DNAJC14

DNAJC14

Identifiers

DNAJC14, DNAJ, DRIP78, HDJ3, LIP6, DnaJ heat shock protein family (Hsp40) member C14

External IDs

OMIM: 606092; MGI: 1921580; HomoloGene: 12553; GeneCards: DNAJC14; OMA:DNAJC14 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.2	Start	55,820,960 bp^[1]
Band	12q13.2	End	55,830,824 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D3	Start	128,639,931 bp^[2]
Band	10\|10 D3	End	128,655,315 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

mucosa of ileum

stromal cell of endometrium

granulocyte

smooth muscle tissue

monocyte

tibialis anterior muscle

appendix

rectum

prefrontal cortex

Top expressed in

lacrimal gland

primary oocyte

secondary oocyte

granulocyte

right lung lobe

external carotid artery

internal carotid artery

lip

zygote

tail of embryo

More reference expression data

n/a

Gene ontology
Molecular function	G protein-coupled receptor binding dopamine receptor binding
Cellular component	integral component of membrane endoplasmic reticulum membrane membrane extracellular exosome endoplasmic reticulum
Biological process	protein transport transport
Sources:Amigo / QuickGO

Species

Human

Mouse


85406


74330


ENSG00000135392


ENSMUSG00000025354


Q6Y2X3


Q921R4

RefSeq (mRNA)


NM_032364


NM_028873 NM_001359824 NM_001359825

RefSeq (protein)


NP_115740


NP_083149 NP_001346753 NP_001346754

Location (UCSC)

Chr 12: 55.82 – 55.83 Mb

Chr 10: 128.64 – 128.66 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.^[5]^[6]^[7]

Interactions

DNAJC14 has been shown to interact with Dopamine receptor D1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135392 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025354 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Bermak JC, Li M, Bullock C, Zhou QY (May 2001). "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein". Nat Cell Biol. 3 (5): 492–8. doi:10.1038/35074561. PMID 11331877. S2CID 40809366.
^ Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (May 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
^ "Entrez Gene: DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14".

Further reading

Bermak JC, Zhou QY (2004). "Accessory proteins in the biogenesis of G protein-coupled receptors". Mol. Interv. 1 (5): 282–7. PMID 14993367.
Leclerc PC, Auger-Messier M, Lanctot PM, et al. (2002). "A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling". Endocrinology. 143 (12): 4702–10. doi:10.1210/en.2002-220679. PMID 12446598.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen J, Huang Y, Wu H, et al. (2003). "Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain". J. Hum. Genet. 48 (5): 217–21. doi:10.1007/s10038-003-0012-8. PMID 12768437.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Posttranslational modification

Chaperones/
protein folding

Heat shock proteins/ Chaperonins	Hsp10/GroES Hsp27 Hsp47 HSP60/GroEL Hsp40/DnaJ A1 A2 A3 B1 B2 B11 B4 B6 B9 C1 C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α₁ α₂ β ER TRAP1
Other	Alpha crystallin Clusterin Survival of motor neuron SMN1 SMN2

Protein targeting

Ubiquitin
(ubiquitylation)

E1 Ubiquitin-activating enzyme
- UBA1
- UBA2
- UBA3
- UBA5
- UBA6
- UBA7
- ATG7
- NAE1
- SAE1

E2 Ubiquitin-conjugating enzyme
- A
- B
- C
- D1
- D2
- D3
- E1
- E2
- E3
- G1
- G2
- H
- I
- J1
- J2
- K
- L1
- L2
- L3
- L4
- L6
- M
- N
- O
- Q1
- Q2
- R1 (CDC34)
- R2
- S
- V1
- V2
- Z

E3 Ubiquitin ligase
- VHL
- Cullin
- CBL
- MDM2
- FANCL
- UBR1

Ubiquitin-like proteins
(UBL)

SUMO protein (SUMOylation)	E1 SUMO-activating enzyme SAE1 SAE2 E2 SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4
Other	ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein

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