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Fluorometholone
Clinical data
Other names	(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.com	Monograph
MedlinePlus	a682660
ATC code	C05AA06 (WHO) D07AB06 (WHO), D07XB04 (WHO) (combinations), D10AA01 (WHO), S01BA07 (WHO);
Legal status
Legal status	CA: ℞-only;
Identifiers
	IUPAC name (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one;
CAS Number	426-13-1 ;
PubChem CID	9878;
IUPHAR/BPS	7079;
DrugBank	DB00324 ;
ChemSpider	9494 ;
UNII	SV0CSG527L;
KEGG	D01367 ;
ChEBI	CHEBI:31625 ;
ChEMBL	ChEMBL1200600 ;
CompTox Dashboard (EPA)	DTXSID7047435 ;
ECHA InfoCard	100.006.402
Chemical and physical data
Formula	C22H29FO4
Molar mass	376.468 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C;
	InChI InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 ; Key:FAOZLTXFLGPHNG-KNAQIMQKSA-N ;
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Fluorometholone (INN, BAN, JAN) (brand names Efflumidex, Flucon, FML Forte, FML, others), also known as 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases.^[2]^[3]^[4] The C17α acetate ester, fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications.^[2]^[3]^[4]

References

^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
^ ^a ^b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 566–. ISBN 978-1-4757-2085-3.
^ ^a ^b Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 458–. ISBN 978-3-88763-075-1.
^ ^a ^b Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 123–. ISBN 978-94-011-4439-1.

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[1] "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.

[Elks2014-2] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 566–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-3] Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 458–. ISBN 978-3-88763-075-1.

[MortonHall2012-4] Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 123–. ISBN 978-94-011-4439-1.

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