氟喹酮

氟喹酮
臨床資料
商品名（英语：Drug nomenclature）Arofuto
其他名稱氨氟喹酮
阿洛喹酮
AHFS/Drugs.com国际药品名称
ATC碼
  • 未分配
法律規範狀態
法律規範
  • 美：未列入管制
识别信息
  • 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
CAS号56287-74-2  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C16H14FN3O
摩尔质量283.3
3D模型（JSmol（英语：JSmol））
  • O=C1C2=CC(N)=CC=C2N=C(CF)N1C3=CC=CC=C3C
  • InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3 checkY
  • Key:VDOSWXIDETXFET-UHFFFAOYSA-N checkY

氟喹酮（英语：Afloqualone）或叫氨氟喹酮，是一种喹唑啉酮类GABA能药物，是田边制药的一个团队在1970年代开发的甲喹酮的类似物。[1]由于其对GABAA受体的β亚型的激动剂活性，它具有镇静和肌肉松弛作用，[2]并且已经有一些临床用途，尽管它会导致光敏化作为​​副作用，可能导致皮肤问题，例如皮炎。[3]

参见

参考资料

  1. ^ US 3966731,Inoue I, Oine T, Yamada Y, Tani J, Ishida R, Ochiai T,「2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone」,发行于29 June 1976,指定于Tanabe Seiyaku Co Ltd 
  2. ^ Ochiai T, Ishida R. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Japanese Journal of Pharmacology. June 1982, 32 (3): 427–38. PMID 7109348. doi:10.1254/jjp.32.427 可免费查阅. 
  3. ^ Ishikawa T, Kamide R, Niimura M. Photoleukomelanodermatitis (Kobori) induced by afloqualone. The Journal of Dermatology. June 1994, 21 (6): 430–3. PMID 8064007. S2CID 7486566. doi:10.1111/j.1346-8138.1994.tb01768.x. 

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