杆菌肽

杆菌肽
臨床資料
商品名英语Drug nomenclatureBaciim
AHFS/Drugs.comMonograph
懷孕分級
  • : D
给药途径外用藥物肌肉注射
ATC碼
法律規範狀態
法律規範
识别信息
  • (4R)-4-[(2S)-2-({2-[(1S)-1-amino-2-methylbutyl]- 4,5-dihydro-1,3-thiazol-5-yl}formamido)-4-methylpentanamido]-4-{[(1S)- 1-{[(3S,6R,9S,12R,15S,18R,21S)- 18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-3-(carbamoylmethyl)- 6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20- heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]carbamoyl}- 2-methylbutyl]carbamoyl}butanoic acid
CAS号1405-87-4  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
化学信息
化学式C66H103N17O16S
摩尔质量1422.69 g/mol
3D模型(JSmol英语JSmol
  • O=C(O)C[C@H]3NC(=O)[C@H](Cc1cncn1)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC(=O)[C@H](CCCCNC(=O)[C@H](CC(N)=O)NC3=O)NC(=O)[C@@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)C4N=C(SC4)\nC(N)C(C)CC)C(C)CC)C(C)CC
  • InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36?,37?,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1 checkY
  • Key:CLKOFPXJLQSYAH-NVOBBBONSA-N checkY

桿菌肽(bacitracin)是由枯草桿菌的變種「崔西」之地衣狀菌素有機體所產生的相關环肽之混合物,在1945年首次分離出來。這些肽藉由干擾"肽聚醣合成"及細胞壁而破壞革蘭氏陽性菌革兰氏阴性菌的微生物體。

桿菌肽,主要是用來作為外用製劑(因為內服使用時,它會引起腎損害)。

雖然使用任何抗生素會形成抗生素抗藥性,而杆菌肽局部的外用較少會產生如內服使用的腎損害。然而,如桿菌肽一般的抗生素機制已顯示出會有皮膚刺激的副作用,並且可能減慢癒合的程度。[1][2]

醫療用途

一管眼用杆菌肽软膏

杆菌肽是用于人类医学的多肽抗生素,并被“美国食品药品监督管理局(FDA)批准用于鸡和火鸡”,尽管在动物使用会导致抗生素耐药性[3]

活動及藥敏數據的頻譜

發展歷史

合成性

複合物

註釋

  1. ^ Spann, CT; Taylor, SC; Weinberg, JM. Topical antimicrobial agents in dermatology. Disease-a-month : DM. 2004, 50 (7): 407–21. PMID 15280871. doi:10.1016/j.disamonth.2004.05.011. 
  2. ^ Trookman, NS; Rizer, RL; Weber, T. Treatment of minor wounds from dermatologic procedures: A comparison of three topical wound care ointments using a laser wound model. Journal of the American Academy of Dermatology. 2011, 64 (3 Suppl): S8–15. PMID 21247665. doi:10.1016/j.jaad.2010.11.011. 
  3. ^ Antibiotic use on the farm hurts people—and doesn’t help the bottom line.页面存档备份,存于互联网档案馆Discover Magazine. Accessed on September 16, 2007.

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