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Dies ist eine Auflistung von Interstate Highways in den USA. Zur Klassifizierung siehe Interstate Highway.

Nummer	Beginn	Ende	Länge mi	Länge km	Zubringer und Umgehungen
I-2	Palmview	Harlingen	47	75
I-4	Tampa	Daytona Beach	132	212
I-5	San Ysidro	Blaine	1381	2222	I-105 (CA, OR), I-205 (CA, OR/WA), I-405 (CA, OR, WA), I-505, I-605 (CA, WA), I-705, I-805
I-8	San Diego	Casa Grande	350	564
I-10	Santa Monica	Jacksonville	2460	3960	I-110 (FL, CA, LA, MS, TX), I-210 (CA, LA), I-310, I-410, I-510, I-610 (LA, TX), I-710, I-910
I-11	Boulder City	Henderson	23	37
I-12	Baton Rouge	Slidell	85	137
I-14	Copperas Cove	Belton	25	40
I-15	San Diego	Sweetgrass	1433	2307	I-115, I-215 (CA, NV, UT), I-315, I-515
I-16	Macon	Savannah	166	268	I-516
I-17	Phoenix	Flagstaff	146	235
I-19	Nogales	Tucson	63	102
I-20	Kent	Florence	1535	2470	I-220 (MS, LA), I-520, I-820
I-22	Memphis	Birmingham	176	283
I-24	Pulleys Mill	Chattanooga	316	509
I-25	Las Cruces	Buffalo	1063	1711	I-225
I-26	Morrison City	Charleston	347	558	I-126, I-526
I-27	Lubbock	Amarillo	124	200
I-29	Kansas City	Pembina	755	1215	I-129, I-229 (SD, MO)
I-30	Fort Worth	Little Rock	366	590	I-130, I-430, I-530, I-630
I-35	Laredo	Duluth	1565	2518	I-35W, I-35E, I-135, I-235 (OK, IA, KS), I-335, I-435, I-535, I-635 (KS/MO, TX)
I-37	Corpus Christi	San Antonio	143	230
I-39	Normal	Wausau	323	520
I-40	Barstow	Wilmington	2554	4110	I-140 (NC, TN), I-240 (NC, OK, TN), I-440 (AR, NC, OK, TN), I-540 (AK, NC), I-640, I-840 (NC, TN)
I-41	Russell	Howard	176	284
I-43	Beloit	Green Bay	191	308
I-44	Wichita Falls	St. Louis	634	1021	I-244
I-45	Galveston	Dallas	285	459
I-49	Lafayette	Shreveport	208	335
I-55	LaPlace	Chicago	963	1561	I-155 (IL, MO/TN), I-255, I-355, I-555
I-57	Sikeston	Chicago	381	613
I-59	Slidell	Lookout Mountain	444	715	I-359, I-459, I-759
I-64	Weldon Spring	Portsmouth	960	1547	I-164, I-264 (KY, VA), I-464, I-564, I-646
I-65	Mobile	Gary	887	1426	I-165, I-265, I-465, I-565, I-865
I-66	Middletown	Washington	76	122
I-68	Morgantown	Hancock	116	187
I-69	Indianapolis	Port Huron	355	572	I-169 (KY, TX), I-269, I-369, I-469
I-70	Cove Fort	Baltimore	2173	3520	I-170 (MD, MO), I-270 (CO, IL/MO, MD, OH), I-370, I-470 (KS, MO, OH/WV), I-670 (KS/MO, OH)
I-71	Louisville	Cleveland	345	556	I-271, I-471
I-72	Hannibal	Champaign	186	301	I-172
I-73	Candor	Greensboro	26	42
I-74	Davenport	Candor	428	690	I-474
I-75	Sault St. Marie	Miami	1786	2874	I-175, I-275 (FL, MI, OH-IN-KY, TN), I-375 (FL, MI), I-475 (GA, MI, OH), I-575, I-675 (GA, MI, OH)
I-76W	Arvada	Big Springs	185	298
I-76E	Westfield Center	Camden	434	699	I-176, I-276, I-376, I-476, I-767
I-77	Columbia	Cleveland	611	984	I-277 (NC, OH)
I-78	Lickdale	New York City	143	231	I-278, I-678
I-79	Charleston	Erie	343	552	I-279, I-579
I-80	San Francisco	Ridgefield Park	2899	4666	I-180 (WY, NE, IL, PA), I-280 (CA, IL-IA, OH, NJ), I-380 (CA, IA, PA), I-480 (IA-NE, OH), I-580 (CA, NV, NE), I-680 (CA, IA-NE, OH), I-780, I-880, I-980
I-81	Dandridge	Alexandria Bay	846	1361	I-381, I-481, I-581
I-82	Ellensburg	Hermiston	143	231	I-182
I-83	Baltimore	Colonial Park	88	142	I-283
I-84W	Portland	Echo	770	1239	I-184
I-84E	Scranton	Sturbridge	231	372	I-384, I-684
I-85	Montgomery	Petersburg	668	1075	I-185 (GA, SC), I-285 (GA, NC), I-385, I-485, I-585, I-985
I-86W	Heyburn	Pocatello	63	101
I-86E	Erie	Elmira	191	308
I-87N	New York City	Champlain Town	333	536	I-287, I-587, I-787
I-87S	Raleigh	Wendell	13	21
I-88W	Moline	Chicago	140	226
I-88E	Binghamton	Schenectady	117	189
I-89	Concord	Highgate Springs	191	307	I-189
I-90	Seattle	Boston	3099	4958	I-190 (IL, MA, NY, SD), I-290 (IL, MA, NY), I-390, I-490 (OH, NY), I-590, I-690, I-790, I-890, I-990
I-91	New Haven	Derby Line	290	467	I-291 (MA, CT), I-391, I-691
I-93	Canton	St. Johnsbury	188	303	I-293, I-393
I-94	Billings	Port Huron	1604	2581	I-194 (MI, ND), I-294, I-394, I-494, I-649, I-794, I-894
I-95	Miami	Houlton	1927	3101	I 195 (FL, ME, MD, NJ, RI/MA, VA), I 295 (FL, NC, VA, DC, DE/NJ, NY, RI/MA, ME), I 395 (CT/MA, FL, VA, ME, MD, DC), I 495 (DC, DE, NY, MA, ME), I 595 (FL, MD), I 695 (DC, MD, NY), I 795 (FL, NC, MD), I 895 (MD, NY)
I-96	Muskegon	Detroit	192	309	I-196, I-496, I-696
I-97	Annapolis	Baltimore	17	28
I-99	Bedford	Bellefonte	51	82
I-238	Hayward	San Lorenzo	2	3
H-1	Makakilo	Honolulu	27	43	H-201
H-2	Pearl City	Wahiawa	8	13
H-3	Halawa Heights	Marine Corps Base Hawaii	15	24
A-1	Anchorage	kanadische Grenze	408	656
A-2	Tok	Fairbanks	202	325
A-3	Anchorage	Soldotna	148	238
A-4	Palmer	Fairbanks	323	520
PR-1	Ponce	San Juan	71	114
PR-2	Ponce	San Juan	138	222
PR-3	Ceiba	San Juan	40	65