi, catatan suara, dan penilaian kelompok kepentingan di Project Vote Smart Laporan dan data k...

 

李光耀之死

李光耀逝世及葬礼李光耀（1923年－2015年）日期2015年3月23日－2015年3月29日地点新加坡斯里淡马锡（私人守灵）新加坡国会大厦（民众瞻仰）新加坡国立大学文化中心（国葬）万礼火葬场（英语：Mandai Crematorium and Columbarium）（火葬）网站www.rememberingleekuanyew.sg 2015年3月23日凌晨3時18分（新加坡標準時間），新加坡建国后首任总理、前內閣资政和执政人民行动党首任秘书长李光�...

ويل د. كوب

هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (أبريل 2019) ويل د. كوب معلومات شخصية تاريخ الميلاد 6 يوليو 1876   تاريخ الوفاة 20 يناير 1930 (53 سنة)   مواطنة الولايات المتحدة  الحياة العملية المهنة كاتب أغاني  الموا�...

 

Ferdinando Facchiano

Italian lawyer and politician (1927–2022) Ferdinando FacchianoFacchiano in 1987Minister for the Coordination of Civil Protection [it]In office28 June 1992 – 29 April 1993Preceded byNicola CapriaSucceeded byVito Riggio [it]Minister of Merchant Navy [it]In office13 April 1991 – 28 June 1992Preceded byCarlo VizziniSucceeded byGiancarlo TesiniMinister for Cultural and Environmental HeritageIn office23 July 1989 – 13 April 1...

 

Nuweiba

You can help expand this article with text translated from the corresponding article in Arabic. (April 2019) Click [show] for important translation instructions. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia. Do not translate text that appears unreliable or low-q...

Biplab Kumar Deb

Biplab Kumar Deb Ketua Menteri Tripura ke-10PetahanaMulai menjabat 9 Maret 2018[1]GubernurTathagata RoyPendahuluManik SarkarPenggantiPetahana Informasi pribadiLahir25 November 1971 (umur 52)Bangladesh[2]Partai politikBJPSuami/istriNiti DebAnak1 putri dan 1 putraAlma materUniversitas TripuraSunting kotak info • L • B Biplab Kumar Deb (lahir 25 November 1971)[3] adalah seorang politikus India dan Ketua Menteri Tripura. Ia menjadi presiden tingkat n...

 

Fujii Kaze

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada November 2022. Dalam artikel ini, nama keluarganya adalah Fujii. Fujii KazeLahir14 Juni 1997 (umur 27)[1]Satoshō, Okayama, Jepang[1]AsalJepangGenreJ-poprockR&BPekerjaan Pemusik Penyanyi-penulis lagu Instrumen Vokal piano electone saksofon T...

 

Douglas XP-48

Douglas XP-48 adalah, pesawat tempur ringan kecil sayap rendah (low wing), dirancang oleh Douglas Aircraft pada tahun 1939 untuk evaluasi oleh Angkatan Udara Amerika Serikat. Dimaksudkan untuk didukung oleh mesin piston inline kecil, kontrak itu dibatalkan sebelum prototipe dapat dibangun, karena kekhawatiran Angkatan Darat tentang proyeksi kinerja pesawat.[1] Referensi ^ Douglas XP-48. National Museum of the United States Air Force. Accessed May 9 2010. Adcock, Al. OS2U Kingfisher i...

السلطنة القعيطية

تحتاج هذه المقالة إلى الاستشهاد بمصادر إضافية لتحسين وثوقيتها. فضلاً ساهم في تطوير هذه المقالة بإضافة استشهادات من مصادر موثوق بها. من الممكن التشكيك بالمعلومات غير المنسوبة إلى مصدر وإزالتها. (نوفمبر 2022) إن وجهات النظر المعروضة في هذه المقالة منحازة ثقافيًا أو جغرافيًا. ف...

 

Tour de France 1987

Tour de France 1987GénéralitésCourse 74e Tour de FranceCompétition Super Prestige Pernod 1987 (d)Étapes 26Date 1er au 26 juillet 1987Distance 4 231 kmPays traversé(s) France, RFALieu de départ Berlin-OuestLieu d'arrivée ParisPartants 207Vitesse moyenne 36,645 km/hRésultatsVainqueur Stephen RocheDeuxième Pedro DelgadoTroisième Jean-François BernardClassement par points Jean-Paul van PoppelMeilleur grimpeur Luis HerreraMeilleur jeune Raúl AlcaláVainqueur du combiné...

 

Rabbit-Proof Fence

Rabbit-Proof FencePosterSutradaraPhillip NoyceProduserPhillip NoyceChristine OlsenJohn Winter (producer)SkenarioChristine OlsenBerdasarkanFollow the Rabbit-Proof Fenceoleh Doris Pilkington GarimaraPemeranEverlyn SampiTianna SansburyLaura MonaghanDavid GulpililKenneth BranaghPenata musikPeter GabrielSinematograferChristopher DoylePenyuntingVeronika JenetJohn ScottPerusahaanproduksiRumbalara FilmsOlsen LevyShowtime AustraliaDistributorBecker EntertainmentTanggal rilis 04 Februari 2002...

第13回日本レコード大賞

第13回日本レコード大賞 会場として使われた帝国劇場ジャンル 特別番組 / 音楽番組演出 小松敬出演者 高橋圭三山本陽子沢田雅美ほか製作プロデューサー 高石昭年、砂田実、井田舒也、井原利一制作 TBSテレビ 放送音声形式モノラル放送放送国・地域 日本放送期間1971年12月31日放送時間金曜19:00 - 20:56放送枠日本レコード大賞放送分116分回数1テンプレートを表示 第13回日...

 

佳子内親王

この項目では、秋篠宮文仁親王第2女子について説明しています。第71代・後三条天皇第3皇女については「佳子内親王 (後三条天皇皇女)」をご覧ください。 佳子内親王 秋篠宮家 2020年（令和2年）5月1日 撮影続柄 秋篠宮文仁親王第2女子[1]全名 佳子（かこ）身位 内親王敬称 殿下お印 ゆうな出生 (1994-12-29) 1994年12月29日（29歳） 日本・東京都千代田区千代田皇居・宮�...