17α-Bromoprogesterone

17α-Bromoprogesterone
Clinical data
Other names17α-BP; 17α-Bromopregn-4-ene-3,20-dione
Drug classProgestogen; Progestin
Identifiers
  • (8R,9S,10R,13S,14S,17R)-17-Acetyl-17-bromo-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC21H29BrO2
Molar mass393.365 g·mol−1
3D model (JSmol)
  • CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)Br
  • InChI=1S/C21H29BrO2/c1-13(23)21(22)11-8-18-16-5-4-14-12-15(24)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
  • Key:IENASMFTJRLBJP-CEGNMAFCSA-N

17α-Bromoprogesterone (17α-BP) is a progestin which was first described in 1957 and was never marketed.[1][2][3][4] It is about twice as potent as progesterone in terms of progestogenic activity in animal bioassays.[1] 17α-BP is a parent compound of haloprogesterone (6α-fluoro-17α-bromoprogesterone) and 6α-methyl-17α-bromoprogesterone.[5]

See also

References

  1. ^ a b Engel CR, Jahnke H (November 1957). "Steroids and related products. X. 17 alpha-Bromoprogesterone, a new potent gestogen". Canadian Journal of Biochemistry and Physiology. 35 (11): 1047–1055. doi:10.1139/o57-120. PMID 13479803.
  2. ^ Seeley DH, Wang WY, Salhanick HA (November 1982). "Molecular interactions of progesterone analogues with rabbit uterine cytoplasmic receptor". The Journal of Biological Chemistry. 257 (22): 13359–13366. doi:10.1016/S0021-9258(18)33456-2. PMID 7142152.
  3. ^ Bohl M, Simon Z, Vlad A, Kaufmann G, Ponsold K (1987). "MTD calculations on quantitative structure-activity relationships of steroids binding to the progesterone receptor". Zeitschrift für Naturforschung C. 42 (7–8): 935–940. doi:10.1515/znc-1987-7-834. PMID 2961153. S2CID 22962904.
  4. ^ Simon Z, Bohl M (1992). "Structure-activity Relations in Gestagenic Steroids by the MTD Method. The Case of Hard Molecules and Soft Receptors". Quantitative Structure-Activity Relationships. 11 (1): 23–28. doi:10.1002/qsar.19920110104. ISSN 0931-8771.
  5. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 179, 620. ISBN 978-1-4757-2085-3.
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