Chloroxine

Chloroxine
Clinical data
Trade namesCapitrol
Other namescloroxinum, kloroxin, chlorquinol, dichlorchinolinolum, halquinol(s)
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.011.144 Edit this at Wikidata
Chemical and physical data
FormulaC9H5Cl2NO
Molar mass214.05 g·mol−1
3D model (JSmol)
  • Clc1c(O)c2ncccc2c(Cl)c1
  • InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
  • Key:WDFKMLRRRCGAKS-UHFFFAOYSA-N
Not to be confused with Chloroquine.

Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s));[citation needed] Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug.[1] Oral formulations (under trade name such as Endiaron[2]) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis.,[3] as used in shampoos (Capitrol) and dermal creams like (Valpeda, Triaderm).

Mechanism of action

Chloroxine has bacteriostatic, fungistatic, and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella, and Trichomonads.[citation needed]

Adverse effects

Rarely occurs, but may cause nausea and vomiting associated with oral administration. It may also cause skin irritation.[citation needed]

Pregnancy and lactation

The FDA lists chloroxine in Pregnancy Category C (risk cannot be ruled out) because no pregnancy studies on the medication have been performed with animals or humans. For this reason, use of chloroxine oral or topical during pregnancy or when breast-feeding is not recommended.[4]

History

Chloroxine was first prepared in 1888 by A. Hebebrand.[citation needed]

References

  1. ^ Pharmaceutical Manufacturing, Books.Google.com
  2. ^ Endiaron.cz
  3. ^ Chloroxine, drugs.com
  4. ^ Capitrol - FDA prescribing information Archived 2018-11-24 at the Wayback Machine, drugs.com

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