PTP4A2

PTP4A2
Identifiers
Aliases	PTP4A2, HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b, protein tyrosine phosphatase type IVA, member 2, protein tyrosine phosphatase 4A2
External IDs	OMIM: 601584; MGI: 1277117; HomoloGene: 20744; GeneCards: PTP4A2; OMA:PTP4A2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	31,944,856 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,743,796 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; palpebral conjunctiva; ; middle frontal gyrus; ; optic nerve; ; external globus pallidus; ; parotid gland; ; medulla oblongata; ; ventral tegmental area;
	Top expressed in
	tail of embryo; ; extensor digitorum longus muscle; ; triceps brachii muscle; ; genital tubercle; ; vastus lateralis muscle; ; plantaris muscle; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; extraocular muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	prenylated protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein binding;
Cellular component	cytoplasm; endosome; plasma membrane; early endosome; membrane; nucleus; cytosol;
Biological process	protein dephosphorylation; dephosphorylation; peptidyl-tyrosine dephosphorylation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	8073
	19244
	ENSG00000184007
	ENSMUSG00000028788
	Q12974
	O70274
NM_001195100; NM_001195101; NM_003479; NM_080391; NM_080392;
	NM_001369858; NM_001369859; NM_001369860
	NM_001164745; NM_008974
NP_001182029; NP_001182030; NP_536316; NP_001356787; NP_001356788;
	NP_001356789
	NP_001158217; NP_033000
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.^[5]^[6]^[7]

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif.

This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.

Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants that encode two distinct isoforms have been described.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184007 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028788 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhao Z, Lee CC, Monckton DG, Yazdani A, Coolbaugh MI, Li X, Bailey J, Shen Y, Caskey CT (Sep 1996). "Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase". Genomics. 35 (1): 172–81. doi:10.1006/geno.1996.0336. PMID 8661118.
^ Zeng Q, Hong W, Tan YH (Apr 1998). "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1". Biochem Biophys Res Commun. 244 (2): 421–7. doi:10.1006/bbrc.1998.8291. PMID 9514946.
^ ^a ^b "Entrez Gene: PTP4A2 protein tyrosine phosphatase type IVA, member 2".