EPHB6

EPHB6
Identifiers
AliasesEPHB6, HEP, EPH receptor B6
External IDsOMIM: 602757; MGI: 1096338; HomoloGene: 20940; GeneCards: EPHB6; OMA:EPHB6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2051

13848

Ensembl

ENSG00000106123
ENSG00000275482

ENSMUSG00000029869

UniProt

O15197

O08644

RefSeq (mRNA)

NM_001280794
NM_001280795
NM_004445

NM_001146351
NM_007680

RefSeq (protein)

NP_001267723
NP_001267724
NP_004436

NP_001139823
NP_031706

Location (UCSC)Chr 7: 142.86 – 142.87 MbChr 6: 41.58 – 41.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.[5]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.[5]

References

  1. ^ a b c ENSG00000275482 GRCh38: Ensembl release 89: ENSG00000106123, ENSG00000275482 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029869 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: EPHB6 EPH receptor B6".

Further reading


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