NPR1

NPR1
Identifiers
Aliases	NPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDs	OMIM: 108960; MGI: 97371; HomoloGene: 37367; GeneCards: NPR1; OMA:NPR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,693,992 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,373,173 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right uterine tube; ; gastric mucosa; ; left uterine tube; ; right coronary artery; ; left coronary artery; ; subcutaneous adipose tissue; ; right lung; ; triceps brachii muscle;
	Top expressed in
	yolk sac; ; spermatocyte; ; muscle of thigh; ; blastocyst; ; morula; ; adrenal gland; ; lip; ; esophagus; ; thyroid gland; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; nucleotide binding; G protein-coupled peptide receptor activity; hormone binding; guanylate cyclase activity; GTP binding; lyase activity; natriuretic peptide receptor activity; phosphorus-oxygen lyase activity; ATP binding; peptide hormone binding; adenylate cyclase activity; protein kinase binding; peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; receptor complex; guanylate cyclase complex, soluble; intracellular anatomical structure;
Biological process	negative regulation of smooth muscle cell proliferation; regulation of cardiac conduction; intracellular signal transduction; positive regulation of renal sodium excretion; positive regulation of urine volume; body fluid secretion; cyclic nucleotide biosynthetic process; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; cGMP biosynthetic process; protein phosphorylation; cell surface receptor signaling pathway; regulation of vascular permeability; dopamine metabolic process; negative regulation of cell growth; negative regulation of angiogenesis; G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; positive regulation of cGMP-mediated signaling; cGMP-mediated signaling; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4881
	18160
	ENSG00000169418
	ENSMUSG00000027931
	P16066
	P18293
	NM_000906
	NM_008727
	NP_000897
	NP_032753
	Wikidata
View/Edit Human	View/Edit Mouse

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).^[5]

It is localized in the kidney^[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.^[6]