3ZQS, 4CCG
55120
67030
ENSG00000115392
ENSMUSG00000004018
Q9NW38
Q9CR14
NM_001114636NM_018062NM_001374615
NM_001277273NM_025923
NP_001108108NP_060532NP_001361544
NP_001264202NP_080199
E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.[5]
The clinical phenotype of mutational defects in all Fanconi anemia (FA) complementation groups is similar. This phenotype is characterized by progressive bone marrow failure, cancer proneness and typical birth defects.[13] The main cellular phenotype is hypersensitivity to DNA damage, particularly inter-strand DNA crosslinks.[14] The FA proteins interact through a multi-protein pathway. DNA interstrand crosslinks are highly deleterious damages that are repaired by homologous recombination involving coordination of FA proteins and breast cancer susceptibility gene 1 (BRCA1).
The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). A critical step in the pathway is the monoubiquitination of FANCD2 by the RING E3 ligase FANCL. FANCL comprises 3 domains, a RING domain that interacts with E2 conjugating enzymes, a central domain required for substrate interaction, and an N-terminal E2-like fold (ELF) domain that interacts with FANCB.[15] The ELF domain of FANCL is also required to mediate a non-covalent interaction between FANCL and ubiquitin. The ELF domain is required to promote efficient DNA damage-induced FANCD2 monoubiquitination in vertebrate cells, suggesting an important function of FANCB and ubiquitin binding by FANCL in vivo.[16]
A nuclear complex containing FANCL (as well as FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCM) is essential for the activation of the FANCD2 protein to the mono-ubiquitinated isoform.[6] In normal, non-mutant, cells FANCD2 is mono-ubiquinated in response to DNA damage. Activated FANCD2 protein co-localizes with BRCA1 (breast cancer susceptibility protein) at ionizing radiation-induced foci and in synaptonemal complexes of meiotic chromosomes (see Figure: Recombinational repair of double strand damage).
село Слобідка-Гуменецька Костел Святого Івана ХрестителяКостел Святого Івана Хрестителя Країна Україна Область Хмельницька область Район Кам'янець-Подільський район Громада Гуменецька сільська громада Основні дані Засноване 1851 Населення 713 Площа 0,788 км² Густота
XQD Тип носія Карта пам'ятіЄмність До 240 ГБРозроблено CompactFlash AssociationРозміри 38.5 mm × 29.8 mm × 3.8 mmЗастосування Цифрові камери XQD-картрідер Sony XQD — формат карт пам'яті, призначений для особливо вимогливих до швидкості читання і запису пристроїв обробки цифрових даних.
لمعانٍ أخرى، طالع أديب (توضيح). هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (مارس 2016) أديب أديب اللفظ أديب الجنس ذكر لغة الاسم لغة عربية، لغة فارسية أصل الاسم الأصل اللغوي عربي المعنى حسن الأخلاق المنطقة العا…
Sculpture above the fireplace created by Romanian sculptor George Julian Zolnay. The Katy Hamman-Stricker Library is located at 404 E. Mitchell Street in Calvert, Texas, USA.[1] It consists of a museum as well as a public library and community center and was the first chapter house built by the American Woman's League in the state. Calvert is located within the Golden Triangle (the area between the cities of Dallas, Houston and Austin) of Texas. The building was constructed in 1909 but i…
General shape of a human body This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Body shape – news · newspapers · books · scholar · JSTOR (August 2015) (Learn how and when to remove this template message) Line art depiction of nude man and woman from the Pioneer plaques. Women typically have wider hips than should…
В Википедии есть статьи о других людях с такой фамилией, см. Абдуллаев. Муслим Абдуллаев Личная информация Пол мужской Полное имя Муслим Кайсарович Абдуллаев Дата рождения 1982(1982) Место рождения Батаюрт, Хасавюртовский район, Дагестанская АССР, РСФСР, СССР Дата смерти 24 дек…
American record producer and rapper (born 1965) Doctor Dre and Andre Young redirect here. For the rapper and MTV VJ, see Doctor Dré. For other uses, see Andre Young (disambiguation). Dr. DreDr. Dre in 2013BornAndre Romell Young (1965-02-18) February 18, 1965 (age 58)Compton, California, U.S.Other namesDreBrickhardThe MechanicEducation Centennial High School John C. Fremont High School OccupationsRecord producerrapperactorentrepreneurrecord executiveYears active1985–presentWorks…
Capital city of Saxony, Germany For other uses, see Dresden (disambiguation). City in Saxony, GermanyDresden City Clockwise: Dresden skyline with River Elbe at dusk, Semper Opera, Catholic Court Church, Academy of Fine Arts with lemon squeezer dome and sculpture of Pheme, Dresden skyline, Dresden Castle, rebuilt houses on New Market Square with statue of Frederick Augustus II of Saxony, Our Lady's Church at dusk FlagCoat of armsLocation of Dresden Dresden Show map of GermanyDresden Show map of S…
Este artículo o sección necesita referencias que aparezcan en una publicación acreditada.Este aviso fue puesto el 6 de mayo de 2020. Universidad Nacional de EducaciónEnrique Guzmán y Valle Escudo de la UNE Vista de la entrada de la UNE.Sigla UNE EGyV, UNE.Lema Alma Máter del Magisterio NacionalTipo Universidad públicaFundación 6 de julio de 1822 (201 años)Fundador José de San Martín LocalizaciónDirección (Av. Enrique Guzmán y Valle Nº 951, , Chosica )Lima, Perú PerúCampus C…
Data management web service Google Fusion TablesScreenshot of Google Fusion Tables.Type of site Data management Data visualization Web service Web mapping Created byGoogleURLgoogle.com/fusiontablesRegistrationOptional, included with a Google AccountLaunched9 June 2009; 14 years ago (2009-06-09)Current statusDiscontinued on 3 December 2019; 4 years ago (2019-12-03) Google Fusion Tables was a web service provided by Google for data management. Fusion t…
Academy Awards ke-58Poster resmiTanggal24 Maret 1986TempatDorothy Chandler PavilionLos Angeles, California, U.S.Pembawa acaraAlan AldaJane FondaRobin WilliamsProduserStanley DonenPengarah acaraMarty PasettaSorotanFilm TerbaikOut of AfricaPenghargaan terbanyakOut of Africa (7)Nominasi terbanyakThe Color Purple and Out of Africa (11)Liputan televisiJaringanABCDurasi3 jam, 11 menit[1] ← ke-57 Academy Awards ke-59 → Acara Academy Awards ke-58, yang diadakan oleh Academy…
Queen consort of Egypt Maatkare BQueen consort of EgyptStatue of the High Priest of Amun Shoshenq, mentioning his parents Osorkon I and Maatkare. Cairo, CG 42194SpousePharaoh Osorkon IIssueShoshenq CDynasty22nd DynastyFatherPsusennes II Maatkare[1]in hieroglyphs Era: 3rd Intermediate Period(1069–664 BC) Maatkare B was a wife of pharaoh Osorkon I and the mother of the High Priest of Amun Shoshenq C. Maatkare was the daughter of Psusennes II (also known as Pasebkhanut II).[2]…
此条目或其章节有關連載中或未完結的作品。維基百科不是新聞的收集处。請留心記載正確信息,在信息相對明确之後進行編輯更新。 烙印戰士 ベルセルク Berserk 罗马字 Beruseruku 類型 黑暗奇幻、史詩 正式譯名 烙印勇士 烙印戰士 常用譯名 剑风传奇 漫画 原作 三浦建太郎(1-364話)監修:森恆二(365話-) 作畫 STUDIO 我畫(365話-) 出版社 白泉社 東立出版社 天下出版 連載…
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Laupheim Air Base – news · newspapers · books · scholar · JSTOR (February 2010) (Learn how and when to remove this template message) Air base in Germany Laupheim Air BaseMilitärflugplatz LaupheimIATA: noneICAO: ETHLSummaryAirport typeMilitaryOwnerFederal Ministry…
Marinated celery salad dish Celery VictorTypeSaladPlace of originUnited StatesRegion or stateCaliforniaCreated byVictor HirtzlerMain ingredientsCelery, stock, peppers, Romaine lettuce Celery Victor is an historical American marinated celery salad dish invented in 1910 by Victor Hirtzler, head chef at San Francisco's St. Francis Hotel,[1] who is also credited with inventing Crab Louie.[2] The dish, an American classic,[3] was popularized by author Clarence Edwords in his 1…
Bridge in Taranaki, New ZealandBertrand Road suspension bridgeCoordinates39°02′50″S 174°15′18″E / 39.0473°S 174.2550°E / -39.0473; 174.2550CarriesOne lane of Bertrand road 4 tonne limitCrossesWaitara RiverLocaleTaranaki, New ZealandCharacteristicsDesignSuspension BridgeLongest span61 metres (200 ft)HistoryConstruction end1927Location The Bertrand Road suspension bridge crosses the Waitara River, linking Huirangi, near Lepperton and Tikorangi in north Tara…
Cloth covering laid over a horse or other animal for protection and decoration This article is about the covering laid over an animal. For the guitar company, see Caparison Guitars. For the caparisoned horse in military funerals, see Riderless horse. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Caparison – news · newspapers…
Hideo IijimaHideo Iijima at the 1964 OlympicsPersonal informationBorn (1944-01-01) January 1, 1944 (age 79)Mito, Ibaraki, JapanHeight1.75 m (5 ft 9 in)Weight75 kg (165 lb)SportSportSprint running, baseball Medal record Representing Japan Asian Games 1962 Jakarta 200 m 1962 Jakarta 4×100 m 1966 Bangkok 100 m Summer Universiade 1965 Budapest 100 m Hideo Iijima (飯島 秀雄, Iijima Hideo, born January 1, 1944) is a retired Japanese sprint runner and profession…
Italian footballer Luigi Brunella Personal informationDate of birth 14 April 1914[1]Place of birth Garlasco, ItalyPosition(s) DefenderSenior career*Years Team Apps (Gls)1932–1935 Vigevanesi 1935–1939 Torino 86 (0)1939–1943 Roma 92 (0)1944 Juventus 24 (0)1945–1948 Roma 66 (1)Managerial career1948–1949 Roma *Club domestic league appearances and goals Luigi Brunella (14 April 1914 – 23 May 1993) was an Italian football defender and manager from Garlasco. He spent the largest maj…
This article is about the group of islands. For the island within Babuyan Islands, see Babuyan Island. Island group in the Philippines Babuyan IslandsBabuyan Islands of Luzon StraitBabuyan IslandsLocation within the PhilippinesGeographyLocationLuzon StraitCoordinates19°15′N 121°40′E / 19.250°N 121.667°E / 19.250; 121.667Adjacent toBabuyan ChannelBalintang ChannelTotal islands24Major islandsBabuyan IslandCalayan IslandCamiguin IslandDalupiri IslandFuga IslandArea60…
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