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TNS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DKQ, 2KNO, 2L6K, 2LOZ, 3HQC
Identifiers
Aliases	TNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDs	OMIM: 607717; MGI: 2387586; HomoloGene: 37077; GeneCards: TNS2; OMA:TNS2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,064,379 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,024,836 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastric mucosa; ; tibial nerve; ; canal of the cervix; ; right ovary; ; left uterine tube; ; body of uterus; ; left ovary; ; right lung; ; right lobe of thyroid gland;
	Top expressed in
	ankle joint; ; muscle of thigh; ; tunica media of zone of aorta; ; right lung; ; right lung lobe; ; lip; ; brown adipose tissue; ; myocardium of ventricle; ; ankle; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase binding; phosphoprotein phosphatase activity; protein binding; hydrolase activity; metal ion binding;
Cellular component	cell junction; plasma membrane; intracellular anatomical structure; membrane; focal adhesion;
Biological process	protein dephosphorylation; collagen metabolic process; intracellular signal transduction; multicellular organismal homeostasis; response to muscle activity; cellular homeostasis; kidney development; negative regulation of cell population proliferation; multicellular organism growth;
	Sources:Amigo / QuickGO
Orthologs
	23371
	209039
	ENSG00000111077
	ENSMUSG00000037003
	Q63HR2
	Q8CGB6
	NM_015319; NM_170754; NM_198316
	NM_153533; NM_001355636
	NP_056134; NP_736610; NP_938072
	NP_705761; NP_001342565
	Wikidata
View/Edit Human	View/Edit Mouse

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.^[5]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.^[5]

Interactions

TENC1 has been shown to interact with AXL receptor tyrosine kinase.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111077 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037003 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)".
^ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5). United States: 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648.