黏菌素

黏菌素
臨床資料
懷孕分級
  • C
给药途径topical, oral, intravenous
ATC碼
法律規範狀態
法律規範
  • PoM (UK), not available in US
藥物動力學數據
生物利用度0%
生物半衰期5 hours
识别信息
  • N-(4-amino-1-(1-(4-amino-1-oxo-1-(3,12,23-tris(2-aminoethyl)- 20-(1-hydroxyethyl)-6,9-diisobutyl-2,5,8,11,14,19,22-heptaoxo- 1,4,7,10,13,18-hexaazacyclotricosan-15-ylamino)butan-2-ylamino)- 3-hydroxybutan-2-ylamino)-1-oxobutan-2-yl)-N,5-dimethylheptanamide
CAS号1264-72-8
PubChem CID
DrugBank
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.012.644 編輯維基數據鏈接
化学信息
化学式C52H98N16O13
摩尔质量1155,4495 g/mol

黏菌素(Colistin),又名克痢霉素多黏菌素E,是一种多黏菌素类多肽抗生素,是两种环状多肽——黏菌素A和B的混合物。可由多黏芽肥杆菌变种黏菌素(Bacillus polymyxa var. colistinus)产生。对多数革兰氏阴性菌有效,但具腎毒性神经毒性,故被视为“最后一线药物”[1]

註釋

  1. ^ Toxicity of polymyxins: a systematic review of the evidence from old and recent studies. doi:10.1186/cc3995. 

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