Singles
2021 Córdoba Open
Final
Champion	Juan Manuel Cerúndolo
Runner-up	Albert Ramos Viñolas
Score	6–0, 2–6, 6–2
Details
Draw	28 (4 Q / 3 WC )
Seeds	8
Events
Singles Doubles
← 2020 · Córdoba Open · 2022 →

Cristian Garín was the defending champion, but chose not to defend his title.

Juan Manuel Cerúndolo won the title, defeating Albert Ramos Viñolas in the final 6–0, 2–6, 6–2. Cerúndolo, who started the week ranked 335th and went through qualifying, became the first player to win a tournament on his ATP Tour debut since Santiago Ventura in 2004.

The top four seeds received a bye into the second round.

	Semifinals							Final
	5	Albert Ramos Viñolas	7	5	6
	Q	Facundo Bagnis	5	7	3
								5	Albert Ramos Viñolas	0	6	2
								Q	Juan Manuel Cerúndolo	6	2	6
	Q	Juan Manuel Cerúndolo	6	4	6
		Federico Coria	4	6	2

	First round							Second round							Quarterfinals							Semifinals
								1	D Schwartzman	6	6
		H Dellien	2	6	1				M Cecchinato	2	2
		M Cecchinato	6	4	6										1	D Schwartzman	1	6	3
	Q	TM Etcheverry	6	77											5	A Ramos Viñolas	6	4	6
		A Martin	3	64				Q	TM Etcheverry	6	65	5
		JI Londero	6	2	2			5	A Ramos Viñolas	2	77	7
	5	A Ramos Viñolas	4	6	6																	5	A Ramos Viñolas	7	5	6
																						Q	F Bagnis	5	7	3
								Q	MT Barrios Vera	6	2	3
		DE Galán	2	6	3				J Kovalík	4	6	6
		J Kovalík	6	1	6											J Kovalík	1	2
	Q	F Bagnis	6	6											Q	F Bagnis	6	6
	WC	N Kicker	1	4				Q	F Bagnis	6	7
		P Sousa	4	4				8	F Delbonis	4	5
	8	F Delbonis	6	6

	First round							Second round							Quarterfinals							Semifinals
	7	T Monteiro	6	6
	LL	J Menezes	3	3				7	T Monteiro	6	6
		R Carballés Baena	6	6					R Carballés Baena	3	4
		J Sousa	3	1											7	T Monteiro	2	6	3
	Q	JM Cerúndolo	7	77											Q	JM Cerúndolo	6	2	6
		T Seyboth Wild	5	63				Q	JM Cerúndolo	63	7	6
								3	M Kecmanović	77	5	2
																						Q	JM Cerúndolo	6	4	6
	6	D Koepfer	1	4																			F Coria	4	6	2
		F Coria	6	6					F Coria	1	6	6
	WC	F Cerúndolo	63	6	6			WC	F Cerúndolo	6	2	4
		G Mager	77	1	4											F Coria	6	6
		J Munar	7	65	4										2	B Paire	3	2
	WC	N Jarry	5	77	6			WC	N Jarry	2	4
								2	B Paire	6	6

	First round							Second round							Qualifying competition
	1	Facundo Bagnis	6	4	6
		Thiago Agustín Tirante	3	6	4
								1	Facundo Bagnis	77	6
									Andrea Collarini	65	3
		Hernán Casanova	2	63
		Andrea Collarini	6	77
															1	Facundo Bagnis	6	6
																Pedro Sakamoto	2	4
		Guilherme Clezar	4	4
		Renzo Olivo	6	6
									Renzo Olivo	2	5
									Pedro Sakamoto	6	7
		Pedro Sakamoto	3	6	77
	5	Emilio Gómez	6	1	65

	First round							Second round							Qualifying competition
	2	Leonardo Mayer	61	711	3
		Tomás Martín Etcheverry	77	69	6
									Tomás Martín Etcheverry	7	6
									Christian Lindell	5	2
		Facundo Mena	1	0r
		Christian Lindell	6	0
																Tomás Martín Etcheverry	7	7
																Ernesto Escobedo	5	5
		Ernesto Escobedo	77	4	6
		Lukáš Klein	64	6	1
									Ernesto Escobedo	6	6
									Felipe Meligeni Alves	4	1
		Felipe Meligeni Alves	6	6
	7	João Domingues	2	2

	First round							Second round							Qualifying competition
	3	Sumit Nagal	4	6	3
		Facundo Díaz Acosta	6	2	6
									Facundo Díaz Acosta	6	3	2
									Camilo Ugo Carabelli	4	6	6
	WC	Mariano Kestelboim	0	4
		Camilo Ugo Carabelli	6	6
																Camilo Ugo Carabelli	63	64
																Marcelo Tomás Barrios Vera	77	77
		Marcelo Tomás Barrios Vera	6	6
		Nicolás Álvarez	1	2
									Marcelo Tomás Barrios Vera	6	6
									Agustín Velotti	3	4
		Agustín Velotti	6	6
	8	Mario Vilella Martínez	3	4

	First round							Second round							Qualifying competition
	4	Juan Pablo Varillas	63	6	6
	WC	Matías Franco Descotte	77	0	0
								4	Juan Pablo Varillas	67	3
									Juan Manuel Cerúndolo	79	6
		Juan Manuel Cerúndolo	6	6
	WC	Fermín Tenti	0	4
																Juan Manuel Cerúndolo	6	6
																João Menezes	4	4
		João Menezes	6	77
	WC	Guido Iván Justo	3	64
									João Menezes	6	6
									Carlos Gómez-Herrera	1	1
		Carlos Gómez-Herrera	6	7
	6	Guido Andreozzi	3	5

• Main draw
• Qualifying draw