2021 Winston-Salem Open
Date	August 21–28
Edition	52nd
Category	ATP Tour 250 Series
Draw	48S / 16D
Surface	Hard / outdoor
Location	Winston-Salem, North Carolina, U.S.
Venue	Wake Forest University
Champions
Singles
Ilya Ivashka
Doubles
Marcelo Arévalo / Matwé Middelkoop
← 2019 · Winston-Salem Open · 2022 →

The 2021 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 52nd edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP Tour 250 Series of the 2021 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 21 through August 28, 2021. It was the last event on the 2021 US Open Series before the 2021 US Open.^[1]

• Ilya Ivashka def. Mikael Ymer, 6–0, 6–2

• Marcelo Arévalo / Matwé Middelkoop def. Ivan Dodig / Austin Krajicek, 6–7^(5–7), 7–5, [10–6]

_{*per team}

Country	Player	Rank1	Seed
ESP	Pablo Carreño Busta	12	1
BEL	David Goffin	19	2
GBR	Dan Evans	28	3
HUN	Márton Fucsovics	37	4
KAZ	Alexander Bublik	38	5
CRO	Marin Čilić	39	6
GEO	Nikoloz Basilashvili	40	7
AUS	John Millman	44	8
GER	Jan-Lennard Struff	47	9
ARG	Federico Delbonis	48	10
ESP	Albert Ramos Viñolas	49	11
FRA	Benoît Paire	50	12
USA	Frances Tiafoe	51	13
FRA	Richard Gasquet	53	14
ESP	Carlos Alcaraz	55	15
GER	Dominik Koepfer	59	16

¹ Rankings are as of August 16, 2021 ^[2]

The following players received wildcards into the singles main draw:

• Pablo Carreño Busta
• David Goffin
• Dan Evans
• Andy Murray

The following player received entry using a protected ranking into the singles main draw:

• Gilles Simon

The following players received entry from the qualifying draw:

• Denis Kudla
• Alexei Popyrin
• Lucas Pouille
• Wu Tung-lin

The following players received entry as lucky losers:

• Pierre-Hugues Herbert
• Eduardo Nava
• Max Purcell
• Noah Rubin
• Yosuke Watanuki

Before the tournament

• Kevin Anderson → replaced by Arthur Rinderknech
• Pablo Andújar → replaced by Marco Cecchinato
• Nikoloz Basilashvili → replaced by Pierre-Hugues Herbert
• Aljaž Bedene → replaced by Tennys Sandgren
• Laslo Đere → replaced by Mikael Ymer
• David Goffin → replaced by Eduardo Nava
• Lloyd Harris → replaced by Norbert Gombos
• Nick Kyrgios → replaced by Noah Rubin
• Adrian Mannarino → replaced by Thiago Monteiro
• John Millman → replaced by Max Purcell
• Yoshihito Nishioka → replaced by Facundo Bagnis
• Miomir Kecmanović → replaced by Radu Albot
• Tommy Paul → replaced by Andreas Seppi
• Lorenzo Sonego → replaced by Yosuke Watanuki

Country	Player	Country	Player	Rank1	Seed
POL	Łukasz Kubot	BRA	Marcelo Melo	37	1
FRA	Nicolas Mahut	FRA	Fabrice Martin	40	2
RSA	Raven Klaasen	JPN	Ben McLachlan	52	3
ITA	Simone Bolelli	ARG	Máximo González	60	4

¹ Rankings are as of August 16, 2021

The following pairs received wildcards into the doubles main draw:

• Siddhant Banthia / Matthew Thomson
• Nicholas Monroe / Jackson Withrow

Before the tournament

• Ivan Dodig / Jamie Murray → replaced by Ivan Dodig / Austin Krajicek
• Marcel Granollers / Horacio Zeballos → replaced by Oliver Marach / Philipp Oswald
• Wesley Koolhof / Jean-Julien Rojer → replaced by Ariel Behar / Gonzalo Escobar
• Kevin Krawietz / Horia Tecău → replaced by Tomislav Brkić / Nikola Ćaćić
• John Peers / Filip Polášek → replaced by Marcus Daniell / Marcelo Demoliner
• Tim Pütz / Michael Venus → replaced by Luke Saville / John-Patrick Smith
• Rajeev Ram / Joe Salisbury → replaced by Marcelo Arévalo / Matwé Middelkoop

• Official website