Enoksacin

Enoksacin
IUPAC ime
1-etil-6-fluoro-4-okso-7-(piperazin-1-il)-1,4-dihidro-1,8-naftiridin-3-karboksilna kiselina
Klinički podaci
Drugs.comMonografija
MedlinePlusa601013
Način primeneOralno
Identifikatori
CAS broj74011-58-8 ДаY
ATC kodJ01MA04 (WHO)
PubChemCID 3229
DrugBankDB00467 ДаY
ChemSpider3116 ДаY
UNII325OGW249P ДаY
KEGGD00310 ДаY
ChEBICHEBI:157175 ДаY
ChEMBLCHEMBL826 ДаY
Hemijski podaci
FormulaC15H17FN4O3
Molarna masa320,319 g/mol
  • Fc1c(nc2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CCNCC3
  • InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23) ДаY
  • Key:IDYZIJYBMGIQMJ-UHFFFAOYSA-N ДаY

Enoksacin (Almitil, Bactidan, Bactidron, Comprecin, Enoksetin, Enoxen, Enroxil, Enoxin, Enoxor, Flumark, Penetrex, Gyramid, Vinone) je oralni fluorohinolonski antibakterijski agens širokog spektra koji se koristi u tretmanu infekcija urinarnog trakta i gonoreja. Insomnija je česta nuspojava pri upotrebi ovog leka.[1][2]

Nedavno je pokazano da ova supstanca može da inhibira kancer.[3]

Reference

  1. ^ Rafalsky, V.; Andreeva, I.; Rjabkova, E.; Rafalsky, Vladimir V (2006). Rafalsky, Vladimir V, ур. „Quinolones for uncomplicated acute cystitis in women”. Cochrane Database Syst Rev. 3: CD003597. PMID 16856014. doi:10.1002/14651858.CD003597.pub2. 
  2. ^ Mogabgab, WJ. (1991). „Recent developments in the treatment of sexually transmitted diseases”. Am J Med. 91 (6A): 140S—144S. PMID 1767802. doi:10.1016/0002-9343(91)90327-T. 
  3. ^ Sonia Melo; Alberto Villanueva; Catia Moutinho; Veronica Davalos; Riccardo Spizzo; Cristina Ivan; Simona Rossi; Fernando Setien; Oriol Casanovas; Laia Simo-Riudalbas; Javier Carmona; Jordi Carrere; August Vidal; Alvaro Aytes; Sara Puertas; Santiago Ropero; Raghu Kalluri; Carlo M. Croce; George A. Calin; Manel Estellera (2011). „Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing”. PNAS. doi:10.1073/pnas.1014720108. 

Literatura

  • Patel, SS; Spencer, CM (1996). „Enoxacin: a reappraisal of its clinical efficacy in the treatment of genitourinary tract infections”. Drugs. 51 (1): 137—60. PMID 8741236. .

Spoljašnje veze


Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).