Ofloksacin

Ofloksacin
Klinički podaci
Prodajno imeAkilen, Baccidal, Bactocin, Danoflox
Drugs.comMonografija
Način primeneOftalmički, oralno
Farmakokinetički podaci
Poluvreme eliminacije9 h
IzlučivanjeRenalno
Identifikatori
CAS broj82419-36-1 ДаY
ATC kodJ01MA01 (WHO), S01AE01
PubChemCID 4583
DrugBankDB01165 ДаY
ChemSpider4422 ДаY
KEGGC07321 ДаY
ChEBICHEBI:7731 ДаY
ChEMBLCHEMBL4 ДаY
Hemijski podaci
FormulaC18H20FN3O4
Molarna masa361,368
  • CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1
  • InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25) ДаY
  • Key:GSDSWSVVBLHKDQ-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja254 °C (489 °F)

Ofloksacin je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 361,368 Da.[1][2]

Osobine

Osobina Vrednost
Broj akceptora vodonika 7
Broj donora vodonika 1
Broj rotacionih veza 2
Particioni koeficijent[3] (ALogP) -1,4
Rastvorljivost[4] (logS, log(mol/L)) -1,6
Polarna površina[5] (PSA, Å2) 73,3

Reference

  1. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  2. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  3. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  4. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  5. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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