Men's singles
2021 Eastbourne International
Final
Champion	Alex de Minaur
Runner-up	Lorenzo Sonego
Score	4–6, 6–4, 7–6(7–5)
Events
Singles men women Doubles men women
← 2019 · Eastbourne International · 2022 →

Alex de Minaur defeated Lorenzo Sonego in the final, 4–6, 6–4, 7–6^(7–5), to win the men's singles tennis title at the 2021 Eastbourne International. It was De Minaur's fifth career ATP Tour singles title and his first on grass. Sonego was contesting in his second grass final to win his third career title.^[1]

Taylor Fritz was the defending champion from when the event was last held in 2019,^[2] but he withdrew before the beginning of the tournament after incurring a knee injury during the French Open.^[3]

The top four seeds received a bye into the second round.

	Semifinals							Final
	LL	Max Purcell	1	6	1
	3	Lorenzo Sonego	6	3	6
								3	Lorenzo Sonego	6	4	65
								2	Alex de Minaur	4	6	77
	LL	Kwon Soon-woo	3	62
	2	Alex de Minaur	6	77

	First round							Second round							Quarterfinals							Semifinals
								1	G Monfils	4	7	4
	LL	M Purcell	6	3	77			LL	M Purcell	6	5	6
	Q	J Duckworth	2	6	65										LL	M Purcell	6	1	6
	LL	A Seppi	77	6											LL	A Seppi	4	6	4
		Y Nishioka	65	1				LL	A Seppi	6	6
		E Ruusuvuori	6	6					E Ruusuvuori	2	3
	7	A Ramos Viñolas	4	3																		LL	M Purcell	1	6	1
																						3	L Sonego	6	3	6
								3	L Sonego	6	6
		J Millman	6	6					J Millman	4	2
	WC	J Clarke	3	2											3	L Sonego	6	7
		J-W Tsonga	3	4											8	A Bublik	1	5
		E Gerasimov	6	6					E Gerasimov	2	2
	Q	M Kukushkin	1	4				8	A Bublik	6	6
	8	A Bublik	6	6

	First round							Second round							Quarterfinals							Semifinals
	LL	N Gombos	6	4	1
		A Popyrin	4	6	6				A Popyrin	77	5	3
	LL	A Gray	2	65				Q	I Ivashka	65	7	6
	Q	I Ivashka	6	77											Q	I Ivashka	4	5
		M Fucsovics	77	3	77										LL	S-w Kwon	6	7
		A Bedene	63	6	63				M Fucsovics	64	77	3
								LL	S-w Kwon	77	64	6
																						LL	S-w Kwon	3	62
	6	A Davidovich Fokina	7	6																		2	A de Minaur	6	77
	Q	M Ymer	5	1				6	A Davidovich Fokina	61	0r
	WC	J Ward	4	4					V Pospisil	77	0
		V Pospisil	6	6												V Pospisil	4	4
		F Tiafoe	3	64											2	A de Minaur	6	6
	WC	L Broady	6	77				WC	L Broady	3	4
								2	A de Minaur	6	6

	First round							Qualifying competition
	1	Kwon Soon-woo	6	2	3
	WC	Alastair Gray	4	6	6
								WC	Alastair Gray	3	64
								5	James Duckworth	6	77
		Filip Jianu	4	3
	5	James Duckworth	6	6

	First round							Qualifying competition
	2	Norbert Gombos	6	77
	WC	Lui Maxted	4	64
								2	Norbert Gombos	3	5
								6	Mikael Ymer	6	7
		Geoffrey Blancaneaux	6	2	1
	6	Mikael Ymer	1	6	6

	First round							Qualifying competition
	3	Ilya Ivashka	6	77
	Alt	John-Patrick Smith	4	63
								3	Ilya Ivashka	66	6	6
									Max Purcell	78	2	1
		Max Purcell	79	4	6
	7	Kevin Anderson	67	6	3

	First round							Qualifying competition
	4	Andreas Seppi	6	6
		Christian Harrison	3	3
								4	Andreas Seppi	2	5
								8	Mikhail Kukushkin	6	7
		Nick Chappell	2	3
	8	Mikhail Kukushkin	6	6

• Main draw
• Qualifying draw