Ro 6-3129

Ro 6-3129
Clinical data

Other names	16α-Ethylthiodydrogesterone; 16α-Ethylthio-6-dehydroretroprogesterone; 16α-Ethylthio-9β,10α-pregna-4,6-diene-3,20-dione
Routes of administration	Oral
Identifiers
IUPAC name (1R,2S,10S,11S,13R,14S,15S)-14-Acetyl-13-(ethylsulfanyl)-2,15-dimethyltetracyclo[8.7.0.0^2,7.0^11,15]heptadeca-6,8-dien-5-one
CAS Number	39729-35-6
ChemSpider	59650717
Chemical and physical data
Formula	C₂₃H₃₂O₂S
Molar mass	372.57 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCS[C@@H]1C[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]2(C)[C@H]1C(C)=O
InChI InChI=1S/C23H32O2S/c1-5-26-20-13-19-17-7-6-15-12-16(25)8-10-22(15,3)18(17)9-11-23(19,4)21(20)14(2)24/h6-7,12,17-21H,5,8-11,13H2,1-4H3/t17-,18-,19+,20-,21+,22-,23?/m1/s1 Key:OWNPEOXTHUGQDI-LWAHLCLDSA-N

Ro 6-3129, also known as 16α-ethylthio-6-dehydroretroprogesterone or as 16α-ethylthio-9β,10α-pregna-4,6-diene-3,20-dione, as well as 16α-ethylthiodydrogesterone, is a progestogen of the retroprogesterone group which was developed by Roche but was never marketed.^[1]^[2]^[3] It shows greater potency than dydrogesterone in bioassays.^[4]

References

^ Harper MJ (1977). "Contraception — retrospect and prospect". In Jucker E (ed.). Progress in Drug Research. Vol. 21. pp. 293–407 [321]. doi:10.1007/978-3-0348-7098-6_4. ISBN 978-3-0348-7098-6. PMID 339271.
^ Larsson-Cohn U, Johansson ED, Wide L, Gemzell C (September 1970). "Effects of daily administration of a retrosteroid on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens". The Journal of Obstetrics and Gynaecology of the British Commonwealth. 77 (9): 840–846. doi:10.1111/j.1471-0528.1970.tb04411.x. PMID 5458777. S2CID 6176278.
^ Dixon R, Hudson S, Darragh A (1973). "Pharmacokinetics of the retro-steroid progestogen, 16α-ethylthio-9β,10α-pregna-4, 6-diene-3, 20-dione (Ro 6-3129), in man and the sheep". Contraception. 8 (1): 53–65. doi:10.1016/0010-7824(73)90159-5. ISSN 0010-7824.
^ The Journal of Obstetrics and Gynaecology of the British Commonwealth. Royal College of Obstetricians and Gynaecologists. 1970.

Progesterone receptor modulators

Agonists	Progesterone derivatives: 3β-Dihydroprogesterone 5α-Dihydroprogesterone 6α-Methylprogesterone 9α-Bromo-11-ketoprogesterone 11-Dehydroprogesterone 11-Deoxycorticosterone 16α-Hydroxyprogesterone 17α-Methyl-11-deoxycorticosterone acetate 20α-Dihydroprogesterone 20β-Dihydroprogesterone Dimepregnen Diosgenin P1-185 Progesterone Progesterone 3-acetyl enol ether Quingestrone Retroprogesterone derivatives: 20α-Dihydrodydrogesterone 20α-Dihydrotrengestone DU-41164 DU-41165 Dydrogesterone Retroprogesterone Ro 6-3129 Trengestone 17α-Substituted progesterone derivatives: 6α-Methyl-17α-bromoprogesterone 15β-Hydroxycyproterone acetate 16-Methylene-17α-hydroxyprogesterone acetate 17α-Bromoprogesterone 17α-Hydroxyprogesterone (hydroxyprogesterone) 17α-Methylprogesterone Acetomepregenol (mepregenol diacetate) Algestone Algestone acetonide Algestone acetophenide Anagestone Anagestone acetate Bromethenmadinone Bromethenmadinone acetate Butagest (buterol) Chlormadinone Chlormadinone acetate Chlormadinone caproate Chlormethenmadinone Chlormethenmadinone acetate Cismadinone Cismadinone acetate Clogestone Clogestone acetate Clomegestone Clomegestone acetate Cymegesolate Cyproterone acetate Delmadinone Delmadinone acetate Edogestrone Flugestone Flugestone acetate Fluorometholone Fluorometholone acetate Flumedroxone Flumedroxone acetate Fluoromedroxyprogesterone acetate Gestaclone Gestobutanoyl Haloprogesterone Hydromadinone Hydromadinone acetate Hydroxyprogesterone acetate Hydroxyprogesterone caproate (hydroxyprogesterone hexanoate) Hydroxyprogesterone heptanoate (hydroxyprogesterone enanthate) Hydroxyprogesterone heptanoate benzilic acid hydrazone Mecigestone (pentarane B) Medrogestone Medroxyprogesterone Medroxyprogesterone acetate Medroxyprogesterone caproate Megestrol Megestrol acetate Megestrol caproate Melengestrol Melengestrol acetate Methenmadinone Methenmadinone acetate Methenmadinone caproate Mometasone Mometasone furoate Osaterone Osaterone acetate Pentagestrone Pentagestrone acetate Pentarane A Proligestone Triamcinolone acetonide 19-Norprogesterone derivatives: 17α-Methyl-19-norprogesterone 18-Methylsegesterone acetate 19-Norprogesterone Amadinone Amadinone acetate Demegestone Fluoro ethyl norprogesterone Fluoro furanyl norprogesterone Gestadienol Gestadienol acetate Gestonorone acetate (gestronol acetate) Gestonorone caproate (gestronol hexanoate) Gestronol (gestonorone) Nomegestrol Nomegestrol acetate Norgestomet ORG-2058 Oxogestone Oxogestone phenpropionate (xinogestone) Promegestone Segesterone Segesterone acetate (nestorone) Trimegestone Testosterone derivatives: Progestins: 6,6-Difluoronorethisterone 6,6-Difluoronorethisterone acetate 17α-Allyl-19-nortestosterone Allylestrenol Altrenogest Chloroethynylnorgestrel Cingestol Danazol Desogestrel Dienogest Ethinylandrostenediol Ethandrostate Ethisterone Ethynerone Etonogestrel Etynodiol Etynodiol diacetate Gestodene Gestrinone Levonorgestrel Levonorgestrel esters (e.g., levonorgestrel butanoate) Lynestrenol Lynestrenol phenylpropionate Metynodiol Metynodiol diacetate Norelgestromin Norethisterone (norethindrone) Norethisterone esters (e.g., norethisterone acetate, norethisterone enanthate) Noretynodrel Norgesterone Norgestimate Norgestrel Norgestrienone Norvinisterone Oxendolone Quingestanol Quingestanol acetate Tibolone Tigestol Tosagestin; Anabolic–androgenic steroids: 11β-Methyl-19-nortestosterone 11β-Methyl-19-nortestosterone dodecylcarbonate 19-Nor-5-androstenediol 19-Nor-5-androstenedione 19-Nordehydroepiandrosterone Bolandiol Bolandiol dipropionate Bolandione Dimethisterone Dienedione Dienolone Dimethandrolone Dimethandrolone buciclate Dimethandrolone dodecylcarbonate Dimethandrolone undecanoate Dimethyldienolone Dimethyltrienolone Ethyldienolone Ethylestrenol (ethylnandrol) Methyldienolone Metribolone (R-1881) Methoxydienone (methoxygonadiene) Mibolerone Nandrolone Nandrolone esters (e.g., nandrolone decanoate, nandrolone phenylpropionate) Norethandrolone Normethandrone (methylestrenolone, normethandrolone, normethisterone) RU-2309 Tetrahydrogestrinone Trenbolone (trienolone) Trenbolone esters (e.g., trenbolone acetate, trenbolone enanthate) Trendione Trestolone Trestolone acetate Spirolactone derivatives: Canrenoic acid Canrenone Drospirenone Mespirenone Potassium canrenoate Prorenone SC-5233 (spirolactone) SC-8109 Spironolactone Spirorenone Nonsteroidal: 3,8-Dihydrodiligustilide LG-2527 LG-100128 Riligustilide RWJ-26819 RWJ-49853 RWJ-60130 Tanaproget ZM-182345 Unknown: ORG-47241 ORG-201745
Mixed (SPRMsTooltip Selective progesterone receptor modulators)	Steroidal: Dihydroethisterone 5α-Dihydrolevonorgestrel 5α-Dihydronorethisterone Asoprisnil Asoprisnil ecamate Guggulsterone J1042 LG-120838 Metapristone (RU-42633) Mifepristone (RU-486) ORF-9371 ORF-9326 ORG-31710 ORG-33628 RMI-12936 Telapristone Ulipristal acetate Vilaprisan ZK-137316 Nonsteroidal: Apigenin Kaempferol LG-120920 Naringenin PRA-910 Syringic acid
Antagonists	Steroidal: Aglepristone Lilopristone Lonaprisan Onapristone ORG-31710 ORG-31806 ORG-33628 RTI 3021–022 Toripristone Zanoterone Nonsteroidal: Darolutamide LG-001447 LG-100127 LG-100128 LG-120830 LG-121046 Valproic acid ZM-150271 ZM-172406

mPR
(PAQR)

Agonists	5α-Dihydroprogesterone 5β-Dihydroprogesterone 11-Deoxycortisone (21-hydroxyprogesterone) 11-Deoxycortisol (17α,21-dihydroxyprogesterone) 17α-Hydroxyprogesterone Allopregnanolone Mifepristone Pregnenolone Progesterone
Antagonists	Mifepristone

See also: Receptor/signaling modulators; Progestogens and antiprogestogens; Androgen receptor modulators; Estrogen receptor modulators; List of progestogens

This article about a steroid is a stub. You can help Wikipedia by expanding it.

This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.

Read other articles:

D'Terong Show

D'Terong ShowPoster digital D'Terong Show Musim 2PembuatProgramming IndosiarPresenterRamziRina NoseIrfan HakimEdric TjandraJuriInul Daratista (2014 - 2015)Saipul Jamil (2014 - 2015)Beniqno (2014 - 2015)Iis Dahlia (2014)Yannus Sufandi (2015)Nassar (2014)Soimah (2015)Ivan Gunawan (2014 - 2015)Negara asalIndonesiaJmlh. musim2Jmlh. episode232Rilis asliJaringanIndosiarFormat audioStereoRilis15 Maret 2014 –27 April 2015 D'Terong Show (digayakan sebagai D'T3rong Show) adalah suatu acara ...

Gagang-bayam hitam

Gagang-bayam hitam Himantopus novaezelandiae Wild kakī in Lake TekapoStatus konservasiTerancam kritisIUCN22693690 TaksonomiKerajaanAnimaliaFilumChordataKelasAvesOrdoCharadriiformesFamiliRecurvirostridaeGenusHimantopusSpesiesHimantopus novaezelandiae Gould, 1841 Distribusi EndemikSelandia Baru lbs Gagang-bayam hitam ( Himantopus novaezelandiae ) atau kakī ( Māori ) adalah burung perandai yang ditemukan di Selandia Baru. Ini adalah salah satu burung paling langka di dunia, dengan 169 burung ...

Bearsden

Bearsden bahasa Gaelik Skotlandia: Cille Phàdraig Ùr Scots: Easter Kirkpatrick, Eister Kilpatrickcode: sco is deprecated Lambang kebesaran Burgh Bearsden, 1959–75. Population Expression error: Templat:Scottish locality populations must be numeric (2011 est.)[1] Ref. grid OS NS542720 Wilayah keletnanan Dunbartonshire Negara konstituen Skotlandia Negara berdaulat Britania Raya Kota pos GLASGOW[2] Distrik kode pos G61 Kode tel...

Katrín Jakobsdóttir

Prime Minister of Iceland since 2017 This is an Icelandic name. The last name is patronymic, not a family name; this person is referred to by the given name Katrín. Her ExcellencyKatrín JakobsdóttirKatrín in 202328th Prime Minister of IcelandOutgoingAssumed office 30 November 2017PresidentGuðni Th. JóhannessonPreceded byBjarni BenediktssonChair of the Left-Green MovementIn office24 February 2013 – 5 April 2024Preceded bySteingrímur J. SigfússonSucceeded byGuðmundur...

Arthur Stone (actor)

American actor (1883–1940) Arthur StoneStone in 1924BornArthur Taylor Goetze(1883-11-28)November 28, 1883St. Louis, Missouri, U.S.DiedSeptember 4, 1940(1940-09-04) (aged 56)Hollywood, California, U.S.Resting placeForest Lawn Memorial Park, Glendale, CaliforniaOccupationActorYears active1924–1938SpouseDorothy Westmore Arthur Stone (born Arthur Taylor Goetze; November 28, 1883 – September 4, 1940) was an American character actor of the late silent and early sound film eras. Biog...

Desmond Miles

Assassin's Creed character This article may need to be rewritten to comply with Wikipedia's quality standards. You can help. The talk page may contain suggestions. (April 2024) Fictional character Desmond MilesAssassin's Creed characterDesmond Miles in Assassin's Creed: BrotherhoodFirst gameAssassin's Creed (2007)Created byUbisoft MontrealVoiced byNolan NorthMotion captureFrancisco RandezIn-universe informationAliasThe ReaderOriginBlack Hills, South Dakota, United StatesNationalityAmerican De...

ロバート・デ・ニーロ

ロバート・デ・ニーロRobert De Niro 2011年のデ・ニーロ生年月日 (1943-08-17) 1943年8月17日（80歳）出生地アメリカ合衆国・ニューヨーク州ニューヨーク市身長 177 cm職業俳優、映画監督、映画プロデューサージャンル映画、テレビドラマ活動期間 1963年 -配偶者ダイアン・アボット（1976年 - 1988年）グレイス・ハイタワー（1997年 - ）主な作品『ミーン・ストリート』（1973年）...

France Télévisions

France Télévisions S.A.JenisSociété anonymeDidirikan2000KantorpusatFrance Télévisions SA7, esplanade Henri de France 75015 ParisTokohkunciPatrick de Carolis: Chief Executive OfficerPatrice Duhamel : Wakil Presiden dan Direktur Jenderal Penyiaran.Pendapatan2,727 juta EURPemilikPemerintah PrancisKaryawan11,400Situs webwww.france.tv France Télévisions merupakan penyiar televisi nasional umum Prancis. Didanai oleh lisensi televisi dan periklanan. Sejarah Sejak tahun 1964 sampai 1974,...

Oscar Griffin Jr.

American journalist (1933–2011) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Oscar Griffin Jr. – news · newspapers · books · scholar · JSTOR (May 2019) (Learn how and when to remove this message) Oscar Griffin Jr.BornOscar O'Neal Griffin Jr.(1933-04-28)April 28, 1933Daisetta, Texas, U.S.DiedNovember 23,...

Vouneuil-sur-Vienne

Vouneuil-sur-ViennecomuneVouneuil-sur-Vienne – Veduta LocalizzazioneStato Francia Regione Nuova Aquitania Dipartimento Vienne ArrondissementChâtellerault CantoneChauvigny TerritorioCoordinate46°43′N 0°32′E / 46.716667°N 0.533333°E46.716667; 0.533333 (Vouneuil-sur-Vienne)Coordinate: 46°43′N 0°32′E / 46.716667°N 0.533333°E46.716667; 0.533333 (Vouneuil-sur-Vienne) Superficie36,5 km² Abitanti2 036[1] (2009) De...

Techint

TechintTechint's Rome headquartersCompany typePrivateIndustrySteel, Mining, Constructions, Engineering, HealthcareFounded1945; 79 years ago (1945)FounderAgostino RoccaHeadquartersBuenos Aires MilanKey peopleGianfelice RoccaPaolo RoccaProductsFlat-rolled steel, tubular steel, industrial machinery, public infrastructure, oil & gas, mining, energy, health servicesRevenue US$ 25.477 billion (2012)[1]Number of employees59,196 (2012)[1]Divisions Tenaris Ternium...

哥伦布 (密西西比州)

密西西比州哥伦布城市綽號：Possum Town哥伦布位于密西西比州的位置坐标：33°30′06″N 88°24′54″W / 33.501666666667°N 88.415°W / 33.501666666667; -88.415国家美國州密西西比州县朗兹县始建于1821年政府 • 市长罗伯特·史密斯 (民主党)面积 • 总计22.3 平方英里（57.8 平方公里） • 陸地21.4 平方英里（55.5 平方公里） • ...

Miguel Algarín

Puerto Rican poet (1941–2020) Miguel Algarín Jr.Miguel Algarín Jr.Born(1941-09-11)11 September 1941Santurce, San Juan, Puerto RicoDied30 November 2020(2020-11-30) (aged 79)New York City, U.S.OccupationPoetscholareditorplaywrighttranslatorNationalityPuerto RicanEducationUniversity of Wisconsin–MadisonPennsylvania State UniversityRutgers UniversityLiterary movementNuyoricanNotable awardsAmerican Book Award (1980, 1985, 1994)Larry Leon Hamlin Producer's AwardAmerican Book Award for Li...

Apuleius

2nd-century Numidian Latin-language writer, rhetorician and philosopher Not to be confused with Lucius Appuleius Saturninus, a Roman demagogue, or others with the name Apuleius or Appuleius. ApuleiusLate antique ceiling painting c. 330, possibly of ApuleiusBornc. 124Madaurus, NumidiaDiedc. 170 (aged 45–46)Occupation(s)Novelist, writer, public speakerNotable workThe Golden AssSchoolMiddle Platonism Apuleius (/ˌæpjʊˈliːəs/, APP-yuu-LEE-əs; also called Lucius Apuleius Mad...

Mole (animal)

Small subterranean mammal This article is about the mammals called moles. For other uses, see Mole (disambiguation). Not to be confused with vole, a small mouse-like rodent. A European moleVarious moles Moles are small mammals adapted to a subterranean lifestyle. They have cylindrical bodies, velvety fur, very small, inconspicuous eyes and ears,[1] reduced hindlimbs, and short, powerful forelimbs with large paws adapted for digging. The word mole refers to any species in the family Ta...

دونالد مورلي

هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (أبريل 2019) دونالد مورلي معلومات شخصية الميلاد 7 أكتوبر 1930 الوفاة 23 يونيو 2006 (75 سنة) مواطنة المملكة المتحدة الحياة العملية المهنة سائق رالي اللغات الإن�...

Micronova

Explosive stellar phenomenon about one millionth the strength of a classical nova This article is about the astronomical event. For the microprocessor, see Data General Nova § microNOVA. Artist's impression of a micronovaA micronova is a putative type of thermonuclear explosion on the surface of a white dwarf much smaller than the strength of a nova; being about 1×1039 ergs (1.0×10−12 foe; 1.0×1032 J) in strength, about a millionth that of a typical nova. The phenomenon w...

Alfiz

The alfiz (Spanish: [alˈfiθ], from Andalusi Arabic الحِيْز alḥíz, from Standard Arabic الحَيِّز alḥáyyiz, meaning 'the container';[1]) is an architectural adornment, consisting of a moulding, usually a rectangular panel, which encloses the outward side of an arch. It is an architectonic ornament of Etruscan origin, used in Visigothic, Asturian, Moorish, Mozarabic, Mudéjar and Isabelline Gothic architecture. Types of Alfiz. It is frequent in the Islamic ...

Sultanato di Malwa

Sultanato di Malwaمالوہ سلطنتSultanato di Malwaمالوہ سلطنت - LocalizzazioneStati indiani nel XV secolo, tra cui il Sultanato di Malwa (a E del Gujarat. Dati amministrativiCapitaleDhar, poi Mandu PoliticaForma di governoSultanato SultanoVedi i sultani Nascita1392 Fine1561/2 con Baz Bahadur Territorio e popolazioneReligione e societàReligione di StatoIslam sunnita Evoluzione storicaPreceduto da Sultanato di Delhi Succeduto da Sultanato di GujaratMoghul Ora parte di Ind...

Thooval Kottaram

1996 Indian filmThooval KottaramPromotional posterDirected bySathyan AnthikadWritten byA. K. LohithadasProduced byGrihalakshmi ProductionsStarringJayaram DileepCinematographyVipin MohanEdited byK. RajagopalMusic byJohnsonProductioncompanyGrihalakshmi ProductionsDistributed byKalpaka FilmsRelease date 23 August 1996 (1996-08-23) Running time150 minutesCountryIndiaLanguageMalayalam Thooval Kottaram (transl. Feather Palace) is a 1996 Indian Malayalam-language romantic dram...