PROFILPELAJAR.COM

EPHB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P1I, 3ZFY
Identifiers
Aliases	EPHB3, ETK2, HEK2, TYRO6, EPH receptor B3, EK2
External IDs	OMIM: 601839; MGI: 104770; HomoloGene: 20938; GeneCards: EPHB3; OMA:EPHB3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,582,408 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	21,042,055 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; skin of leg; ; skin of abdomen; ; gingival epithelium; ; parotid gland; ; mucosa of transverse colon; ; periodontal fiber; ; skin of arm; ; hair follicle; ; rectum;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; lip; ; tongue; ; corneal stroma; ; molar; ; skin of abdomen; ; esophagus; ; calvaria;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; kinase activity; ATP binding; transferase activity; ephrin receptor activity; axon guidance receptor activity; protein tyrosine kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity; transmembrane-ephrin receptor activity;
Cellular component	extracellular region; dendrite; integral component of membrane; cell projection; membrane; cytosol; plasma membrane; integral component of plasma membrane; cytoplasm; neuron projection; receptor complex;
Biological process	phosphorylation; peptidyl-tyrosine phosphorylation; nervous system development; multicellular organism development; regulation of cell-cell adhesion; protein phosphorylation; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of GTPase activity; protein autophosphorylation; angiogenesis; ephrin receptor signaling pathway; urogenital system development; axon guidance; axonal fasciculation; cell migration; central nervous system projection neuron axonogenesis; corpus callosum development; retinal ganglion cell axon guidance; thymus development; digestive tract morphogenesis; regulation of axonogenesis; positive regulation of synapse assembly; roof of mouth development; dendritic spine development; dendritic spine morphogenesis; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	2049
	13845
	ENSG00000182580
	ENSMUSG00000005958
	P54753
	P54754
	NM_004443
	NM_010143
	NP_004434
	NP_034273
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.^[5]^[6]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[6]

Interactions

EPHB3 has been shown to interact with MLLT4^[7] and RAS p21 protein activator 1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182580 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005958 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rübsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene. 8 (10): 2857–62. PMID 8397371.
^ ^a ^b "Entrez Gene: EPHB3 EPH receptor B3".
^ Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
^ Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene. 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711.

External links

Overview of all the structural information available in the PDB for UniProt: P54753 (Ephrin type-B receptor 3) at the PDBe-KB.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182580 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005958 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8397371-5] Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rübsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene. 8 (10): 2857–62. PMID 8397371.

[entrez-6] "Entrez Gene: EPHB3 EPH receptor B3".

[pmid9707552-7] Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.

[pmid9674711-8] Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene. 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

PROFILPELAJAR.COM

EPHB3

Function

Interactions

References

Further reading

External links

Read other articles:

Hollywood Sign

Batuk anjing

WOTF-TV

Royal Treasure

Larrabee (microarchitecture)

Post-transcriptional modification

Darul Uloom Nadwatul Ulama

KQLV (FM)

Daryal radar

國際調查記者同盟

Île Wolfe

Berkain

Iraqi map pendant

ESPN

Cola di Rienzo

Trolleybus

Ševětín

Fawzi al-Qawuqji

水素化アルミニウム

Cesare Casirago