卡茚西林

卡茚西林
臨床資料
商品名（英语：Drug nomenclature）Geocillin
其他名稱羧苄西林茚满
AHFS/Drugs.com国际药品名称
给药途径口服
ATC碼
法律規範狀態
法律規範
  • 处方药（℞-only）
识别信息
  • (2S,5R,6R)-6-([3-(2,3-dihydro-1H-inden-5-yloxy)-3-oxo-2-phenylpropanoyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS号35531-88-5
26605-69-6  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C26H26N2O6S
摩尔质量494.56 g·mol−1
3D模型（JSmol（英语：JSmol））
  • [Na+].O=C([O-])[C@@H]4N5C(=O)[C@@H](NC(=O)C(c1ccccc1)C(=O)Oc2cc3c(cc2)CCC3)[C@H]5SC4(C)C

卡茚西林（INN：Carindacillin），也称为羧苄西林茚满（USAN：Carbenicillin indanyl），是一种青霉素类抗生素。它是羧苄西林的前药。[1]

它以钠盐的形式口服给药。它以前由辉瑞公司在美国销售，商品名为Geocillin。辉瑞公司在2008年之后的某个时候从美国市场撤回了卡茚西林。[2]

药动学

在通过小肠吸收后不久，卡茚西林被水解成羧苄西林。羧苄西林通过干扰易感细菌（包括铜绿假单胞菌、大肠杆菌和一些变形杆菌）的最终细胞壁合成发挥作用。最常见的不良反应包括恶心、味觉不良、腹泻、呕吐、胀气和舌炎。卡茚西林被批准用于成人治疗前列腺炎和尿路感染。剂量在每天2000到4000毫克之间，分成等间隔的剂量。[3]

参考资料

  1. ^ English AR, Retsema JA, Ray VA, Lynch JE. Carbenicillin indanyl sodium, an orally active derivative of carbenicillin. Antimicrob. Agents Chemother. March 1972, 1 (3): 185–91. PMC 444190 可免费查阅. PMID 4558137. doi:10.1128/aac.1.3.185. 
  2. ^ Drugs@FDA: FDA-Approved Drugs CARBENICILLIN INDANYL SODIUM. www.accessdata.fda.gov. [2022-07-29]. （原始内容存档于2023-03-02）. 
  3. ^ Pfizer. GEOCILLIN® carbenicillin indanyl sodium tablets label (PDF). 2008 [2023-03-02]. （原始内容存档 (PDF)于2023-03-02）. 

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