3P1I, 3ZFY
2049
13845
ENSG00000182580
ENSMUSG00000005958
P54753
P54754
NM_004443
NM_010143
NP_004434
NP_034273
Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.[5][6]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[6]
EPHB3 has been shown to interact with MLLT4[7] and RAS p21 protein activator 1.[8]
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
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